- METHOD OF MAKING AZAINDAZOLE DERIVATIVES
-
Disclosed are methods, reagents, and intermediates useful for making azaindazole derivatives, which may be used to modulate Glucokinase. The disclosed methods and materials are generally useful for making halo-esters and sulfonyl-substituted compounds.
- -
-
Page/Page column 28
(2012/05/04)
-
- PROCESS FOR THE PRODUCTION OF 2-AMINO-5-FLUOROTHIAZOLE
-
A process for the production of fluorinated compound represented by the formula (I): or salts thereof wherein R1 and R2 are the same or different and each is selected from the group consisting of a hydrogen atom, a carbonyl group, a
- -
-
Page/Page column 13-14
(2011/10/10)
-
- HYDRAZONE DERIVATIVE
-
A hydrazone derivative of formula [I]: wherein Ring A is aryl or heteroaryl, Ring T is heteroaryl or heterocycle, R1 and R2 are independently hydrogen atom, halogen atom, cycloalkylsulfonyl, etc., R3 and R4 comb
- -
-
Page/Page column 54-55
(2009/10/06)
-
- Practical synthesis of 2-amino-5-fluorothiazole hydrochloride
-
The first synthesis of 2-amino-5-fluorothiazole hydrochloride is reported from 2-aminothiazole. The synthesis proceeds in 35% overall yield, involves no chromatographic purification, and has been employed to prepare multikilogram quantities of the title c
- Briner, Paul H.,Fyfe, Matthew C. T.,Martin, Pierre,Murray, P. John,Naud, Frederic,Procter, Martin J.
-
supporting information
p. 346 - 348
(2012/12/22)
-
- FLUORINATION PROCESS OF PROTECTED AMINOTHIAZOLE
-
A process for the production of fluorinated compound formula (I) comprising fluorination of a protected aminothiazole. Compounds formula (I) are useful in the preparation of activators of glucokinase.
- -
-
Page/Page column 21
(2010/10/20)
-
- ENANTIOSELECTIVE PROCESS
-
A process for the production of compounds comprising the enantioselective hydrogenation of 2-substituted acrylic acid derivatives.
- -
-
Page/Page column 9
(2008/06/13)
-
- TRI(CYCLO) SUBSTITUTED AMIDE COMPOUNDS
-
Compounds of Formula (I) or pharmaceutically acceptable salts thereof, are useful in the prophylactic and therapeutic treatment of hyperglycemia and diabetes.
- -
-
Page/Page column 16-17
(2010/02/14)
-
- TRI(CYCLO) SUBSTITUTED AMIDE COMPOUNDS
-
Compounds of Formula (I): or pharmaceutically acceptable salts thereof, are useful in the prophylactic and therapeutic treatment of hyperglycemia and diabetes.
- -
-
-
- TRI(CYCLO) SUBSTITUTED AMIDE GLUCOKINASE ACTIVATOR COMPOUNDS
-
Compounds of Formula (I): (I) or pharmaceutically acceptable salts or N-oxides thereof, are useful in the prophylactic and therapeutic treatment of hyperglycemia and diabetes.
- -
-
-