Exploiting intramolecular hydrogen bonding for the highly (: Z)-selective & metal free synthesis of amide substituted β-aminoenones
Herein, we report the metal free and intramolecular hydrogen bonding (IMHB) directed (Z)-selective synthesis of amide substituted β-aminoenones. Systematically, we confirm the role of dual IMHB (CO?H-N) on the Z-direction using single-crystal X-ray analysis and 1D and 2D NMR studies. High stereoselectivity, atom efficiency, excellent yields and high purity are achieved by mere filtration. We avoid column purification and the formed by-product in the process is environmentally friendly.
TREATMENT OF PLATELET DERIVED GROWTH FACTOR RELATED DISORDERS SUCH AS CANCERS
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(2008/06/13)
Treatment of platelet derived growth factor-related disorders such as cancers.
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(2014/12/12)
Synthesis and immunosuppressant activity of pyrazole carboxamides
A series of novel pyrazole carboxamides sis disclosed that demonstrate strong immunosuppressant activity in rodent and human mixed leukocyte response (MLR) assays (IC50 1 μM). The synthesis, biological activity, mode of action, and pharmacokinetic properties of this new lead series are discussed.
Wang, Alan X.,Xie, Qinghua,Lane, Ben,Mollison, Karl W.,Hsieh, Gin C.,Marsh, Kennan,Sheets, Michael P.,Luly, Jay R.,Coghlan, Michael J.
p. 2787 - 2792
(2007/10/03)
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