38186-82-2

Basic information

• Product Name: 5-AMINO-2-CHLORO-3-PICOLINE
• Synonyms: 6-CHLORO-5-METHYLPYRIDIN-3-AMINE;6-CHLORO-5-METHYL-PYRIDIN-3-YLAMINE;5-AMINO-2-CHLORO-3-PICOLINE;2-chloro-3-methyl-5-aminopyridine;5-AMINO-2-CHLORO-3-METHYLPYRIDINE;2-CHLORO-5-AMINO-3-PICOLINE;5-Amino-2-chloro-3-picoline ,97%;3-amine-6-chloro-5-methylpyridine
• CAS NO: 38186-82-2
• Molecular Formula: C₆H₇ClN₂
• Molecular Weight: 142.59
• Product Categories: Pyridine;pharmacetical;Pyridine series;Amines;Pyridines
• Mol File: 38186-82-2.mol
• Article Data: 15

Chemical Properties

• Melting Point: 90.0 to 94.0 °C
• Boiling Point: 304.689 °C at 760 mmHg
• Flash Point: 138.071 °C
• Appearance: /
• Density: 1.26 g/cm³
• Refractive Index: 1.596
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 2.06±0.10(Predicted)
• CAS DataBase Reference: 5-AMINO-2-CHLORO-3-PICOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINO-2-CHLORO-3-PICOLINE(38186-82-2)
• EPA Substance Registry System: 5-AMINO-2-CHLORO-3-PICOLINE(38186-82-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41-36/37/38-20/21/22
• Safety Statements: 26-39-36/37/39
• RIDADR: 2811
• WGK Germany: 3
• Hazardous Substances Data: 38186-82-2(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow solid

InChI:InChI=1/C6H7ClN2/c7-3-6-2-1-5(8)4-9-6/h1-2,4H,3,8H2

Upstream product

• 22280-56-4 2-chloro-3-methyl-5-nitropyridine 
• 144-55-8 sodium hydrogencarbonate 
• 7732-18-5 water 
• 7439-89-6 iron 

Downstream Products

• 29241-60-9 5-bromo-2-chloro-3-methylpyridine 
• 59782-88-6 2,5-Dichloro-3-methylpyridine 
• 54232-04-1 6-chloro-5-methylpyridine-3-yl acetate 
• 228867-86-5 5-hydroxy-3-methylpyridine-2-carbonitrile 
• 1624607-04-0 5-((4-methoxybenzyl)oxy)-3-methyl-2-vinylpyridine 
• 1624607-03-9 2-chloro-5-((4-methoxybenzyl)oxy)-3-methylpyridine 
• 54232-03-0 2-chloro-5-hydroxy-3-methylpyridine 
• 37105-10-5 6-chloro-5-methyl-3-pyridinesulfonyl chloride 
• 59782-89-7 2-Chloro-5-iodo-3-methylpyridine 
• 74650-77-4 (S)-5-benzyloxy-2-(3-t-butylamino-2-hydroxypropoxy)nicotinonitrile 
• 74650-76-3 5-benzyloxy-2-chloronicotinonitrile 
• 74650-80-9 5-benzyloxy-2-chloro-3-methylpyridine 
• 74650-71-8 2-chloro-5-methoxy-3-pyridinecarboxylic acid 
• 74650-73-0 2-chloro-3-cyano-5-methoxypyridine 

Relevant articles and documents

CYCLOPROPYL FUSED THIAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE

The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula (I): wherein variables A4, A5, A6, A8, and each of Ra, Rb, R1, R2, R3 and R7 of Formula (I), independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and 15 deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimers Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas (II) and (III), and sub-formula embodiments thereof, intermediates and methods for preparing compounds of the invention.

Proton pump inhibitors

A proton pump inhibitor containing a compound represented by the formula (I) wherein X and Y are the same or different and each is a bond or a spacer having 1 to 20 carbon atoms in the main chain, R 1 is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, R 2 , R 3 and R 4 are the same or different and each is a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted thienyl group, an optionally substituted benzo[b]thienyl group, an optionally substituted furyl group, an optionally substituted pyridyl group, an optionally substituted pyrazolyl group, an optionally substituted pyrimidinyl group, an acyl group, a halogen atom, a cyano group or a nitro group, R 5 and R 6 are the same or different and each is a hydrogen atom or an optionally substituted hydrocarbon group, which has a superior proton pump action and shows an antiulcer activity and the like after conversion to a proton pump inhibitor in the body, or a salt thereof. or a prodrug thereof is provided.

PERFLUORINATED 5,6-DIHYDRO-4H-1,3-OXAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE

The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A4, A5, A6, A8, each of R1 and R2, R3 and R7 of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas II and III, and sub-formula embodiments thereof, intermediates and processes and methods useful for the preparation of compounds of Formulas I-III.