- Sulfuryl Chloride Promoted gem -Dichlorination-Dehydrochlorination in Alkyl Benzothiazinylacetates: Synthesis of the Skeleton of Trichochrome Pigments
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Chemo- and stereoselective total synthesis of the basic trichochrome skeleton is described starting from o-aminothiophenol and maleic anhydride in very good overall yield. The process involves the synthesis of the corresponding 1,4-benzothiazin-2-ylacetates followed by their sulfuryl chloride induced dihalogenation-dehydrohalogenation and a second condensation with o-aminothiophenol as key steps.
- Jangir, Ravi,Gadre, Smita R.,Argade, Narshinha P.
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p. 2631 - 2634
(2015/09/01)
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- Ultrasound and microwave assisted rapid and sustainable route to synthesis of benzothiazine derivatives
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Ultrasound and microwave assisted synthesis of 2-Meldrum- 2H,4H-2-carbonyl methyl-3-oxo-1,4-benzothiazine 10, 2-dimidone- 2H,4H-2-carbonyl methyl-3-oxo-1,4-benzothiazine 11, 2H,4H-2-amino-[3-methyl pyrazol-5-one-1-yl]- carbonyl methyl- 3-oxo-1,4-benzothia
- Dabholkar, Vijay V.,Gavande, Rahul P.
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p. 1173 - 1179,7
(2020/08/31)
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- A facile and rapid synthesis of benzothiazines
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A series of 2H. 4H-2-[3-methyl-4-(substituted) phenyl azo pyrazolon-5-one-1-yl]-carbonyl methyl-3-oxo-1,4-benzothiazines have been synthesized by the reaction of 2H, 4H-2-hydrazino carbonyl methyl-3-oxo-1,4- benzothiazine with substituted acetoacetic ester derivatives using ultrasound and microwave irradiation. All the synthesized compounds were investigated for their antibacterial activities. The result indicated that the compounds showed convincing activities against Gram-positive bacteria (Bacillus subtilis and Streptococcus lactis) when compared with standard drug (ampicillin trihydrate). These compounds were also synthesized by conventional method and their structures have been elucidated on the basis of spectral analyses and chemical analysis.
- Dabholkar, Vijay V.,Gavande, Rahul P.
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p. 365 - 368
(2013/09/24)
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- Ultrasound and microwave assisted synthesis of benzothiazines
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Ultrasound and microwave assisted synthesis of 2-meldrum-2H, 4H-2-carbonyl methyl-3-oxo-1,4-benzothiazine (10), 2-dimidone 2H, 4H-2-carbonyl methyl-3-oxo-1,4-benzothiazine (11), 2H, 4H-2-amino-i3-methyl pyrazol-5-one-1-yl]-carbonyl methyl-3-0X0-1,4-benzot
- Dabholkar, Vijay V.,Gavande, Rahul P.
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p. 359 - 364
(2013/09/24)
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- PEPTIDE DEFORMYLASE INHIBITORS
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Benzothiazine compounds of the general formula (I) and pharmaceutically acceptable salts or esters thereof are peptide deformylase inhibitors useful in the treatment or prevention of infections and other diseases in which peptide deformylases are involved
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Page/Page column 28
(2008/06/13)
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- Reactions of Cyclic Anhydrides: Part VIII - Formation of 2-Oxobenzothazines from o-Aminothiophenol and Maleic Anhydride Derivatives
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Reaction of o-aminothiophenol (o-ATP) with maleic anhydride, maleic acid or fumaric acid furnishes 2-(oxobenzothiazinyl)acetic acid (Ia); with methyl hydrogenmaleate or methyl hydrogenfumarate, a mixture of Ia and its methyl ester Ib (80 : 20 and 65 : 35
- Wagh, S. B.,Shaikh, A. S.,Balasubramaniyan, V.
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p. 868 - 871
(2007/10/02)
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