7446-34-6 Usage
Uses
Used in Pharmaceutical Industry:
Selenium sulfide is used as an active ingredient in anti-dandruff shampoos for the treatment of dandruff, seborrheic dermatitis, and tinea capitis, a fungal infection that is primarily a disease of preadolescent children. It is highly active in inhibiting the growth of P. ovale and is a proven cytostatic agent, slowing the growth of both hyperproliferative and normal cells in dandruff and seborrheic dermatitis.
Used in Agriculture Industry:
Selenium sulfide is used as a constituent of fungicides to control fungal growth in crops.
Used in Cosmetics Industry:
Selenium sulfide (SeS2) is used for some medicines, as an additive for medicated shampoos to control dandruff and scalp itching, and in treatment products for acne and eczema.
Used in Dermatology:
Selenium sulfide is used for the treatment of tinea versicolor, tinea capitis, dandruff, and seborrheic dermatitis of the scalp. A 0.6% micronized form of Selenium sulfide is also safe and effective for dandruff.
Note: Selenium sulfide is not present in foods and is a very different chemical from the organic and inorganic selenium compounds found in foods and in the environment.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
Ignition takes place when Selenium sulfide is ground with silver oxide. . Inorganic sulfides, such as Selenium sulfide, are generally basic and therefore incompatible with acids. Many of these compounds are reducing agents and therefore react vigorously with oxidizing agents, including inorganic oxoacids, organic peroxides and epoxides. Simple salts of sulfides (such as sodium, potassium, and ammonium sulfide) react vigorously with acids to release hydrogen sulfide gas.
Hazard
Toxic by ingestion, strong irritant to eyes
and skin. Questionable carcinogen.
Fire Hazard
Flash point data for Selenium sulfide are not available; however, Selenium sulfide is probably combustible.
Clinical Use
Selenium sulfide is a cytostatic and sporicidal agent
available without prescription in a variety of shampoos
and lotions for treatment of scalp seborrheic dermatitis.
Safety Profile
Confirmed carcinogen with experimental carcinogenic data. Poison by ingestion. Mutation data reported. When heated to decomposition it emits very toxic fumes of SO, and Se. See also SELENIUM COMPOUNDS and SULFIDES.
Potential Exposure
Selenium sulfide is used for the treatment of seborrhea, especially in shampoos. The chemical is available over the counter as Selsun, a stabilized buffered suspension. FDA reports that selenium sulfide is an active ingredient in some drug products used for the treatment of dandruff and certain types of dermatitis. A dandruff shampoo containing 1% selenium sulfide is available without a prescription and is recommended for use once or twice a week. By prescription, selenium sulfide is available in a 2.5% shampoo or lotion, with the recommended application limited to 10 minutes for 7 days to avoid the possibility of acute toxic effects. Selenium sulfide is also used topically in veterinary medicine for eczemas and dermatomycoses.
Veterinary Drugs and Treatments
Selenium sulfide may be useful in seborrheic disorders (mainly for seborrhea oleosa) and for adjunctive treatment of Malassezia dermatitis,
particularly in dogs exhibiting signs of waxy, greasy or scaly (seborrheic) dermatitis. There may be some residual activity on the skin.
Selenium sulfide possesses antifungal (including sporicidal activity), keratolytic, keratoplastic and degreasing properties. It affects
cells of the epidermis and follicular epithelium (alters the epidermal turnover) and interferes with hydrogen bond formation of keratin
thereby reducing corneocyte production. Selenium sulfide’s antifungal mechanism of action is not well understood.
Carcinogenicity
Selenium sulfide is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
Shipping
UN2657 Selenium disulfide, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
Incompatibilities
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Violent reaction with silver oxide.
Check Digit Verification of cas no
The CAS Registry Mumber 7446-34-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,4,4 and 6 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 7446-34:
(6*7)+(5*4)+(4*4)+(3*6)+(2*3)+(1*4)=106
106 % 10 = 6
So 7446-34-6 is a valid CAS Registry Number.
InChI:InChI=1/H2SSe2/c2-1-3/h2-3H
7446-34-6Relevant articles and documents
METHOD AND PREPARATION FOR TREATING BALDNESS
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, (2010/08/22)
Various embodiments of the present invention are directed to hair-loss, and include treatments and preparations. Embodiments of the present invention include bactericides, combinations of bactericides and fungicides, combination of bactericides and vasodilators, and combinations of bactericides, fungicides, and vasodilators that are delivered topically to pilosebaceous units within the scalps of persons suffering from hair loss. The treatment kills or controls microbes that disrupt hair growth by changing, inhibiting, or interrupting one or more biological functions of the pilosebaceous units. Certain embodiments of the present invention contain additional active and inactive ingredients, including anti-inflammatory agents, carriers, emulsifiers, antioxidants, and other such substances.
