71523-78-9

Basic information

• Product Name: Acetamide, N,N'-[5-(4-chlorophenyl)-6-ethyl-2,4-pyrimidinediyl]bis-
• CAS NO: 71523-78-9
• Molecular Formula: C16H17ClN4O2
• Molecular Weight: 332.79
• Mol File: 71523-78-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Acetamide, N,N'-[5-(4-chlorophenyl)-6-ethyl-2,4-pyrimidinediyl]bis-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N,N'-[5-(4-chlorophenyl)-6-ethyl-2,4-pyrimidinediyl]bis-(71523-78-9)
• EPA Substance Registry System: Acetamide, N,N'-[5-(4-chlorophenyl)-6-ethyl-2,4-pyrimidinediyl]bis-(71523-78-9)

Safety Data

• Hazardous Substances Data: 71523-78-9(Hazardous Substances Data)

Upstream product

• 58-14-0 2,4-diamino-5-(4-chlorophenyl)-6-ethylpyrimidine 
• 108-24-7 acetic anhydride 
• 75-36-5 acetyl chloride 
• 74124-11-1 acetyl-pyrimethamine 
• 143947-41-5 C₂₆H₂₁ClN₄O₂ 
• 143947-40-4 N-[5-(4-Chloro-phenyl)-2-(2,2-dimethyl-propionylamino)-6-ethyl-pyrimidin-4-yl]-2,2-dimethyl-propionamide 
• 74124-13-3 tetracetyl-pyrimethamine 
• 74124-12-2 triacetyl-pyrimethamine 

Downstream Products

• 143947-41-5 C₂₆H₂₁ClN₄O₂ 
• 143947-40-4 N-[5-(4-Chloro-phenyl)-2-(2,2-dimethyl-propionylamino)-6-ethyl-pyrimidin-4-yl]-2,2-dimethyl-propionamide 
• 143947-39-1 Pentanoic acid [5-(4-chloro-phenyl)-6-ethyl-2-pentanoylamino-pyrimidin-4-yl]-amide 
• 143947-38-0 N-[2-Butyrylamino-5-(4-chloro-phenyl)-6-ethyl-pyrimidin-4-yl]-butyramide 
• 143947-37-9 N-[5-(4-Chloro-phenyl)-6-ethyl-2-propionylamino-pyrimidin-4-yl]-propionamide 
• 143947-46-0 N-[4-Amino-5-(4-chloro-phenyl)-6-ethyl-pyrimidin-2-yl]-benzamide 
• 143947-44-8 Pentanoic acid [4-amino-5-(4-chloro-phenyl)-6-ethyl-pyrimidin-2-yl]-amide 
• 143947-43-7 N-[4-Amino-5-(4-chloro-phenyl)-6-ethyl-pyrimidin-2-yl]-butyramide 
• 143947-45-9 N-[4-Amino-5-(4-chloro-phenyl)-6-ethyl-pyrimidin-2-yl]-2,2-dimethyl-propionamide 
• 143947-42-6 N-[4-Amino-5-(4-chloro-phenyl)-6-ethyl-pyrimidin-2-yl]-propionamide 
• 74124-11-1 acetyl-pyrimethamine 
• 58-14-0 2,4-diamino-5-(4-chlorophenyl)-6-ethylpyrimidine 
• 74124-12-2 triacetyl-pyrimethamine 

Relevant articles and documents

Regioselective Deacylation of 2,4-Diacylaminopyrimidine Derivatives by Lewis Acids and Crystal Structures of Two Products

Deacylation of 2,4-diacylamino derivatives of pyrimethamine and related diaminopyrimidines with tin(II) chloride or zinc chloride, in ethanol or propan-2-ol, affords 2-acyl-4-aminopyrimidines exclusively.Regioselective 4-deacylation was observed by 1H NMR spectroscopy and established by crystallographic analysis of the 2,4-dipropionylpyrimidine 11 and the corresponding 4-amino-2-propionylpyrimidine deacylation product 17.The latter exists in the solid state as an unusual base-pair dimer linked by two pairs of equivalent hydrogen bonds.