74650-71-8

Basic information

• Product Name: 2-chloro-5-Methoxy-3-pyridinecarboxylic acid
• Synonyms: 2-chloro-5-Methoxy-3-pyridinecarboxylic acid;2-chloro-5-methoxypyridine-3-carboxylic acid
• CAS NO: 74650-71-8
• Molecular Formula: C₇H₆ClNO₃
• Molecular Weight: 187.58044
• Mol File: 74650-71-8.mol

Chemical Properties

• Boiling Point: 354.5±37.0 °C(Predicted)
• Appearance: /
• Density: 1.430±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 1.90±0.25(Predicted)
• CAS DataBase Reference: 2-chloro-5-Methoxy-3-pyridinecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-5-Methoxy-3-pyridinecarboxylic acid(74650-71-8)
• EPA Substance Registry System: 2-chloro-5-Methoxy-3-pyridinecarboxylic acid(74650-71-8)

Safety Data

• Hazardous Substances Data: 74650-71-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-chloro-5-methoxy-3-pyridinecarboxylic acid is used as a building block for the synthesis of pharmaceuticals due to its potential antifungal and anticancer properties. Its presence in the development of new drugs can contribute to the treatment of various diseases and conditions.
Used in Agrochemical Industry:
2-chloro-5-methoxy-3-pyridinecarboxylic acid is used as a building block in the synthesis of agrochemicals, where it can contribute to the development of new pesticides or other agricultural chemicals to improve crop protection and yield.
Used as an Intermediate in Organic Compounds Production:
2-chloro-5-methoxy-3-pyridinecarboxylic acid is used as an intermediate in the production of various organic compounds. Its unique structure with both a chloro and methoxy group allows it to participate in a wide range of chemical reactions, making it a valuable component in the synthesis of diverse organic molecules.

Upstream product

• 1256791-15-7 methyl 2-chloro-5-methoxynicotinate 
• 42959-40-0 2-Chlor-5-hydroxy-nicotinsaeure 
• 7732-18-5 water 
• 74650-70-7 2-chloro-5-methoxy-3-methylpyridine 
• 54232-03-0 2-chloro-5-hydroxy-3-methylpyridine 
• 38186-82-2 6-chloro-5-methylpyridin-3-amine 

Downstream Products

• 1256791-15-7 methyl 2-chloro-5-methoxynicotinate 
• 74650-77-4 (S)-5-benzyloxy-2-(3-t-butylamino-2-hydroxypropoxy)nicotinonitrile 
• 74650-76-3 5-benzyloxy-2-chloronicotinonitrile 
• 74650-73-0 2-chloro-3-cyano-5-methoxypyridine 

Relevant articles and documents

Pharmacological Evaluation of Novel Bioisosteres of an Adamantanyl Benzamide P2X7 Receptor Antagonist

Adamantanyl benzamide 1 was identified as a potent P2X7R antagonist but failed to progress further due to poor metabolic stability. We describe the synthesis and SAR of a series of bioisosteres of benzamide 1 to explore improvements in the pharmacological properties of this lead. Initial efforts investigated a series of heteroaromatic bioisosteres, which demonstrated improved physicochemical properties but reduced P2X7R antagonism. Installation of bioisosteric fluorine on the adamantane bridgeheads was well tolerated and led to a series of bioisosteres with improved physicochemical properties and metabolic stability. Trifluorinated benzamide 34 demonstrated optimal physicochemical parameters, superior metabolic stability (ten times longer than lead benzamide 1), and an improved physicokinetic profile and proved effective in the presence of several known P2X7R polymorphisms.

2-SUBSTITUTED PROPOXY-3-CYANO-5-HYDROXYPYRIDINES AND USE AS ANTIHYPERTENSIVES

The present application discloses certain 2-substituted propoxy-3-cyano-5-hydroxypyridines. The compounds have pharmaceutical activity e.g. as antihypertensives.

2-Substituted propoxy-3-cyano-5-RO-pyridines and intermediates

The present application discloses 2-substituted propoxy-3-cyano-5-RO-pyridines and intermediates therefor. The former compounds have pharmaceutical activity.

Synthesis of 2-Chloro-5-hydroxynicotinonitrile: The Required Intermediate in the Total Synthesis of a Hydroxylated Metabolite of (S)-2-(3-t-Butylamino-2-hydroxypropoxy)-3-cyanopyridine

A convenient method for the synthesis of 2-chloro-5-hydroxynicotinonitrile (10) via 5-amino-2-chloro-3-methylpyridine (3) is described.Subsequent conversions provided the basic metabolite 2 of (S)-2-(3-t-butylamino-2-hydroxypropoxy)-3-cyanopyridine (1). 1