- A one-pot pseudo nine-component isocyanide-based reaction: Synthesis of a new class of zinc 1,5-disubstituted 1H-tetrazol-5-yl coordination complexes
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A novel one-pot pseudo nine-component synthesis of zinc 1,5-disubstituted 1H-tetrazol-5-yl coordination complexes in good yields starting from simple and readily available substrates, including a 1,3-dicarbonyl compound, an isocyanide, N,N-dimethylformami
- Shaabani, Ahmad,Mahyari, Mojtaba,Seyyedhamzeh, Mozhdeh,Keshipour, Sajjad,Ng, Seik Weng
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Read Online
- Tetrahydroquinazole-based secondary sulphonamides as carbonic anhydrase inhibitors: synthesis, biological evaluation against isoforms I, II, IV, and IX, and computational studies
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A library of variously decorated N-phenyl secondary sulphonamides featuring the bicyclic tetrahydroquinazole scaffold was synthesised and biologically evaluated for their inhibitory activity against human carbonic anhydrase (hCA) I, II, IV, and IX. Of not
- Baglini, Emma,Barresi, Elisabetta,Berrino, Emanuela,Castellano, Sabrina,Cosconati, Sandro,Da Settimo, Federico,Marini, Anna Maria,Ravichandran, Rahul,Salerno, Silvia,Supuran, Claudiu T.,Taliani, Sabrina,Viviano, Monica
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Read Online
- Inhibition studies on carbonic anhydrase isoforms I, II, IV and IX with N-arylsubstituted secondary sulfonamides featuring a bicyclic tetrahydroindazole scaffold
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Carbonic Anhydrases (CAs) are pharmaceutically relevant targets for the treatment of several disease conditions. The ubiquitous localization of these enzymes and the high homology shared by the different isoforms represent substantial impediments for the
- Salerno, Silvia,Amendola, Giorgio,Angeli, Andrea,Baglini, Emma,Barresi, Elisabetta,Marini, Anna Maria,Ravichandran, Rahul,Viviano, Monica,Castellano, Sabrina,Novellino, Ettore,Da Settimo, Federico,Supuran, Claudiu T.,Cosconati, Sandro,Taliani, Sabrina
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Read Online
- Ultrasound assisted regioselective synthesis, photophysical and structural studies of 1-substituted indazol-4(5H)-ones and enaminodiketones of dimedone
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Enaminodiketone, obtained from reaction of dimedone with DMF-DMA, on reaction with nucleophiles such as amines, guanidine hydrochloride and substituted aromatic hydrazines furnished enaminodiketones, quinazolines and indazole derivatives respectively. The
- Chaudhary, R. P.,Gautam, Deepika,Gautam, Poonam,Mittal, Isha
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- Discovery and Optimization of 2 H-1λ2-Pyridin-2-one Inhibitors of Mutant Isocitrate Dehydrogenase 1 for the Treatment of Cancer
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Neomorphic mutations in isocitrate dehydrogenase 1 (IDH1) are oncogenic for a number of malignancies, primarily low-grade gliomas and acute myeloid leukemia. We report a medicinal chemistry campaign around a 7,7-dimethyl-7,8-dihydro-2H-1λ2-quinoline-2,5(6H)-dione screening hit against the R132H and R132C mutant forms of isocitrate dehydrogenase (IDH1). Systematic SAR efforts produced a series of potent pyrid-2-one mIDH1 inhibitors, including the atropisomer (+)-119 (NCATS-SM5637, NSC 791985). In an engineered mIDH1-U87-xenograft mouse model, after a single oral dose of 30 mg/kg, 16 h post dose, between 16 and 48 h, (+)-119 showed higher tumoral concentrations that corresponded to lower 2-HG concentrations, when compared with the approved drug AG-120 (ivosidenib).
- Rohde, Jason M.,Karavadhi, Surendra,Pragani, Rajan,Liu, Li,Fang, Yuhong,Zhang, Weihe,McIver, Andrew,Zheng, Hongchao,Liu, Qingyang,Davis, Mindy I.,Urban, Daniel J.,Lee, Tobie D.,Cheff, Dorian M.,Hollingshead, Melinda,Henderson, Mark J.,Martinez, Natalia J.,Brimacombe, Kyle R.,Yasgar, Adam,Zhao, Wei,Klumpp-Thomas, Carleen,Michael, Sam,Covey, Joseph,Moore, William J.,Stott, Gordon M.,Li, Zhuyin,Simeonov, Anton,Jadhav, Ajit,Frye, Stephen,Hall, Matthew D.,Shen, Min,Wang, Xiaodong,Patnaik, Samarjit,Boxer, Matthew B.
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p. 4913 - 4946
(2021/05/07)
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- SHP2 INHIBITORS, COMPOSITIONS AND USES THEREOF
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Provided are compounds of Formula (I), methods of using the compounds as SHP2 inhibitors, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating SHP2-mediated diseases.
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Page/Page column 110-111
(2021/12/30)
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- 4-Substituted Benzenesulfonamides Incorporating Bi/Tricyclic Moieties Act as Potent and Isoform-Selective Carbonic Anhydrase II/IX Inhibitors
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As a part of our efforts to expand chemical diversity in the carbonic anhydrases inhibitors (CAIs), three small series of polyheterocyclic compounds (4-6) featuring the primary benzenesulfonamide moiety linked to bi/tricyclic scaffolds were investigated. Highly effective inhibitors against the target tumor-associated hCA IX (low nanomolar/subnanomolar potency levels) showing significant functional selectivity profile toward hCA I, II, and IV isozymes were identified. Molecular docking studies clarified the reasons behind the activity and selectivity of the new compounds.
- Salerno, Silvia,Barresi, Elisabetta,Amendola, Giorgio,Berrino, Emanuela,Milite, Ciro,Marini, Anna Maria,Da Settimo, Federico,Novellino, Ettore,Supuran, Claudiu T.,Cosconati, Sandro,Taliani, Sabrina
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p. 5765 - 5770
(2018/06/27)
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- Synthesis of some novel pyrazolo[1,5-a]quinazolines and their fused derivatives
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New pyrazolo[1,5-a]quinazoline-3-carbonitriles 4a,b were obtained via cyclocondensation of 5-amino-3-cyanomethyl-1H-pyrazole-4-carbonitrile (1) with enaminones of 1,3-cyclohexanedione derivatives 2a,b in refluxing glacial acetic acid. Condensation of compounds 4a,b with various aromatic aldehydes furnished the corresponding arylidene derivatives 6a–j. On the other hand, condensation of 4a,b with o-hydroxybenzaldehydes yielded the polyheterocyclic compounds 10a–h. Coupling of compounds 4a,b with aryldiazonium chlorides led to formation of 2-arylhydrazono derivatives 12a–h. Also, reaction of compounds 4a,b with phenyl isothiocyanate, followed by addition of ethyl chloroacetate and chloroacetonitrile, afforded the polyheterocyclic compounds based on pyrazolo[1,5-a]quinazoline core. The reaction of compounds 4a,b with phenyl isothiocyanate and elemental sulfur gave the thiazole-2-thione derivatives 25a,b. The reaction of enamines of compounds 4a,b with each of hydrazine hydrate and guanidine hydrochloride afforded pyrazolo[4″,3″:5′,6′]pyrido[4′,3′:3,4]pyrazolo[1,5-a]quinazolin-8-ones 30a,b and pyrimido[5″,4″:5′,6′]pyrido[4′,3′:3,4]pyrazolo[1,5-a]quinazolin-9(10H)-ones 33a,b, respectively. The structures of all the newly synthesized compounds were elucidated by elemental analyses and spectral data. The plausible mechanisms have been postulated to account for their formation.
- Ragab, Eman Ali,Metwally, Nadia Hanafy,Mohamed, Mona Said
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supporting information
p. 148 - 158
(2017/01/10)
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- One-pot Synthesis of Benzo[4,5]imidazo[1,2-a]pyridine Derivatives in Aqueous Conditions
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One-pot reaction of cyclic 1,3-diketones, dimethylformamide dimethylacetal (DMFDMA) and 2-(1H-benzo[d]imidaz-2-yl)acetonitrile was found to be a highly selective process leading to 4-oxo-1,2,3,4-tetrahydrobenzo[4,5]imidazo[1,2-a]quinolin-6-yl cyanides. Op
- Vodolazhenko, Maria A.,Mykhailenko, Anastasiia E.,Gorobets, Nikolay Yu.,Desenko, Sergey M.
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p. 753 - 757
(2017/02/03)
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- Multicomponent Dipolar Cycloaddition Strategy: Combinatorial Synthesis of Novel Spiro-Tethered Pyrazolo[3,4-b]quinoline Hybrid Heterocycles
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The stereoselective syntheses of a library of novel spiro-tethered pyrazolo[3,4-b]quinoline-pyrrolidine/pyrrolothiazole/indolizine-oxindole/acenaphthene hybrid heterocycles have been achieved through the 1,3-dipolar cycloaddition of azomethine ylides generated in situ from α-amino acids and 1,2-diketones to dipolarophiles derived from pyrazolo[3,4-b]quinoline derivatives.
- Sumesh, Remani Vasudevan,Muthu, Muthumani,Almansour, Abdulrahman I.,Suresh Kumar, Raju,Arumugam, Natarajan,Athimoolam,Jeya Yasmi Prabha, E. Arockia,Kumar, Raju Ranjith
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supporting information
p. 262 - 270
(2016/06/01)
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- Preclinical Activity of New [1,2]Oxazolo[5,4-e]isoindole Derivatives in Diffuse Malignant Peritoneal Mesothelioma
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A series of 22 derivatives of the [1,2]oxazolo[5,4-e]isoindole system were synthesized through an efficient and versatile procedure that involves the annelation of the [1,2]oxazole moiety to the isoindole ring, producing derivatives with a wide substitution pattern. The structure-activity relationship indicates that the N-4-methoxybenzyl group appears crucial for potent activity. In addition, the presence of a 6-phenyl moiety is important and the best activity is reached with a 3,4,5-trimethoxy substituent. The most active compound, bearing both the structural features, was able to inhibit tumor cell proliferation at nanomolar concentrations when tested against the full NCI human tumor cell line panel. Interestingly, this compound was effective in reducing in vitro and in vivo cell growth, impairing cell cycle progression and inducing apoptosis, as a consequence of the inhibition of tubulin polymerization, in experimental models of diffuse malignant peritoneal mesothelioma (DMPM), a rapidly lethal disease, poorly responsive to conventional therapeutic strategies.
- Spanò, Virginia,Pennati, Marzia,Parrino, Barbara,Carbone, Anna,Montalbano, Alessandra,Cilibrasi, Vincenzo,Zuco, Valentina,Lopergolo, Alessia,Cominetti, Denis,Diana, Patrizia,Cirrincione, Girolamo,Barraja, Paola,Zaffaroni, Nadia
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p. 7223 - 7238
(2016/08/24)
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- MUTANT IDH1 INHIBITORS USEFUL FOR TREATING CANCER
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Compounds of Formula I and Formula II and the pharmaceutically acceptable salts thereof are disclosed The variables A, B, Y, Z, X1, X2, R1-4 and R13-18 are disclosed herein. The compounds are useful for treating cancer disorders, especially those involving mutant IDH1 enzymes. Pharmaceutical compositions containing compounds of Formula I or Formula II and methods of treatment comprising administering compounds of Formula I and Formula II are also disclosed.
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Paragraph 0120; 0175
(2016/07/27)
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- A facile, regioselective synthesis of pyrazolo[1, 5-a]pyrimidine analogs in the presence of KHSO4 in aqueous media assisted by ultrasound and their anti-inflammatory and anti-cancer activities
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Abstract: An environmentally benign, simple, efficient, and convenient route is described for the synthesis of novel pyrazolo[1,5-a]pyrimidine derivatives under ultrasound irradiation assisted by KHSO4 in aqueous medium. 3-(4-Methoxyphenyl)-3-o
- Kaping, Shunan,Kalita, Utpalparna,Sunn, Melboureen,Singha, Laishram Indira,Vishwakarma, Jai Narain
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p. 1257 - 1276
(2016/07/30)
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- Synthesis of 8,9-dihydro[1,2,4]triazolo[1,5-a]-quinazolin-6(7H)-one derivatives
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Regioselectivity of the reactions of 1H-1,2,4-triazol-3-amines with 2-acyl-5,5-dimethylcyclohexane-1,3-diones and 2-dimethylaminomethylidene-5,5- dimethylcyclohexane-1,3-dione was studied. In all cases, the products were substituted 8,9-dihydro[1,2,4]triazolo[1,5-a]quinazolin-6(7H)-ones whose structure was determined by 1H and 13C NMR spectroscopy.
- Petrov,Kasatochkin
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p. 502 - 507
(2013/07/04)
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- TRICYCLIC COMPOUNDS AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS
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The present invention describes and claims compounds of the Structural Formula (I), Structural Formula (II), or Structural Formula (III). In Formula (I), R1, R2, R3 and R3' are -H or methyl, or R3 and R3' taken together form a double bond, or R3' is -H and R2 and R3 taken together form a spiro-cyclopropyl substituent, R4 is -H or -F, and R5 is -H, methyl, -Cl or -Br. In Formula (II), R1 is -H, ethyl-, isopropyl-, cyclopropyl-, methyl- or methoxy-, R4 is -H or -F, and "Y" is: (a) -CH2-; (b) -CR6H-O-CR7R8-, wherein R6, R7, and R8 are independently -H or methyl; (c) -CR6H-N(R9)-CR7R8-, wherein R6, R7, and R8 are independently -H or methyl; (d) -CH2-C(R9)(R10)-C(R7)(R8)-, wherein R7, R8, R9 and R10 are independently -H or -methyl, or both R7 and R8 are -F, R9 and R10 are independently -H or -methyl, or both R9 and R10 are -F, or R9 and R10 taken together are (O=), which together with the carbon to which they are attached forms a carbonyl group.
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Page/Page column 20-21
(2012/02/02)
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- TRICYCLIC COMPOUNDS AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS
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The present invention describes and claims compounds of the Structural Formula I, Structural Formula II, or Structural Formula III: wherein R1, R2, R3 and R3' are -H or methyl, or R3 and R3 taken together form a double bond, or R3' is -H and R2 and R3 taken together form a spiro-cyclopropyl substituent, R4 is -H or -F, and R5 is -H, methyl, -CI or -Br, Formula II wherein R1 is -H, ethyl-, isopropyl-, cyclopropyl-, methyl- or methoxy-, R4 is -H or -F, and "Y" is: (a) -CH2-; (b) -CR6H-0-CR7R8-, wherein R6, R7, and R8 are independently - H or methyl; (c) -CR6H-N(R9)-CR7R8-, wherein R6, R7, and R8 are independently -H or methyl; (d) -CH2-C(R9)(R10)-C(R7)(R8)-, wherein R7, R8, R9 and R10 are independently - H or -methyl, or both R7 and R8 are -F, R9 and R10 are independently -H or -methyl, or both R9 and R10 are -F, or R9 and R10 taken together are (0=), which together with the carbon to which they are attached forms a carbonyl group.
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Page/Page column 21
(2012/02/02)
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- METABOTROPIC GLUTAMATE RECEPTOR MODULATORS
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The invention relates to heterocyclic derivatives as well as their pharmaceutically acceptable salts. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are mGluR5 modulators and are therefore useful for the control and prevention of acute and/or chronic neurological disorder
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Page/Page column 45-46
(2012/07/13)
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- Pathways for cyclizations of hydrazine-derived 2-(2-cyanovinyl)-3-oxo- cyclohex-1-ene enolates
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The introduction of a hydrazine functionality into 2-(2-cyanovinyl)-3-oxo- cyclohex-1-ene enolates results in their spontaneous cyclizations with participation of the hydrazine moiety. Depending on the reaction conditions used, the hydrazine-derived enola
- Yermolayev, Sergey A.,Gorobets, Nickolay Yu.,Shishkin, Oleg V.,Shishkina, Svetlana V.,Leadbeater, Nicholas E.
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experimental part
p. 2934 - 2941
(2011/05/13)
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- HETEROTRICYCLIC COMPOUNDS AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS
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The present invention relates to novel compounds of Formula (I), wherein wherein X1, X2, Y, Z1, Z2, Z3, M and (A)m are defined as in Formula (I); invention compounds are modulators of metab
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Page/Page column 26
(2010/08/04)
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- Novel Lactosamine Derivatives
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The present invention provides novel lactosamine derivatives and related methods suitable for the preparation, including large-scale production, of N-acetyllactosamine, lactosamine, numerous lactosamine salts and a number of lactosamine-containing oligosa
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Page/Page column 9
(2009/09/28)
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- An efficient synthesis of N1-substituted 2,5-dioxo-1,2,5,6,7,8-hexahydro-3-quinolinecarboxamide via enolate salts
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Various 2-(2-cyano-2-carbamoyl-1-ethenyl)-5,5-dimethyl-3-oxo-1-cyclohexen-1-olates substituted in the amide group with dialkylammonium or sodium cations were prepared via reactions of N-substituted cyanoacetamides with dimedone-DMFDMA adduct by a one-pot,
- Yermolayev, Sergey A.,Gorobets, Nikolay Yu.,Lukinova, Elena V.,Shishkin, Oleg V.,Shishkina, Svetlana?V.,Desenko, Sergey M.
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p. 4649 - 4655
(2008/09/20)
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- Synthesis of novel 3-(1,3-thiazol-2-yl)-7,8-dihydroquinoline-2,5(1H,6H)- diones
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An efficient method for the synthesis of novel 3-(1,3-thiazol-2-yl)-7,8- dihydroquinoline-2,5(1H,6H)-diones from various 2- dimethylaminomethylidenecyclohexane-1,3-diones, (1,3-thiazol-2-yl)acetonitriles, and dimethylformamide dimethyl acetal was developed. These transformations proceeded through intermediate 2-[2-(4-aryl-1,3-thiazol-2-yl)-2-cyanoethenyl]-3- oxocyclohex-1-en-1-olates. They were isolated as piperidinium salts and used in further heterocyclization reactions with aromatic amines, giving novel 1-aryl-3-(1,3-thiazol-2-yl)-7,8-dihydroquinoline-2,5(1H,6H)-diones. These compounds were also obtained by preparative three-step "one pot" synthesis under controlled microwave irradiation.
- Dzhavakhishvili,Gorobets,Chernenko,Musatov,Desenko
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experimental part
p. 422 - 427
(2009/06/05)
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- NOVEL LACTOSAMINE DERIVATIVES
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The present invention provides novel lactosamine derivatives and related methods suitable for the preparation, including large-scale production, of N-acetyllactosamine, lactosamine, numerous lactosamine salts and a number of lactosamine-containing oligosa
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Page/Page column 24
(2008/06/13)
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- Synthesis and structural study of tetrahydroindazolones
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Multinuclear magnetic resonance spectroscopy allowed us to characterize four 1(2),5,6,7-tetrahydro-4H-indazol-4-one derivatives (1-4) and establish the most stable tautomer in each case. The crystal structure of 6,6-dimethyl-1(2),5,6,7-tetrahydro-4H-indaz
- Claramunt, Rosa M.,López, Concepción,Pérez-Medina, Carlos,Pinilla, Elena,Torres, M. Rosario,Elguero, José
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p. 11704 - 11713
(2007/10/03)
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- Benzodipyrazoles: A new class of potent CDK2 inhibitors
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The synthesis and the preliminary expansion of this new class of CDK2 inhibitors are presented. The synthesis was accomplished using a solution-phase protocol amenable to rapid parallel expansion and suitable to be scaled-up in view of possible lead devel
- D'Alessio, Roberto,Bargiotti, Alberto,Metz, Suzanne,Brasca, M. Gabriella,Cameron, Alexander,Ermoli, Antonella,Marsiglio, Aurelio,Polucci, Paolo,Roletto, Fulvia,Tibolla, Marcellino,Vazquez, Michael L.,Vulpetti, Anna,Pevarello, Paolo
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p. 1315 - 1319
(2007/10/03)
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- Rapid microwave-assisted solution phase synthesis of substituted 2-pyridone libraries
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2-Pyridone and 2-quinolone analogues are well-known biologically active heterocyclic scaffolds. Libraries of 3,5,6-substituted 2-pyridone derivatives are generated by rapid microwave assisted solution phase methods using a one-pot, two-step protocol. The three-component condensation of CH-acidic carbonyl compounds, N,N-dimethylformamide dimethylacetal and methylene active nitriles, leads to 2-pyridones and fused analogues in moderate to good overall yields and high purities. The proposed mechanism of this novel multi-component reaction, structure elucidation of products and intermediates are discussed.
- Gorobets, Nikolay Yu.,Yousefi, Behrooz H.,Belaj, Ferdinand,Kappe, C. Oliver
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p. 8633 - 8644
(2007/10/03)
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- Enaminones as building blocks in heterocyclic syntheses: A new approach to polyfunctionally substituted cyclohexenoazines
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A variety of polyfunctionally substituted condensed pyridines and pyrazolotetrahydroquinazolines have been synthesized utilizing cyclic enaminones as starting materials.
- Al-Mousawi, Saleh,Abdelkhalik, Mervat Mohammed,John, Elizabeth,Elnagdi, Mohammed Hilmy
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p. 689 - 695
(2007/10/03)
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- Hydrolysis of N,N-dimethylenamines. Stereospecific synthesis of their enol and enol ester derivatives
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Stereospecific conversions of dimethylaminomethylidene group in various (Z)-alkyl 2-[(2,2-disubstituted ethenyl)amino]-3-dimethylaminopropenoates into their hydroxymethylidene and benzoyloxy methylidene derivatives were achieved in moderate to good yields. The difference between pathway to enol esters and (fused)pyrrole-2-carboxylate derivatives is clarified.
- Selic, Lovro,Grdadolnik, Simona Golic,Stanovnik, Branko
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p. 1317 - 1328
(2007/10/03)
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- Investigation of the One-Pot Synthesis of N-(5,6,7,8-Tetrahydro-7,7-dimethyl-2,5-dioxo-2H-1-benzopyran-3-yl)benzamide
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A detailed investigation of the reaction of hippuric acid (2) with dimedone (1) and triethyl orthoformate or other one-carbon sources in acetic anhydride yielding the benzopyran derivatives 3 and many byproducts is described.An explanation of this complex
- Kocevar, Marijan,Polanc, Slovenko,Vercek, Bojan,Tisler, Miha
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p. 501 - 503
(2007/10/02)
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- ACETALS OF LACTAMS AND ACID AMIDES. 48. REACTION OF ENAMINO DIKETONES WITH AMIDE ACETALS. SYNTHESIS OF DERIVATIVES OF COUMARIN AND CARBOSTYRIL
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It was established that the reaction of derivatives of 2-aminomethylenecyclohexane-1,3-dione with N,N-dimethyl-diethylacetal gives dienediamines, heating of which in aqueous hydrochloric acid leads, depending on the structure, to derivatives of carbostyri
- Grannik, V. G.,Shanazarov, A. K.,Solov'eva, N. P.,Chistyakov, V. V.,Persianova, I. V.,Sheinker, Yu. N.
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p. 1171 - 1177
(2007/10/02)
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- A New Aromatic Annelation Reaction with Two Synthons, Enaminones and 3-Oxoglutarate. Studies on the β-Carbonyl Compounds Connected with β-Polyketides. VIII
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Reactions of the enaminones 1 with dimethyl 3-oxoglutarate in the presence of KF-AcOH or AcONa-AcOH and 18-crown-6 gave the dimethyl 2-hydroxy-1,3-benzenedicarboxylates 3, providing a new aromatic annelation reaction.Keywords - enaminone; dimethyl 3-oxoglutarate; buffer catalysis; aromatic annelation; dimethyl 2-hydroxy-1,3-benzenedicarboxylate
- Takeuchi, Naoki,Okada, Naomi,Tobinaga, Seisho
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p. 4355 - 4359
(2007/10/02)
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- Reaction of 2-Dimethylaminomethylene-1,3-diones with Dinucleophiles. I. Synthesis of 1,5-Disubstituted 4-Acylpyrazoles
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Reaction of open-chain and cyclic sym-1,3-diones with N,N-dimethylformamide dimethyl acetal gave, generally in high yield, a series of sym-2-dimethylaminomethylene-1,3-diones which reacted with phenylhydrazine and methylhydrazine to afford, generally in satisfactory yield, a number of 1,5-disubstituted 4-acylpyrazoles.The applications and limits of this new pyrazole synthesis are presented and discussed.
- Schenone, Pietro,Mosti, Luisa,Menozzi, Giulia
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p. 1355 - 1361
(2007/10/02)
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- TRANSAMINATION OF TERTIARY ENAMINES, SYNTHESIS OF β-SUBSTITUTED N-BENZYLENAMINES
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The rate constants for the transamination of tertiary enamines by means of benzylamine were measured by polarography.The PMR spectra of the obtained compounds indicate the presence of strong intramolecular hydrogen bonds, due to the presence of the NH gro
- Granik, V. G.,Zhidkova, A. M.,Zhivotovskaya, I. S.,Solov'eva, N. P.,Polievktov, M. K.
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p. 2163 - 2166
(2007/10/02)
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- Proton Magnetic Resonance Studies of International Rotation, 10. Conformation and Stereodynamics of Dipolar Cyclic Enamines and Hydrazones
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2-Aminomethylene and 2-hydrazono derivatives 1-6 of carbocyclic and heterocyclic 1,3-dicarbonyl compounds which may form up to four rotational diastereoisomers were investigated by 1H and 13C NMR spectroscopy.The isomeric composition
- Koelle, Ulrich,Kolb, Bernd,Mannschreck, Albrecht
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p. 2545 - 2565
(2007/10/02)
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