- Design, synthesis and evaluation of novel 5,6-dimethoxy-1-oxo-2,3-dihydro-1H-2-indenyl-3,4-substituted phenyl methanone analogues
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In present investigation, a series of substituted phenyl-5,6-dimethoxy-1-oxo-2,3-dihydro-1H-2-indenylmethanone analogues were synthesized and were tested for their potential for treating AD disease. All the newly synthesized compounds were showing moderate to high AChE inhibitory activities, with compound 5,6-dimethoxy-1-oxo-2,3-dihydro-1H-2-indenyl-3,4,5-trimethoxyphenylmethanone (5f) produced significant activities with 2.7 ± 0.01 μmol/L.
- Ali, Mohamed Ashraf,Yar, Mohammad Shahar,Hasan, Mohamed Zaheen,Ahsan, Mohamed Jawed,Pandian, Suresh
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scheme or table
p. 5075 - 5077
(2010/03/24)
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- Synthesis and antimycobacterial evaluation of novel 5,6-dimethoxy-1-oxo-2,5-dihydro-1H-2-indenyl-5,4-substituted phenyl methanone analogues
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In present investigation, a series of substituted phenyl-5,6-dimethoxy-1-oxo-2,5-dihydro-1H-2-indenylmethanone analogues were synthesized and were evaluated for antimycobacterial activity against Mycobacterium tuberculosis H37Rv and INH resistant M. tuberculosis. All the newly synthesized compounds were showing moderate to high inhibitory activities. The compound 5,6-dimethoxy-1-oxo-2,5-dihydro-1H-2-indenyl-4-fluorophenylmethanone (5g) was found to be the most promising compounds active against M. tuberculosis H37Rv and isoniazid (INH) resistant M. tuberculosis with Minimum inhibitory concentration 0.10 and 0.10 μM.
- Ali, Mohamed Ashraf,Samy, Jeyabalan Govinda,Manogaran, Elumalai,Sellappan, Velmurugan,Hasan, Mohamed Zaheen,Ahsan, Mohamed Jawed,Pandian, Suresh,ShaharYar, Mohammad
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scheme or table
p. 7000 - 7002
(2010/06/16)
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- Synthesis and biological evaluation of 4′-(6,7-disubstituted-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-biphenyl-4-ol as potent Chk1 inhibitors
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A new series of potent tricyclic pyrazole-based Chk1 inhibitors are described. Analogues disubstituted on the 6- and 7-positions show improved Chk1 inhibition potency compared with analogues with a single substituent on either the 6- or 7-position. Based
- Tao, Zhi-Fu,Li, Gaoquan,Tong, Yunsong,Chen, Zehan,Merta, Philip,Kovar, Peter,Zhang, Haiying,Rosenberg, Saul H.,Sham, Hing L.,Sowin, Thomas J.,Lin, Nan-Horng
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p. 4308 - 4315
(2008/02/09)
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