- Titanium(IV) Chloride-Mediated Stereoselective α-Alkylidenation to Efficiently Assemble Multisubstituted 1,3-Dienes
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A direct access to multisubstituted 1,3-dienes by α-exclusive alkylidenation of crotonic derivatives has been developed. This protocol, mediated by titanium tetrachloride chelation, features excellent regio- and stereoselectivity, mild reaction conditions, easy operation and wide substrate scope. Conversions of the derived dienes to other useful molecules were also explored. (Figure presented.).
- Sun, Rengwei,Song, Wei,Ma, Chunmei,Zhang, Huiwen,Yu, Xinhong
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supporting information
p. 3977 - 3982
(2016/12/30)
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- Development of general methods for the synthesis of new substituted allyl bromides as promising alkenylating agents
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A general procedure has been developed for the synthesis of hitherto unknown substituted allyl bromides. The procedure includes preparation of the corresponding α,β-unsaturated carboxylic acid esters from accessible ketones according to the Horner-Emmons
- Moskalenko,Boev
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p. 953 - 959
(2014/10/16)
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- Synthesis and biological activity of permethrinic acid analogs containing various substituents in position 2 of the cyclopropane ring
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A number of permethrinic acid ethyl ester derivatives having various substituents [Et, Pr, Ph, Ph(CH2) n (n = 1, 2), etc.] in position 2 of the cyclopropane ring were synthesized, and their insecticidal acivity against typhoid flies, rice weevils, and bean aphides, as well as juvenoid activity on flour beetle chrysalises, was studied. The newly synthesized compounds turned out to exhibit weak insecticidal activity against standard insects but pronounced juvenile hormone activity, which differentiates them from permethrinic acid esters.
- Mirzabekova,Kuz'mina,Lukashov,Sokolova,Golosov,Kazakov,Perlova,Potapova,Kheinman,Ivanova
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experimental part
p. 1139 - 1149
(2009/09/25)
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- TMSCl-mediated catalytic carbocupration of alkynoates: An unprecedented and remarkable effect of catalyst loading on highly selective stereochemical induction via a TMS-allenoate intermediate
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The TMSCl-mediated catalytic carbocupration of alkynoates has been investigated. It has been shown that catalyst loadings as low as 30 mol% readily allow for high yields and diastereoselectivities for a series of Grignard reagents. In addition, an unprecedented and remarkable effect of catalyst loading on stereochemical induction has been observed. ( Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004).
- Jennings, Michael P.,Sawant, Kailas B.
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p. 3201 - 3204
(2007/10/03)
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- Thioepoxide formation by ring closure of allylthiyl radicals - A novel rearrangement of allylic thionitrites
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Tertiary allylic thionitrites undergo thermal rearrangement to α,β-episulfide nitroso dimers via ring closure of allylthiyl radicals.
- Cavero, Marta,Motherwell, William B.,Potier, Pierre,Weibel, Jean-Marc
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p. 2394 - 2395
(2007/10/03)
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- Carbon-Carbon Bond Formation at the γ-position of Dienolates via the Palladium Catalysed Coupling of the Tin Masked Dienolates
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The palladium catalysed coupling reaction of the tin masked dienolate (2) with organic halides takes place at the position substituted by tin, thereby providing a new method for C-C bond formation at the γ-position of dienolates.
- Yamamoto, Yoshiri,Hatsuya, Satoshi,Yamada, Jun-ichi
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