172033-73-7

Basic information

• Product Name: 4-FLUORO-1-NAPHTHALDEHYDE
• Synonyms: 4-FLUORO-NAPHTHALENE-1-CARBALDEHYDE;4-FLUORO-1-NAPHTHALDEHYDE;4-FLUORO-1-NAPHTHALENECARBOXALDEHYDE;4-Fluoronaphthalene-1-carboxaldehyde;4-Fluoro-1-phthaldehyde;4-Fluoro-1-naphthaldehyde 97%;4-fluoro-naphthalen-1-carbaldehyde
• CAS NO: 172033-73-7
• Molecular Formula: C₁₁H₇FO
• Molecular Weight: 174.17
• EINECS: 205-525-8
• Product Categories: Aromatics
• Mol File: 172033-73-7.mol
• Article Data: 10

Chemical Properties

• Melting Point: 79-81 °C
• Boiling Point: 307.9°C at 760 mmHg
• Flash Point: 198.7°C
• Appearance: /
• Density: 1.249g/cm³
• Vapor Pressure: 0.000706mmHg at 25°C
• Refractive Index: 1.649
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 4-FLUORO-1-NAPHTHALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUORO-1-NAPHTHALDEHYDE(172033-73-7)
• EPA Substance Registry System: 4-FLUORO-1-NAPHTHALDEHYDE(172033-73-7)

Safety Data

• Statements: 52/53
• Safety Statements: 61
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 172033-73-7(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

Uses

4-Fluoro-1-naphthaldehyde (cas# 172033-73-7) is a compound useful in organic synthesis.

Synthesis Reference(s)

The Journal of Organic Chemistry, 60, p. 6592, 1995 DOI: 10.1021/jo00125a055

InChI:InChI=1/C11H7FO/c12-11-6-5-8(7-13)9-3-1-2-4-10(9)11/h1-7H

Upstream product

• 341-41-3 1-bromo-4-fluoronaphthalene 
• 68-12-2 N,N-dimethyl-formamide 
• 79996-88-6 (4-fluoronaphthalen-1-yl)methanol 
• 42758-54-3 4-nitro-1-naphthaldehyde 
• 4885-02-3 Dichloromethyl methyl ether 
• 321-38-0 1-Fluoronaphthalene 

Downstream Products

• 1266729-02-5 N-((4-fluoronaphthalen-1-yl)methyl)cyclopropanamine 
• 79996-88-6 (4-fluoronaphthalen-1-yl)methanol 
• 3094-25-5 1-(chloromethyl)-4-fluoronaphthalene 
• 925442-44-0 4-(2,4-dichlorophenoxy)-1-naphthaldehyde 
• 315-53-7 4-fluoro-1-hydroxynaphthalene 
• 172033-90-8 4-(phenylthio)-1-naphthaldehyde 
• 172033-75-9 4-phenoxynaphthaldehyde 
• 741693-83-4 4-Hydroxy-Duloxetine Glucuronide 
• 1234382-07-0 N-(1-{4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-naphthalen-1-yl}-1H-[1,2,3]triazol-4-ylmethyl)-isonicotinamide 
• 1234381-37-3 1-{4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-naphthalen-1-yl}-1H-[1,2,4]triazole 
• 1234382-23-0 3-(4-azido-naphthalen-1-yl)-5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazole 
• 1234382-28-5 5-(3,5-dichloro-phenyl)-3-(4-fluoro-naphthalene-1-yl)-5-trifluoromethyl-4,5-dihydro-isoxazole 

Relevant articles and documents

Nickel-Catalyzed Amination of α-Aryl Methyl Ethers

α-Aryl amines are prevalent in pharmaceutically active compounds and natural products. Herein, we describe a Ni-catalyzed protocol for their synthesis from readily available α-aryl ethers. While α-aryl ethers have been used as electrophiles in Ni-catalyzed C-C bond formations, their use in C-heteroatom bond formation is much less prevalent. Preliminary mechanistic insight suggests that oxidative addition is facilitated by an anionic ligand and that reductive elimination is a reversible process.

RENIN INHIBITORS

Renin inhibitors, which are spirocyclic piperidine amides, of structural formula (I) and pharmaceutical compositions thereof useful in the treatment of cardiovascular diseases and renal insufficiency, wherein n, for each instance in which it occurs, is independently 0, 1, or 2; R1 is hydrogen, C1-6 -alkyl or C3-6 -cycloalkyl, wherein said C1-6 -alkyl or C3-6 -cycloalkyl group can be independently substituted with 1-3 halogens; A is (i) a five- or six-membered saturated or unsaturated heterocyclic or carbocyclic monocyclic ring or (ii) a five- or six-membered saturated or unsaturated heterocyclic or carbocyclic ring which is fused to another five- or six-membered saturated or unsaturated heterocyclic or carbocyclic ring, V is a bond or -(C=O)-, -CH(OH)-, -CH2- or =CH-; U is a bond or -CH2-, or for the case when V is =CH-, U is -CH=; X is =CH-, =CF-, =C(OR3)-, or -C=O-; and Y is =CH-, =CF-, =N-, or for the case when X is -C=O-, Y is -N(R3)-.

ISOXAZOLINES DERIVATIVES AND THEIR USE AS PESTICIDE

The invention relates to new pyrimidine compounds of formula (I) wherein the variables have the meaning as indicated in the claims; in free form and in salt form; and optionally the enantiomers and geometrical isomers thereof. The compounds of formula (I) are useful in the control of parasites, in particular ectoparasites, in and on warmblooded animals.