745053-64-9

Usage

Uses

5-Fluorothiazol-2-amine Hydrochloride can be used as anti-tumor agents.

InChI:InChI=1/C3H3FN2S.ClH/c4-2-1-6-3(5)7-2;/h1H,(H2,5,6);1H

Upstream product

• 731018-54-5 2-(tert-butoxycarbonyl)amino-5-fluorothiazole 
• 876379-99-6 2-acetamido-5-fluorothiazole 
• 40283-46-3 2-aminothiazole-5-carboxylic acid 
• 745053-67-2 N-(5-fluorothiazol-2-yl)-2,2,2-trifluoroacetamide 

Downstream Products

• 64588-82-5 5-fluoro-1,3-thiazol-2-amine 
• 745051-61-0 PSN-GK1 
• 1325706-40-8 3-(6-cyclopropanesulfonylpyridin-3-yloxy)-N-(5-fluorothiazol-2-yI)-5-isopropoxybenzamide 
• 1454666-63-7 N-(5-fluorothiazol-2-yl)-5-(2-(5-methyl-1H-imidazol-1-yl)-4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide 
• 1454666-62-6 N-(5-fluorothiazol-2-yl)-5-(2-(4-methyl-1H-imidazol-1-yl)-4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide 
• 1454666-61-5 N-(5-fluorothiazol-2-yl)-5-(2-(4-methylpiperazin-1-yl)-4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide 
• 1204244-03-0 (4-fluorophenyl)(4-(5-fluorothiazol-2-ylamino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)methanone 
• 1039016-49-3 C₁₈H₁₉FN₄O₄S₂ 
• 1282521-02-1 3-acetoxymethyl-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(5-fluorothiazol-2-yl)-benzamide 

Relevant academic research and scientific papers

METHOD OF MAKING AZAINDAZOLE DERIVATIVES

Disclosed are methods, reagents, and intermediates useful for making azaindazole derivatives, which may be used to modulate Glucokinase. The disclosed methods and materials are generally useful for making halo-esters and sulfonyl-substituted compounds.

PROCESS FOR THE PRODUCTION OF 2-AMINO-5-FLUOROTHIAZOLE

A process for the production of fluorinated compound represented by the formula (I): or salts thereof wherein R1 and R2 are the same or different and each is selected from the group consisting of a hydrogen atom, a carbonyl group, a

HYDRAZONE DERIVATIVE

A hydrazone derivative of formula [I]: wherein Ring A is aryl or heteroaryl, Ring T is heteroaryl or heterocycle, R1 and R2 are independently hydrogen atom, halogen atom, cycloalkylsulfonyl, etc., R3 and R4 comb

Practical synthesis of 2-amino-5-fluorothiazole hydrochloride

The first synthesis of 2-amino-5-fluorothiazole hydrochloride is reported from 2-aminothiazole. The synthesis proceeds in 35% overall yield, involves no chromatographic purification, and has been employed to prepare multikilogram quantities of the title c

FLUORINATION PROCESS OF PROTECTED AMINOTHIAZOLE

A process for the production of fluorinated compound formula (I) comprising fluorination of a protected aminothiazole. Compounds formula (I) are useful in the preparation of activators of glucokinase.

ENANTIOSELECTIVE PROCESS

A process for the production of compounds comprising the enantioselective hydrogenation of 2-substituted acrylic acid derivatives.

TRI(CYCLO) SUBSTITUTED AMIDE COMPOUNDS

Compounds of Formula (I) or pharmaceutically acceptable salts thereof, are useful in the prophylactic and therapeutic treatment of hyperglycemia and diabetes.

TRI(CYCLO) SUBSTITUTED AMIDE COMPOUNDS

Compounds of Formula (I): or pharmaceutically acceptable salts thereof, are useful in the prophylactic and therapeutic treatment of hyperglycemia and diabetes.

TRI(CYCLO) SUBSTITUTED AMIDE GLUCOKINASE ACTIVATOR COMPOUNDS

Compounds of Formula (I): (I) or pharmaceutically acceptable salts or N-oxides thereof, are useful in the prophylactic and therapeutic treatment of hyperglycemia and diabetes.