- Nitrogen-containing, fluoroalkyl sulfonyl chloride method for the preparation of (by machine translation)
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The invention discloses a nitrogen-containing, fluoroalkyl sulfonyl chloride method for preparing, by containing nitrogen/perfluoroalkyl alcohol as the raw material, under the alkaline condition and a sulfonyl chloride the reaction produces the corresponding nitrogen-containing/perfluoroalkyl sulfonate ester, then nitrogen-containing/perfluoroalkyl sulfonate ester with a thio acetic acid potassium generating affinity substitution reaction to produce the nitrogen-containing/Fluoalkyl thiophosphoro acetate, then the chlorine treatment to obtain nitrogen-containing/fluoroalkyl sulfonyl chloride. The synthesis of this invention containing nitrogen (fluoro) alkyl sulfonyl chloride, the compound is a drug, pesticide research and development and production of important pharmaceutical intermediate, the compound of preparation of the alkyl sulfonyl chloride synthesis of pharmaceutical intermediates database, to the market to provide alkyl sulfonyl chloride can be synthetic fragment. Raw materials used in the present invention chemical reagent is commercially available, low cost, short synthetic route, high yield, high product purity chemical, provides high-purity products, so as to obtain higher economic benefits. (by machine translation)
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Paragraph 0023; 0037; 0038
(2016/10/10)
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- SYNTHESIS OF THREE PARTIALLY FLUORINATED ALKANESULFONIC ACIDS AS POTENTIAL FUEL-CELL ELECTROLYTES.
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The simple and effective syntheses of CH//2FCH//2SO//3H, CF//3CH//2SO//3H, AND CHF//2CF//2CH//2SO//3H have been achieved with 18. 8%, 34. 1%, and 33. 7% overall yields. The low molecuar weight partially fluorinated alkanesulfonic acids containing alpha -methylene groups can be prepared from the p-toluenesulfonates of the corresponding alcohols, via a reaction with benzyl mercaptan, followed by an oxidative chlorination of the resulting sulfides, with subsequent hydrolysis of the sulfonyl chloride. The reaction of partially fluorinated alkyl halides with sodium sulfite (Strecker's method) proved to be inefficient (very low yields) and unreliable. The sulfonate salts formed are difficult to recover and purify.
- Bunyagidj,Piotrowska,Aldridge
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p. 344 - 346
(2007/10/02)
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