- PYRAZOLE DERIVATIVES AS S1P1 AGONISTS
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The present invention relates to a compound of formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by sphingosine-1-phosphate receptors (S1P1) agonists.
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Page/Page column 36
(2011/12/04)
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- New pyrazole derivatives
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The present invention relates to a compound of formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by sphingosine-1-phosphate receptors (S1P1) agonists.
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Paragraph 0141; 0142
(2013/03/26)
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- Selected Cgrp-Antagonists, Processes for Preparing Them and Their Use as Pharmaceutical Compositions
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The invention relates to CGRP-antagonists of general formula (I), wherein R1, R2, R3, R4 and R5 are defined in claim 1, to the tautomers, isomers, diastereomers, enantiomers, hydrates, mixtures salts and salt hydrates thereof, in particular to 10 salts thereof, which are physiologically compatible with acids or inorganic or organic bases and to compounds of general formula (I), wherein one or several hydrogen atoms are substituted by deuterium. Drugs containing said compounds, the use thereof and a method for the production thereof are also disclosed.
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Page/Page column 59-60
(2008/12/08)
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- Selected CGRP antagonists, process for their preparation as well as their use as medicaments
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Heterocyclic esters (I), their tautomers, diastereomers, enantiomers, hydrates, mixtures and (hydrated) salts, particularly physiologically acceptable salts with (in)organic acids and bases, that are antagonists of calcitonin gene-related peptide (CGRP) a
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- Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions
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The present invention relates to the CGRP-antagonists of general formula I wherein R1, R2, R3 and R4 are defined as in claim 1, the tautomers, the isomers, the diastereomers, the enantiomers, the hydrates thereof, the mixtures thereof and the salts thereof and the hydrates of the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, as well as those compounds of general formula I wherein one or more hydrogen atoms are replaced by deuterium, pharmaceutical compositions containing these compounds, their use and processes for preparing them.
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Page/Page column 104
(2008/06/13)
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- CGRP ANTAGONISTS, METHOD FOR THE PRODUCTION THEREOF, AND THEIR USE AS MEDICAMENTS
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The invention relates to CGRP antagonists of general formula (I) in which: R1, R2, R3, R4 and X are defined as in Claim 1, to their tautomers, isomers, diastereomers, enantiomers, hydrates, mixtures and salts as well as the hydrates of the salts, in particular, their physiologically compatible salts with inorganic or organic acids and bases, and those compounds of general formula (I) in which one or more hydrogen atoms are replaced by deuterium. The invention also relates to medicaments containing these compounds, the use thereof, and to methods for producing them.
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- Dihalopropene compounds, their use as insecticides/acaricides and intermediates for their production
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PCT No. PCT/JP97/00141 Sec. 371 Date Jun. 12, 1998 Sec. 102(e) Date Jun. 12, 1998 PCT Filed Jan. 1, 1997 PCT Pub. No. WO97/28112 PCT Pub. Date Aug. 7, 1997Dihalopropene compounds of the general formula: wherein R1 is substituted alkyl; R2, R3 and R4 are e
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- Dihalopropene compounds, insecticidal/acaricidal agents containing same, and intermediates for their production
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The dihalopropene compounds of the general formula ?I! have excellent insecticidal/acaricidal activity, so that they are satisfactorily effective for the control of noxious insects, mites and ticks.
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- Dihalopropene compounds, insecticides containing them as active ingredients, and intermediates for their production
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The present invention provides dihalopropene compounds of the general formula: STR1 wherein R1 is C1 -C10 alkyl or the like; L is C(=O)NH or the like; R2, R3 and R4 are independently haloge
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