cas 75808-54-7, N-(Sodiothiocarbonothioyl)-L-glutamic acid disodium salt

Articles about 75808-54-7Total 2 be found

Optimization of rhodanine scaffold for the development of protein-protein interaction inhibitors
Abstract Searching for novel protein-protein interactions inhibitors (PPIs) herein we describe the identification of a new series of rhodanine derivatives. The selection was performed by means virtual-screening, docking studies, Molecular Dynamic (MD) sim
Ferro, Stefania,De Luca, Laura,Agharbaoui, Fatima Ezzahra,Christ, Frauke,Debyser, Zeger,Gitto, Rosaria
p. 3208 - 3214
(2015)
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Synthesis and evaluation of aryl thioxothiazolidinone inhibitors of ADAMTS-5 (Aggrecanase-2)
5-Benzylidene-2-thioxo-thiazolidin-4-one inhibitors of ADAMTS-5 (Aggrecanase-2) have been prepared via commercially available starting materials. The identified compounds show micromolar ADAMTS-5 potency and demonstrate SAR trends for both the aryl group and thioxothiazolidinone zinc chelator. This series of compounds represents steps toward a metalloprotease inhibitor as a disease-modifying osteoarthritis drug.
Bursavich, Matthew G.,Gilbert, Adam M.,Lombardi, Sabrina,Georgiadis, Katy E.,Reifenberg, Erica,Flannery, Carl R.,Morris, Elisabeth A.
p. 1185 - 1188
(2008/02/01)

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