A scalable approach for the cyanosilation of benzaldehydes and acetophenones using indium trichloride, a versatile, user friendly catalyst is developed. Cyanohydrin trimethylsilyl ethers are converted in the same pot to α-fluorophenyl acetonitriles which
Shewalkar, Mukesh P.,Reddy, B. Veera Bhadra,Shinde, Devanand B.
p. 222 - 226
(2015/06/23)
Synthesis of β-fluorophenethyl halopyridyl thiourea compounds as non-nucleoside inhibitors of HIV-1 reverse transcriptase
Synthesis of β-fluorophenethylamines was accomplished in three steps with an overall yield of 50%. Condensation of β-fluorophenethylamine hydrochloride with thiocarbonylimidazole derivative derived from halopyridyl amines in dimethylformamide furnished the desired thiourea compounds as crystalline solids. Several of the β-fluorophenethyl thiourea compounds inhibited HIV-1 reverse transcriptase (RT) at nanomolar to low micromolar concentrations.
Venkatachalam,Uckun
p. 2463 - 2472
(2007/10/03)
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