75439-01-9Relevant articles and documents
Improved process for producing moxonidine
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Page/Page column 6, (2008/06/13)
The present invention provides improved process for production of highly pure Moxonidine comprising reacting the starting material 6-dichloro-2-methyl-5-(1-acetyl-2-imidazolin-2-yl)-aminopyrimidine (DMAIA) with different bases (e.g., sodium hydroxide or potassium hydroxide), thus avoiding the use of sodium methoxide while carrying out the reaction at milder conditions. While using sodium methoxide, is not needed to use methanol as solvent and a more friendly class 3 solvent (e.g., DMSO) is used instead. The reaction may be carried out at ambient temperature and it is not necessary to use two-fold excess of the base as about 1.0-1.1 molar excess of sodium methoxide in relation to DMAIA is sufficient.
The use of moxonidine salts for purification of moxonidine
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Page/Page column 7-8, (2008/06/13)
The present invention provides crystalline Moxonidine salts e.g., mono-Moxonidine oxalate and mono-Moxonidine formate. Also provided by the present invention is a novel purification process of Moxonidine using these crystalline Moxonidine salts. By precipitating a Moxonidine salt from the reaction mixture and reacting it with a base, highly pure crystalline Moxonidine base is obtained in high yield.
