741693-83-4 Usage
Uses
Used in Pharmaceutical Industry:
4-Hydroxy Duloxetine b-D-Glucuronide is used as an active pharmaceutical ingredient for the development of antidepressant medications. Its role in the pharmaceutical industry is attributed to its origin as a metabolite of Duloxetine, which is a known SNRI antidepressant. This makes it a potential candidate for further research and development in the treatment of depression and related disorders.
Used in Research and Development:
In the field of scientific research, 4-Hydroxy Duloxetine b-D-Glucuronide serves as a valuable compound for studying the metabolism, pharmacokinetics, and pharmacodynamics of Duloxetine and its metabolites. This understanding can contribute to the optimization of drug dosages, treatment regimens, and the development of new therapeutic strategies for depression and other conditions treated with SNRIs.
Used in Quality Control and Standardization:
4-Hydroxy Duloxetine b-D-Glucuronide is utilized as a reference compound in the quality control and standardization of Duloxetine-containing pharmaceutical products. Its presence helps ensure the consistency, efficacy, and safety of these medications by providing a benchmark for comparison and analysis.
Used in Toxicology and Safety Studies:
This glucuronide derivative is also employed in toxicology and safety studies to evaluate the potential side effects and risks associated with the use of Duloxetine and its metabolites. Understanding the metabolic pathways and the formation of glucuronide conjugates like 4-Hydroxy Duloxetine b-D-Glucuronide can aid in the assessment of drug safety and the development of safer therapeutic alternatives.
Check Digit Verification of cas no
The CAS Registry Mumber 741693-83-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,4,1,6,9 and 3 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 741693-83:
(8*7)+(7*4)+(6*1)+(5*6)+(4*9)+(3*3)+(2*8)+(1*3)=184
184 % 10 = 4
So 741693-83-4 is a valid CAS Registry Number.
InChI:InChI=1/C24H27NO8S/c1-25-11-10-17(18-7-4-12-34-18)31-15-8-9-16(14-6-3-2-5-13(14)15)32-24-21(28)19(26)20(27)22(33-24)23(29)30/h2-9,12,17,19-22,24-28H,10-11H2,1H3,(H,29,30)/t17-,19?,20?,21?,22?,24?/m0/s1
741693-83-4Relevant articles and documents
Synthesis and biological activity of some known and putative duloxetine metabolites
Kuo,Gillespie,Kulanthaivel,Lantz,Ma,Nelson,Threlkeld,Wheeler,Yi,Zmijewski
, p. 3481 - 3486 (2007/10/03)
Several putative phase I duloxetine metabolites, 4-hydroxy-, 5-hydroxy-, 6-hydroxy-, 5-hydroxy-6-methoxy-, 6-hydroxy-5-methoxy-, 5,6-dihydroxy-, and 4,6-dihydroxyduloxetine were synthesized, and their phase II metabolite as glucuronide or sulfate conjugates were also synthesized. Their in vitro binding activities were compared to that of parent compound duloxetine.
