Enantiocomplementary Total Asymmetric Syntheses of Prostaglandin A2
Both enantiomers of the racemic ketone (4) have been converted into (+)-PGA2 by utilizing two different synthetic pathways.In one route the reaction of the strained tricyclic ketone (8) with the cuprate reagent (9) was the critical step, while in the ' enantiocomplementary ' process the SN' reaction of the same cuprate reagent with the epoxide (16) was the crucial transformation.
Newton, Roger F.,Reynolds, Derek P.,Davies, John,Kay, Paul B.,Roberts, Stanley M,Wallace, Timothy W.
p. 683 - 686
(2007/10/02)
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