75499-44-4 Usage
Uses
Used in Pharmaceutical Industry:
Argpressin acetate is used as a vasoconstrictor for increasing blood pressure in cases of septic shock, which is a form of vasodilatory hypotension. Its ability to regulate water balance and produce vasoconstriction makes it a valuable compound in the treatment of certain medical conditions.
Used in Research and Development:
Argpressin acetate is also used as a research tool to study the effects of V1a receptor agonists on vascular smooth muscle cell contraction and other related physiological processes. This helps in understanding the underlying mechanisms of various diseases and developing targeted therapies.
Used in Diagnostic Applications:
Due to its role in regulating water balance and blood pressure, Argpressin acetate can be used in diagnostic applications to assess the functionality of the posterior pituitary and median eminence, as well as the overall health of the central nervous system.
Check Digit Verification of cas no
The CAS Registry Mumber 75499-44-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,5,4,9 and 9 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 75499-44:
(7*7)+(6*5)+(5*4)+(4*9)+(3*9)+(2*4)+(1*4)=174
174 % 10 = 4
So 75499-44-4 is a valid CAS Registry Number.
75499-44-4Relevant articles and documents
NEW SYTHESIS OF VASOPRESSIN AND ITS DE-9-GLYCINE ANALOGS
Panseuvich, O. S.,Chipens, G. I.,Korps, A. O.,Pavar, A. P.
, p. 370 - 375 (2007/10/02)
A unified scheme is proposed for the synthesis of vasopressin (I), de-9-glycinevasopressin (II), and de-9-glycinamidevasopressin (III) which has been developed on the basis of the tetrapeptide Glm-Asn-Cys(Bzl)-Pro and other homologous fragments of neurohypophyseal hormones as common initial and intermediate compounds.The free dithiols obtained by the reduction of protected derivatives of (I)-(III) by sodium in liquid ammonia have been oxidized to the corresponding cyclic disulfides (I)-(III) with the aid of 1 M H2O2 at 0-5 deg C and pH (8.5.The vasopressor activities of (I)-(III) a re, respectively 470 +/- 20, 1.7, and 0.5 IU/mg (rat, in vivo).
