7556-63-0

Basic information

• Product Name: METHYL (2H-1 4-BENZOTHIAZIN-3(4H)-ONE-2&
• Synonyms: METHYL (2H-1 4-BENZOTHIAZIN-3(4H)-ONE-2&;Methyl 3,4-dihydro-3-oxo-2H-1,4-benzothiazine-2-acetate, 98%;Methyl 3-oxo-3,4-dihydro-2H-1,4-benzothiazine-2-acetate, 98%;METHYL 2,3-DIHYDRO-3-OXO-4H-1,4-BENZOTHIAZINE-2-ACETATE;methyl 2-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-2-yl)acetate;(3-Oxo-3,4-dihydro-2H-benzo[1,4]thiazin-2-yl)-acetic acid methyl ester
• CAS NO: 7556-63-0
• Molecular Formula: C₁₁H₁₁NO₃S
• Molecular Weight: 237.27
• Product Categories: Building Blocks;Heterocyclic Building Blocks;Thiazines
• Mol File: 7556-63-0.mol
• Article Data: 6

Chemical Properties

• Melting Point: 143-147 °C(lit.)
• Boiling Point: 410 °C at 760 mmHg
• Flash Point: 201.8 °C
• Appearance: /solid
• Density: 1.276 g/cm³
• Vapor Pressure: 6.23E-07mmHg at 25°C
• Refractive Index: 1.572
• CAS DataBase Reference: METHYL (2H-1 4-BENZOTHIAZIN-3(4H)-ONE-2&(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL (2H-1 4-BENZOTHIAZIN-3(4H)-ONE-2&(7556-63-0)
• EPA Substance Registry System: METHYL (2H-1 4-BENZOTHIAZIN-3(4H)-ONE-2&(7556-63-0)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 7556-63-0(Hazardous Substances Data)

Usage

General Description

Methyl (2H-1,4-benzothiazin-3(4H)-one-2) is a chemical compound with the molecular formula C8H7NOS. It is a derivative of benzothiazine and belongs to the class of organic compounds known as benzothiazinones. METHYL (2H-1 4-BENZOTHIAZIN-3(4H)-ONE-2& is of interest in medicinal chemistry due to its potential as a biological active agent. It has been studied for its potential pharmacological properties, including its antitubercular activity. Further research is needed to fully understand the biological effects and potential applications of this compound.

InChI:InChI=1/C11H11NO3S/c1-15-10(13)6-9-11(14)12-7-4-2-3-5-8(7)16-9/h2-5,9H,6H2,1H3,(H,12,14)

Upstream product

• 624-48-6 dimethyl cis-but-2-ene-1,4-dioate 
• 137-07-5 2-amino-benzenethiol 
• 624-49-7 dimethylfumarate 
• 3052-50-4 monomethyl maleate 
• 2756-87-8 methyl hydrogen fumarate 
• 67-56-1 methanol 
• 6270-74-2 3-oxo-1,4-benzothiazin-2-ylacetic acid 
• 108-31-6 maleic anhydride 

Downstream Products

• 1334714-22-5 2-dimidone-2H,4H-2-carbonylmethyl-3-oxo-1,4-benzothiazine 
• 1333221-29-6 C₂₁H₁₉N₅O₃S 
• 1333221-28-5 C₂₁H₁₉N₅O₄S 
• 1333221-32-1 C₂₀H₁₇N₅O₃S 
• 1333221-31-0 C₂₀H₁₆N₆O₅S 
• 1333221-30-9 C₂₀H₁₆ClN₅O₃S 
• 2833-04-7 (+/-)-1-(2-Hydroxy-ethyl)-3,3a-dihydro-1H-pyrrolo<3.2-b><1.4>benzothiazin-2-on 
• 3201-13-6 (+/-)-1-Ethyl-3,3a-dihydro-1H-pyrrolo<3.2-b><1.4>benzothiazin-2-on 
• 2833-01-4 (+/-)-3,3a-Dihydro-1H-pyrrolo<3.2-b><1.4>benzothiazin-2-on 
• 2694-33-9 [3-(4-methoxy-anilino)-2H-benzo[1,4]thiazin-2-yl]-acetic acid methyl ester 
• 2833-05-8 1-(2-phenylcarbamoyloxy-ethyl)-3,3a-dihydro-1H-benzo[b]pyrrolo[2,3-e][1,4]thiazin-2-one 
• 2694-32-8 1-(4-methoxy-phenyl)-3,3a-dihydro-1H-benzo[b]pyrrolo[2,3-e][1,4]thiazin-2-one 

Relevant articles and documents

Sulfuryl Chloride Promoted gem -Dichlorination-Dehydrochlorination in Alkyl Benzothiazinylacetates: Synthesis of the Skeleton of Trichochrome Pigments

Chemo- and stereoselective total synthesis of the basic trichochrome skeleton is described starting from o-aminothiophenol and maleic anhydride in very good overall yield. The process involves the synthesis of the corresponding 1,4-benzothiazin-2-ylacetates followed by their sulfuryl chloride induced dihalogenation-dehydrohalogenation and a second condensation with o-aminothiophenol as key steps.

A facile and rapid synthesis of benzothiazines

A series of 2H. 4H-2-[3-methyl-4-(substituted) phenyl azo pyrazolon-5-one-1-yl]-carbonyl methyl-3-oxo-1,4-benzothiazines have been synthesized by the reaction of 2H, 4H-2-hydrazino carbonyl methyl-3-oxo-1,4- benzothiazine with substituted acetoacetic ester derivatives using ultrasound and microwave irradiation. All the synthesized compounds were investigated for their antibacterial activities. The result indicated that the compounds showed convincing activities against Gram-positive bacteria (Bacillus subtilis and Streptococcus lactis) when compared with standard drug (ampicillin trihydrate). These compounds were also synthesized by conventional method and their structures have been elucidated on the basis of spectral analyses and chemical analysis.

PEPTIDE DEFORMYLASE INHIBITORS

Benzothiazine compounds of the general formula (I) and pharmaceutically acceptable salts or esters thereof are peptide deformylase inhibitors useful in the treatment or prevention of infections and other diseases in which peptide deformylases are involved