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744218-85-7

SAM-315 is a novel small molecule inhibitor of p300/CBP-associated factor (PCAF) and histone acetyltransferase (HAT) activity. It functions as a potent and selective inhibitor of PCAF, thereby inhibiting the acetylation of histone and non-histone proteins. It has shown promise as a potential therapeutic agent for the treatment of a variety of human diseases, including cancer, neurodegenerative diseases, and inflammatory disorders.
Used in Pharmaceutical Industry:
SAM-315 is used as a therapeutic agent for the treatment of various human diseases, including cancer, neurodegenerative diseases, and inflammatory disorders. It inhibits tumor growth and metastasis in cancer models, reduces inflammation in inflammatory disease models, and improves cognitive function in neurodegenerative disease models. Its ability to target histone acetylation and PCAF activity makes it a promising candidate for further development as a therapeutic agent.

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  • 744218-85-7 Structure

  • Basic information

    1. Product Name: SAM-315
    2. Synonyms: SAM-315;WAY-255315;3-naphthalen-1-ylsulfonyl-5-piperazin-1-yl-2H-indazole
    3. CAS NO:744218-85-7
    4. Molecular Formula: C21H20N4O2S
    5. Molecular Weight: 392.4741
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 744218-85-7.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: SAM-315(CAS DataBase Reference)
    10. NIST Chemistry Reference: SAM-315(744218-85-7)
    11. EPA Substance Registry System: SAM-315(744218-85-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 744218-85-7(Hazardous Substances Data)

744218-85-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 744218-85-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,4,4,2,1 and 8 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 744218-85:
(8*7)+(7*4)+(6*4)+(5*2)+(4*1)+(3*8)+(2*8)+(1*5)=167
167 % 10 = 7
So 744218-85-7 is a valid CAS Registry Number.

744218-85-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-(1-Naphthylsulfonyl)-5-(1-piperazinyl)-2H-indazole

1.2 Other means of identification

Product number -
Other names Desisopropydeoxypropranolol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:744218-85-7 SDS

744218-85-7Downstream Products

744218-85-7Relevant articles and documents

5-piperazinyl-3-sulfonylindazoles as potent and selective 5-hydroxytryptamine-6 antagonists

Liu, Kevin G.,Robichaud, Albert J.,Bernotas, Ronald C.,Yan, Yinfa,Lo, Jennifer R.,Zhang, Mei-Yi,Hughes, Zoe A.,Huselton, Christine,Zhang, Guo Ming,Zhang, Jean Y.,Kowal, Dianne M.,Smith, Deborah L.,Schechter, Lee E.,Comery, Thomas A.

experimental part, p. 7639 - 7646 (2011/02/21)

As part of our efforts to develop agents for CNS diseases, we have been focused on the 5-HT6 receptor in order to identify potent and selective ligands for cognitive enhancement. Herein we report the identification of a novel series of 5-piperazinyl-3-sulfonylindazoles as potent and selective 5-HT6 antagonists. The synthesis, SAR, and pharmacokinetic and pharmacological activities of some of the compounds including 3-(naphthalen-1-ylsulfonyl)-5-(piperazin-1-yl)-1H-indazole (WAY-255315 or SAM-315) will be described.

1-SUBSTITUTED-3-(NAPHTHALEN-1-YLSULFONYL)-5-(PIPERAZIN-1-YL)-1H-INDAZOLE COMPOUNDS AS 5-HYDROXYTRYPTAMINE-6 LIGANDS

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Page/Page column 13, (2009/12/28)

The disclosure is directed to compounds of Formula I: processes for their preparation, treatment of central nervous system (CNS) disorders and methods for the modulation of 5HT6 activity.

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