75122-52-0Relevant articles and documents
Preparation of 2-amino-5-alkyl -1, 3, 4-thiadiazole
-
Paragraph 0024-0026; 0052-0055, (2017/04/19)
The invention discloses a method for preparing 2-amino-5-alkyl-1,3,4-thiadiazole. The method comprises the following steps of adding A mol of thiosemicarbazide, B mol of carboxylic acid, C mol of phosphorus oxychloride and D mol of silica gel in a dry reaction container, grinding at a room temperature until the raw materials are completely reacted, and standing to obtain a crude product, wherein A: B: C = 1: (1 to 1.2): (1 to 1.2), and A: D = 1: (5 to 10); then adding alkaline solution in the crude product until the pH value of the obtained mixed solution is 8-8.2, then carrying out suction filtration on the mixed solution, dissolving the filter cake by a solvent and then further carrying out suction filtration, removing silica gel, then carrying out reduced pressure concentration on the finally-obtained filtrate, and removing the solvent to obtain 2-amino-5-alkyl-1,3,4-thiadiazole. The method disclosed by the invention is a solid-phase reaction, silica gel is used as a carrier, the operation process is simple, the reaction time is short, the reaction conditions are moderate, the equipment requirements are low, and the yield of the target product is up to more than 91%.
Preparation method and application of long carbon chain thiadiazole
-
Paragraph 0033; 0038; 0039, (2017/02/23)
The present invention belongs to the field of organic corrosion inhibitor. A preparation method of long carbon chain thiadiazole is as follows: (1) grinding carboxylic acid, thiosemicarbazide and a solid super acidic catalyst in a ball mill; (2) adding the ground mixture into a reaction flask, at heating with 500W microwave power auxiliary irradiation for 5-10 min, extracting the reaction mixture by using an organic solvent, recovering the solid super acid, concentrating to obtain a solid, conducting base precipitation, filtration and purification on the to solid obtain 2-amino-5-alkyl-1,3,4-thiadiazole. The solid super acidic catalyst has excellent catalytic activity, can avoid environmental pollution caused by concentrated sulfuric acid catalysis, and can be reused; by grinding, the starting materials are completely encased in the solid super acid, and react completely under microwave conditions; and the method has the advantages of short reaction time, high yield and easiness to operation control. The thiadiazole compound has corrosion inhibition effect on copper in an acidic medium, and maintains the inhibition effect of more than 90% under strong acid conditions.
A novel route to 1,2,4-triazoles
Kidwai, Mazaahir,Misra, Preeti,Bhushan, Kumar Ranjan,Dave, Bhavesh
, p. 3031 - 3040 (2007/10/03)
A novel synthetic method for the synthesis of 1,2,4-triazoles have been described starting from 1,3,4-thiadiazoles by adsorbing on acidic alumina under microwave irradiations (MWI).
