756846-54-5

Usage

Type of compound

Nitrile compound

Structure

A 2-fluoroacetonitrile group attached to a 2-chlorophenyl group

Uses

Intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds; used in organic synthesis and as a reagent in chemical reactions

Toxicity

Potential toxic properties

Irritancy

Potential irritant properties

Handling precautions

Should be handled and used with caution in laboratory and industrial settings.

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 89-98-5 2-chloro-benzaldehyde 
• 66985-47-5 2-chloro-α-[(trimethylsilyl)oxy]benzeneacetonitrile 

Relevant academic research and scientific papers

Synthesis and reduction of α-fluoroacetonitriles

A scalable approach for the cyanosilation of benzaldehydes and acetophenones using indium trichloride, a versatile, user friendly catalyst is developed. Cyanohydrin trimethylsilyl ethers are converted in the same pot to α-fluorophenyl acetonitriles which

Synthesis of β-fluorophenethyl halopyridyl thiourea compounds as non-nucleoside inhibitors of HIV-1 reverse transcriptase

Synthesis of β-fluorophenethylamines was accomplished in three steps with an overall yield of 50%. Condensation of β-fluorophenethylamine hydrochloride with thiocarbonylimidazole derivative derived from halopyridyl amines in dimethylformamide furnished the desired thiourea compounds as crystalline solids. Several of the β-fluorophenethyl thiourea compounds inhibited HIV-1 reverse transcriptase (RT) at nanomolar to low micromolar concentrations.