cas 75438-54-9, 4,6-DICHLORO-2-METHYL-5-(1-ACETYL-2-IMIDAZOLIN-2-YL)-AMINOPYRIDINE | Articles data ｜lookchem

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75438-54-9

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Process for the preparation of moxonidine
The present invention provides an improved process for the preparation of 4,6-dichloro-2-methyl-5-(1-acetyl-2-imidazolin-2-yl)aminopyrimidine. The present invention also provides an improved process for the preparation of moxonidine. The present invention further provides a process for the purification of moxonidine.
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Paragraph 0036

(2013/05/09)

MOXONIDINE ANALOGS, PREPARATION PROCESSES AND USES THEREFOR
The present invention provides derivatives of moxonidine, 1-[l-[(4,6-dichloro-2-methyl-6-5-pyrimidinyl)imino]ethyl]-2-imidazolidinone of formula (V) and l-[l-[(4-chloro-2-methyl-6-methoxy-5-pyrimidinyl)imino]ethyl]-2-imidazolidinone of formula (VI), which can be used for testing the purity or monitoring the production of moxonidine, and process for preparing the derivatives. Also provided is an improved process for preparing 4,6- dichloro-2-methyl-5-(l-acetyl-2-imidazolin-2-yl)-aminopyrimidine (DMAIA) and a method of utilizing the process to produce moxonidine.
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Page/Page column 12-13

(2008/12/06)

Substituted aminopyrimidines
The present invention is directed to certain aminopyrimidines of the general formula STR1 wherein R1, R2, and R3 are hydrogen, halogen, alkoxy, alkylthio, or alkyl having 1 to 4 carbon atoms, or cycloalkyl having 3 to 5 carbon atoms and R4 is hydrogen or an aliphatic or aromatic acyl group, as well as physiologically compatible acid addition salts thereof. Compounds of the present invention are useful as blood pressure lowering agents and in the treatment of glaucoma.
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(2008/06/13)

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Chemical Properties

Boiling Point: 394.7 °C at 760 mmHg
Flash Point:192.5 °C
Density: 1.59 g/cm³
Storage Temp.:2-8°C
PKA: 0.41±0.20(Predicted)
PSA: 57.59000
LogP: 1.77330

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