745812-13-9

Basic information

• Product Name: 2-Propenenitrile,2-fluoro-3-(2-pyridinyl)-(9CI)
• Synonyms: 2-Propenenitrile,2-fluoro-3-(2-pyridinyl)-(9CI)
• CAS NO: 745812-13-9
• Molecular Formula: C8H5FN2
• Molecular Weight: 148.1371032
• Product Categories: PYRIDINE
• Mol File: 745812-13-9.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Propenenitrile,2-fluoro-3-(2-pyridinyl)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenenitrile,2-fluoro-3-(2-pyridinyl)-(9CI)(745812-13-9)
• EPA Substance Registry System: 2-Propenenitrile,2-fluoro-3-(2-pyridinyl)-(9CI)(745812-13-9)

Safety Data

• Hazardous Substances Data: 745812-13-9(Hazardous Substances Data)

Usage

Classification

nitrile compound

Uses

pharmaceutical and agrochemical industries, as a building block for synthesis of organic compounds, intermediate in production of other chemicals, valuable reagent in organic synthesis

Potential applications

medicinal chemistry for pharmaceutical drug development

Properties

toxic and potentially hazardous, handle with care

Upstream product

• 1121-60-4 pyridine-2-carbaldehyde 
• 2537-48-6 diethyl 1-cyanomethylphosphonate 
• 745812-08-2 (diphenylphosphinoyl)fluoroacetonitrile 

Relevant articles and documents

α-Fluoroacrylonitriles: Horner-Wittig synthesis and conversion into 2-fluoroallylamines and C-(1-fluorovinyl)nitrones

α-Fluoroacrylonitriles 2 were synthesized in moderate to good yields by Horner-Wittig (HW) reaction of aldehydes and ketones with (diphenylphosphinoyl)fluoroacetonitrile (1), prepared in situ from commercially available fluoroacetonitrile and diphenylphosphinyl chloride. New synthetic applications of 2 are presented with the one-pot conversion into 2-fluoroallylamines 6 and C-(1-fluorovinyl)nitrones 8 through a diisobutylaluminum hydride (DIBALH)-reduction transimination protocol. The scope and limitations of this procedure are discussed.

A Convenient One-pot Synthesis of α-Fluoro-α,β-unsaturated Nitriles From Diethyl Cyanofluoromethanephosphonate

The carbanion of diethyl 1-cyano-1-fluoromethanephosphonate 3, generated in situ from diethyl cyanomethanephosphonate 2 and N-fluorobis(trifluoromethanesulfonyl)imide 1, undergoes the Wittig-Horner reaction with aldehydes and ketones to yield α-fluoro-α,β-unsaturated nitriles 5.