760-30-5

Basic information

• Product Name: 2-sulfanylacetohydrazide
• Synonyms: 2-sulfanylacetohydrazide;MERCAPTOACETICACIDHYDRAZIDE
• CAS NO: 760-30-5
• Molecular Formula: C₂H₆N₂OS
• Molecular Weight: 106.15
• Mol File: 760-30-5.mol

Chemical Properties

• Boiling Point: 336.5°C at 760 mmHg
• Flash Point: 157.3°C
• Appearance: /
• Density: 1.245g/cm³
• Vapor Pressure: 0.000112mmHg at 25°C
• Refractive Index: 1.531
• CAS DataBase Reference: 2-sulfanylacetohydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-sulfanylacetohydrazide(760-30-5)
• EPA Substance Registry System: 2-sulfanylacetohydrazide(760-30-5)

Safety Data

• Hazardous Substances Data: 760-30-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C2H6N2OS/c3-4-2(5)1-6/h6H,1,3H2,(H,4,5)

Upstream product

• 623-51-8 ethyl 2-sulfanylacetate 
• 2365-48-2 Methyl thioglycolate 

Downstream Products

• 6854-84-8 2,2′-disulfanediyldi(acetohydrazide) 
• 133662-03-0 Mercapto-acetic acid [1-(2-chloro-phenyl)-eth-(E)-ylidene]-hydrazide 

Relevant articles and documents

Interactive Aggregation-Induced Emission Systems Controlled by Dynamic Covalent Chemistry

Aggregation-induced emission (AIE) molecules show all kinds of application in biological research, chemical sensing, and medical study. However, most of the reported molecules are based on the performance of the single molecular entity. In this paper, a molecular system for real-time sensing through combination of dynamic covalent chemistry and aggregation-induced emission was rationally designed and tested. The aggregated particles exhibit different fluorescence emission colors upon the addition of various kinds of chemical reagents. The LC-MS analysis reveals that the breakage, formation, and exchange of the disulfide bonds in the molecular system occur spontaneously upon different reagents (base/acid and cysteine), which leads to a change in the proportion of different components in the system accordingly. Meanwhile, the fluorescence emission of the AIE system exhibits blue/red shift accompanied by intensity changes. Moreover, the particle size of the aggregated molecules gradually increased with the change of the chemical environment, which could be the result of the nucleus growing through intermolecular hydrogen bonding among molecular components. Thus, the chemical environment change results in the interactions of molecules, which further leads to the variation of dynamic fluorescence emission and morphology. The result represents a promising future for a dynamic AIE molecular system in the bioimaging and sensing study.

Synthesis and pharmacological evaluation of thieno[2,3-b]pyridine derivatives as novel c-Src inhibitors

Among the recently investigated targets for cancer therapy is the c-Src non-receptor tyrosine kinase. Indeed research around deregulated activity of this enzyme has proven its role in tumor progression, while the beneficial effects of c-Src inhibitors in several pathological models has also been demonstrated. We report here the preparation and pharmacological profile of a novel series of c-Src inhibitors that was elaborated around a 3-amino-thieno[2,3-b]pyridine discovered during an HTS campaign. c-Src enzyme inhibition and c-Src inhibition were investigated in a series of related compounds derived from the initial hit. Molecular modeling as well as X-ray studies on one active compound allowed us to hypothesize on ligand orientation and interactions within the ATP hydrophobic pocket. Design and synthesis of structural analogs then led to new ligands possessing quite efficient enzymatic and c-Src inhibition. The structure-activity elements disclosed in this study shed light on the role played by substituents on the thienopyridine ring as well as the impact of other aromatic moieties in the molecule when interacting with the enzyme.