Synthesis of 4-Substituted 11-Phenyl-1,2,3,4-tetrahydro-5H-azepinoquinolin-5-one Derivatives as Potential Peripheral Benzodiazepine-Receptor Ligands
The synthesis of semirigid analogs of PK 11195, the highly specific peripheral benzodiazepine-receptor ligand, is reported.Compound (4) underwent the Wittig reaction with acetaldehyde to give olefin (7) which after allylic bromination was aminated to give