Ophiopogon Root (root of Ophiopogon japonicus Ker-Gawler, Liliaceae) is a crude drug used as expectorant, anti-cough and tonic in Kampo medicine (traditional Japanese medicine) as well as other traditional medicines of Asian countries. It contains characteristic homoisoflavonoids with methylated ring A. We synthesized methylophiopogonanone A (1), which is a candidate marker compound for identification test of Ophiopogon Root, from phloroglucinol in 9 steps with overall yield of 11.1%.
Studies on the Constituents of Ophiopogonis Tuber. V. Isolation of a Novel Class of Homoisoflavonoids and Determination of Their Structures (1)
New homoisoflavonoidal compounds, methylophiopogonanone A (Ia), methylophiopogonanone B (IIa), methylophiopogonone A (IIIa) and methylophiopogonone B (IVa), were isolated from ophiopogonis tubers (tubers of Ophiopogon japonicus KER-GAWLER var. genuinus MA
Tada, Akihiro,Kasai, Ryoji,Saitoh, Tamotsu,Shoji, Junzo
p. 1477 - 1484
(2007/10/02)
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