cas 76205-19-1, 1-(4-CHLOROPHENYL)-3-HYDROXY-1H-PYRAZOLE

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Environment-friendly synthesis process of 1-(4-chlorphenyl)-3-pyrazole alcohol
;The invention discloses a green synthesis process of 1-(4-chlorphenyl)-3-pyrazole alcohol, and the process comprises the following steps: adding p-chloroaniline, absolute ethyl alcohol and sodium ethoxide serving as raw materials into a four-neck flask with a mechanical stirrer and a reflux condensing tube box thermometer, performing stirring until the raw materials are dissolved, slowly adding p-chlorophenylhydrazine hydrochloride, and slowly dropwise adding ethyl acrylate after the reaction is finished, recovering absolute ethyl alcohol through reduced pressure distillation, adding water into residues, uniformly stirring, adjusting the pH value to 2 with hydrochloric acid, separating out solids, performing washing with water, performing drying to obtain a product, adding water into residues obtained after ethanol is recovered through reduced pressure distillation in synthesis of 1-(4-chlorphenyl)-3-pyrazol, performing heating, slowly dropwise adding hydrogen peroxide, and performingcooling to room temperature after the reaction is finished; and adjusting precipitated solids with hydrochloric acid, performing washing with water and performing drying for 10 minutes to obtain theproduct. According to the present invention, the 1-(4-chlorphenyl)-3-pyrazole alcohol synthesis method is reasonable, and the synthesized 1-(4-chlorphenyl)-3-pyrazole alcohol has high efficiency.
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Paragraph 0033-0048

(2021/03/13)

Method for preparing 1-(4-chlorphenyl)-pyrazolidine-3-one
The invention relates to the field of bactericide synthesis, and discloses a method for preparing 1-(4-chlorphenyl)-pyrazolidine-3-one. The method comprises the following steps: 1) reacting parachloroaniline with acrylic acid to obtain an addition reactio
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(2021/02/10)

Preparation method of pyraclostrobin intermediate
The invention discloses a preparation method of pyraclostrobin intermediate 3 - hydroxyl - 1H - pyrazole and 1 - (4 - chlorophenyl) -3 - pyrazol, which comprises: synthesizing 3 - hydroxyl - 1H - pyrazole -4 - carboxylic acid ethyl ester by cyclization re
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Paragraph 0032; 0064-0065

(2021/09/15)

Preparation method of 1-(4-chlorphenyl)-3-pyrazolol
The invention belongs to the field of chemical synthesis of medicines, and in particularly relates to a preparation method of 1-(4-chlorphenyl)-3-pyrazolol. The method comprises the steps: in the presence of a copper catalyst, an alkali and an organic solvent, carrying out Ullmann coupling reaction on 3-hydroxy-1H-pyrazole-4-carboxylic acid ethyl ester and 4-bromochlorobenzene or 4-iodo chlorobenzene, and carrying out acidic hydrolysis decarboxylation on the obtained 1-(4-chlorphenyl)-3-pyrazole-4-carboxylic acid ethyl ester to obtain 1-(4-chlorphenyl)-3-pyrazolol. According to the method disclosed by the invention, the use of a raw material p-chlorophenylhydrazine which is serious in environmental pollution and high in toxicity is avoided, the method is cleaner and more environment-friendly, the synthetic route is shortened, the yield is increased, and the production cost is greatly reduced.
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Paragraph 0033-0096

(2020/05/05)

Synthesis method and application of 1-(4-chlorphenyl)-3-pyrazole alcohol
The invention belongs to the field of chemical drug synthesis, and discloses a synthesis method and application of 1-(4-chlorphenyl)-3-pyrazole alcohol. The synthesis method comprises the steps: preparing 2-(chloromethyl)-1,3-dioxolane from ethylene glycol and chloroacetaldehyde in the presence of a catalyst, reacting with cyanide to prepare 3-oxopropionamide, and carrying out cyclization reactionon p-chlorophenylhydrazine hydrochloride and 3-oxopropionamide to obtain the cyclization product 1-(4-chlorphenyl)-3-pyrazol with purity higher than 96%. The synthesized 1-(4-chlorphenyl)-3-pyrazolealcohol can be used as an important intermediate in the synthesis process of the bactericide pyraclostrobin.
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Paragraph 0020-0027

(2020/05/01)

Preparation method for high-purity pyraclostrobin
The invention relates to the technical field of compound synthesis, in particular to a preparation method for high-purity pyraclostrobin. The pyraclostrobin is synthesized from p-chloroaniline and o-nitrosotoluene as initial raw materials through the steps of diazotizing, cyclizing, oxidizing, bromizing, condensating, reducing, acylating, methylating and the like. According to the preparation method, the problem that the purity of the pyraclostrobin in the prior art is low is solved; and the preparation method for the pyraclostrobin has the advantages of high yield, high purity and high material utilization rate.
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Paragraph 0029; 0054; 0065-0066

(2019/04/02)

Design, Synthesis, and Structure-Activity Relationship of New Arylpyrazole Pyrimidine Ether Derivatives as Fungicides
To explore a novel fungicide effectively against cucumber downy mildew (CDM), a series of new arylpyrazole containing pyrimidine ether derivatives were designed and synthesized by employing the intermediate derivatization method (IDM). The structures of synthesized compounds were identified by 1H NMR, 13C NMR, elemental analyses, MS, and X-ray diffraction. Bioassays demonstrated that some of the title compounds exhibited excellent fungicidal activities against CDM. Especially, compound 7 (EC50 = 1.22 mg/L) displayed significantly higher bioactivity than that of commercial fungicides diflumetorim and flumorph and nearly equal effect to that of cyazofamid. The relationship between the structure and fungicidal activity of the synthesized compounds was discussed as well. The study showed that compound 7 was a promising fungicide candidate for further development.
Zhang, Pengfei,Guan, Aiying,Xia, Xiaoli,Sun, Xufeng,Wei, Siyuan,Yang, Jinlong,Wang, Junfeng,Li, Zhinian,Lan, Jie,Liu, Changling
(2019/10/14)

Design, synthesis, and fungicidal activity of novel 1,3,4-oxadiazole derivatives
Employing the intermediate derivatization method (IDM), twenty novel 1,3,4-oxadiazole derivatives containing arylpyrazoloxyl moiety were designed and synthesized. The structures of the title compounds were identified by 1H NMR, 13C NMR, MS and elemental analyses, compound 4 was further identified by single-crystal X-ray diffraction. Antifungal activities against rice sheath blight (RSB) and sorghum anthracnose (SA) were evaluated by the mycelium linear growth rate method. Compounds 4, 16 and 20 displayed significant activities against RSB (EC50 = 0.88 mg/L, 0.91 mg/L and 0.85 mg/L, respectively), higher than the reference tebuconazole; While compound 3 exhibited higher activity against SA (EC50 = 1.03 mg/L), equal to commercial pyraclostrobin (EC50 = 1.06 mg/L). The study showed that compound 20 is a promising fungicide for further development.
Yu, Fuqiang,Guan, Aiying,Li, Mengru,Hu, Lan,Li, Xiaowu
p. 915 - 918
(2018/04/05)

Preparation method of 1-(4-chlorophenyl)-3-hydroxy-1-h-pyrazole
The invention discloses a preparation method for 1-(4-chlorophenyl)-3-hydroxy-1-h-pyrazole. Hydrazine hydrate and acrylic ester are taken as raw materials to synthesize pyrazol-3-ketone, the pyrazol-3-ketone is oxidized into hydroxypyrazole, and finally,
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Page/Page column 5-11

(2018/11/03)

A novel one-pot approach to oxidative aromatization and bromination of pyrazolidin-3-one with HBr-H2O2 system
An efficient and green one-pot method for the oxidative aromatization and bromination of pyrazolidin-3-ones under mild conditions with a HBr-H2O2 system was developed. A mechanism was proposed.
Yang, Shanguang,Liu, Jingjing,Jin, Zhudan,Tian, Wei,Sun, Hao,Wang, Mingliang
p. 165 - 169
(2018/05/26)

METHOD FOR PRODUCING PYRAZOLE COMPOUND
A method for producing a pyrazole compound represented by formula (1): (wherein R1 represents an optionally substituted C1-12 alkyl group, an optionally substituted C3-12 cycloalkyl group, an optionally substituted C6-16 aryl group, or an optionally substituted pyridyl group, R2 and R3 each independently represent a hydrogen atom, a halogen atom, a C1-3 alkyl group, or a C1-3 haloalkyl group), said method including a step in which a pyrazolidine compound represented by formula (2): (wherein R1, R2, and R3 are as defined above) is reacted with a nitrite in the presence of an acid, allows a pyrazole compound to be produced industrially.
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Paragraph 0037; 0038; 0039; 0040; 0042; 0044; 0045

(2017/01/26)

A process for synthesizing pyraclostrobin
The invention concretely relates to a synthetic technology for pyraclostrobin. The synthetic technology comprises: firstly performing cyclization to obtain 1-(4-chlorophenyl)-pyrazol-3-one, oxidizing the pyrazol ring under the effect of an oxidant to generate 1-(4-chlorophenyl)-3-hydroxypyrazole, then using 2-nitrobenzyl bromide to performing etherification to generate 1-(4-chlorophenyl)-3-[2-(nitrophenyl)methoxy]-1H-pyrazole, then using a reducing agent to perform nitro reducing, so as to generate N-hydroxyl-2-[N'-(4-chlorophenyl)pyrazol-3'-yloxymethyl]aniline, then using ClCO2CH3 to perform N-acylation reaction to generate methyl N-hydroxyl-N-2-{[N'-(4-chlorophenyl)pyrazol-3'-yloxymethyl]phenyl}formate, and finally performing hydroxyl methylation under an alkaline condition to generate pyraclostrobin. The technology enables all operations in the pyraclostrobin preparation process to be relatively controllable, helps to improve the stability of the preparation process and improve the product yield, successfully employs low-cost reagents and substantially reduces production cost, and also the employed reagents are relatively small in toxicity, is relatively beneficial for environment protection, and has no corrosivity on plastic pipes, so that the production safety is improved.
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(2017/03/08)

Method for synthesizing pyraclostrobin intermediate
The invention discloses a method for synthesizing a pyraclostrobin intermediate. The synthetic method comprises the following steps: preparing an intermediate 1-(4-chlorophenyl)-3-hydroxy-1-h-pyrazole from 4-chlorophenylhydrazine hydrochloride prepared with p-bromochlorobenzene and hydrazine hydrate as reaction raw materials; reacting o-nitrotoluene with chlorine in the presence of a catalyst so as to prepare o-nitrobenzyl chloride; and subjecting 1-(4-chlorophenyl)-3-hydroxy-1-h-pyrazole and o-nitrobenzyl chloride to an etherification reaction so as to obtain the pyraclostrobin intermediate, i.e., an etherification product 2[(N-4-chlorophenyl)-3-pyrazolyl-oxymethyl]nitrobenzene. The synthetic method provided by the invention can greatly reduce the amount of waste water produced in the synthesis process of 4-chlorophenylhydrazine hydrochloride; with 4-chlorophenylhydrazine hydrochloride as a raw material, the produced intermediate 1-(4-chlorophenyl)-3-hydroxy-1-h-pyrazole has HPLC content of no less than 98% and yield of no less than 90%; since chlorine is used for replacing bromine or hydrobromic acid to prepare o-nitrobenzyl bromide, production cost and environmental protection burden are controlled; and the etherification product with a content of no less than 98% and yield of no less than 90% is obtained.
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Paragraph 0090; 0099

(2017/01/17)

PROCESS FOR PREPARING 1-(4-CHLOROPHENYL)-3-[(2-NITROPHENYL)METHOXY]-1H-PYRAZOLE
A process for preparing 1-(4-chlorophenyl)-3-[(2-nitrophenyl)methoxy]-1H- pyrazole of formula (I) comprising: dehydrogenation of 1-(4-chlorophenyl)-pyrazolidin- 3-one of formula (II) to give 1-(4-chlorophenyl)-3-hydroxy-1H-pyrazole of formula (III) and/or a salt thereof in the presence of a solvent comprising at least one polar aprotic solvent and subsequent reaction of the resulting solution of formula (III) and/or salt thereof with the compound of formula (IV) wherein the reaction is carried out in the solvent used in the dehydrogenation step and wherein the compound of formula (III) and/or salt thereof is not isolated prior to its reaction with the compound of formula (IV).
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Page/Page column 18

(2016/11/07)

A 1-(4-chlorophenyl)-3- the pyrazole is mellow method for the preparation of
The invention provides a preparation method of 1-(4-chlorophenyl)-3-hydroxypyrazole. P-chlorophenylhydrazine hydrochloride and acrylics are taken as raw materials and subjected to cyclization reaction and oxidation reaction with a one-pot method, so that 1-(4-chlorophenyl)-3-hydroxypyrazole is obtained. According to the method, 'one-pot method' reaction is realized, loss of transformed materials is avoided, the reaction period is shortened, the labor amount is reduced, the product quality is good, the yield is high, discharge of three wastes is reduced, the requirement of the green chemical technology is met, and the method has a good industrial application value.
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Paragraph 0007; 0030; 0031

(2016/11/24)

Method for synthesizing pyraclostrobin intermediate 1-(4-chlorophenyl)-3-hydroxy-1-h-pyrazole
The invention discloses a method for synthesizing a pyraclostrobin intermediate 1-(4-chlorophenyl)-3-hydroxy-1-h-pyrazole. The method comprises the steps that p-bromochlorobenzene and hydrazine hydrate are used as reaction raw materials, a phase transfer catalyst, a solvent and a catalyst are added for a reaction, and p-chlorobenzene hydrazine hydrochloride is prepared; the p-chlorobenzene hydrazine hydrochloride reacts with alkali, sodium alkoxide and acrylate, and a toluene solution of an intermediate pyrazolone is prepared in the presence of toluene; toluene in the toluene solution is removed, alkali and hydrogen peroxide are added for oxidization, and the 1-(4-chlorophenyl)-3-hydroxy-1-h-pyrazole solution is prepared. According to the synthesizing method, p-bromochlorobenzene and hydrazine hydrate are reacted for preparing the p-chlorobenzene hydrazine hydrochloride, so that the amount of wastewater produced in the synthesis process can be greatly reduced, usage of sulfite reducing agent and a large amount of acid is avoided, hazardous substance is prevented from being produced in the whole technological process, environment-friendly production is achieved, the HPLC content of 1-(4-chlorophenyl)-3-hydroxy-1-h-pyrazole is larger than or equal to 98%, and the yield is larger than or equal to 90%.
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Paragraph 0071; 0074; 0077-0078; 0083

(2018/02/04)

Tetrazolinone compound and application for same
Provided is a tetrazolinone compound given by formula (1) (wherein E represents the following group E16 or the like; Y represents -O-CH2- or the like; Q represents the following group Q46 or the like; R8 represents a C1-C6 alkyl group; R3, R30, and R31 may be the same or different, and represent hydrogen atoms or the like; A represents a C6-C16 aryl group or the like, optionally having one or more atoms or groups selected from the group P1; R5 represents a C1-C3 alkyl group; and X represents an oxygen or sulfur atom), and having exceptional efficacy in controlling harmful organisms.
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Paragraph 0671; 0672; 0673; 0674; 0675

(2016/10/08)

Preparation method of 1-(4-chlorophenyl)-3-pyrazole alcohol
The invention relates to a preparation method of 1-(4-chlorphenyl)-3-pyrazole alcohol and belongs to the technical field of pesticide intermediates. The preparation method includes the steps: adding an acidic solvent into a device, adding 1-(4-chlorophenyl)pyrazolidine-3-one and ferric trichloride while stirring, and heating until complete dissolving; feeding air for reaction, depressurizing to remove most solvent after reaction is finished; adding water, stirring, and separating massive products out; using a sodium hydroxide solution to adjust pH value, continuing to stir for 0.5 h, and filtering to obtain 1-(4-chlorophenyl)-3-pyrazole alcohol. The preparation method has the advantages that the acidic solvent is low in price and easy to acquire, and the preparation method is uniform in reaction, low in desolventizing energy consumption, high in yield, low in production cost and suitable for industrial production.
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Paragraph 0010; 0011

(2016/12/22)

Synthesis, fungicidal activity, structure-activity relationship and density functional theory studies of novel oxime ether derivatives containing 1-aryl-3-oxypyrazoles
A series of 16 oxime ether derivatives containing 1-aryl-3-oxypyrazoles were synthesised, and the structure of one of them, (E)-methyl 2-(2-({(1-(4-chlorophenyl)-1H-pyrazol-3-yl)-oxy}methyl)phenyl)-2-(methoxyimino)acetate was determined by X-ray diffraction crystallography. Preliminary bioassays indicated that some of these compounds exhibited very good fungicidal activities against Rhizoctonia solani, especially the ester 2-(2-({(1-(4-chlorophenyl)-1H-pyrazol-3-yl)-oxy}methyl)phenyl)-2-(methoxyimino)acetate, which displayed greater activity than control compound pyraclostrobin at a dosage of 0.1 μg mL-1. The relationship between structure and fungicidal activity was discussed. Density functional theory studies of the 3-methyl heterocyclic ester and the 4-chorophenyl heterocyclic N-methylamide were carried out and the results discussed in terms of the wide difference in fungicidal activity shown by each compound.
Lv, Kunzhi,Liu, Yuanyuan,Li, Yi,Xu, Guanghui,Pan, Xuechun,Li, Fangshi,Chen, Kai,Huang, Bin,Yang, Yaping
p. 594 - 600
(2015/11/27)

Synthesis and fungicidal activity of novel chloro-containing 1-Aryl-3-oxypyrazoles with an oximino ester or oximino amide moiety
Six novel chloro-containing 1-aryl-3-oxypyrazoles TMa-TMf with an oximino ester or an oximino amide moiety were prepared by the reaction of 1-aryl-1H-pyrazol-3-ols with benzyl bromide. Their structures were characterized by 1H-NMR, 13C-NMR, IR, MS, and elemental analysis. A preliminary in vitro bioassay indicated that compounds TMa, TMe and TMf displayed excellent fungicidal activity against Rhizoctonia solani and could be used as potential lead compounds for further development of novel fungicides.
Liu, Yuanyuan,Li, Yi,Chen, Nanqing,Lv, Kunzhi,Zhou, Chao,Xiong, Xiaohui,Li, Fangshi
p. 8140 - 8150
(2014/07/08)

TETRAZOLINONE COMPOUNDS AND ITS USE AS PESTICIDES
The present invention provides a compound having an excellent efficacy for controlling pests. A tetrazolinone compound of a formula (1): [wherein R1 represents an C6-C16 aryl group, an C1-C12 alkyl group, or a C3-C12 cycloalkyl group, etc., which each optionally be substituted; R2, R3, R4 and R5 represent independently of each other a hydrogen atom, a halogen atom or an C1-C3 alkyl group, etc.; R6 represents an C1-C6 alkyl group, a C3-C6 cycloalkyl group, a halogen atom, a C1-C6 haloalkyl group, an C2-C6 alkenyl group, an C1-C6 alkoxy group, or a C1-C6 haloalkoxy group, etc.; R7, R8 and R9 represent independently of each other a hydrogen atom, a halogen atom, or an C1-C4 alkyl group, etc.; X represents an oxygen atom or a sulfur atom; and R10 represents an C1-C6 alkyl group, etc.] shows an excellent controlling efficacy on pests.
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Page/Page column 954

(2013/11/18)

Synthesis and biological evaluation of the 1-arylpyrazole class of σ1 receptor antagonists: Identification of 4-{2-[5-methyl-1- (naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862)
The synthesis and pharmacological activity of a new series of 1-arylpyrazoles as potent σ1 receptor (σ1R) antagonists are reported. The new compounds were evaluated in vitro in human σ1R and guinea pig σ2 receptor (σ2R) binding assays. The nature of the pyrazole substituents was crucial for activity, and a basic amine was shown to be necessary, in accordance with known receptor pharmacophores. A wide variety of amines and spacer lengths between the amino and pyrazole groups were tolerated, but only the ethylenoxy spacer and small cyclic amines provided compounds with sufficient selectivity for σ1R vs σ2R. The most selective compounds were further profiled, and compound 28, 4-{2-[5-methyl-1- (naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862), which showed high activity in the mouse capsaicin model of neurogenic pain, emerged as the most interesting candidate. In addition, compound 28 exerted dose-dependent antinociceptive effects in several neuropathic pain models. This, together with its good physicochemical, safety, and ADME properties, led compound 28 to be selected as clinical candidate.
Diaz, Jose Luis,Cuberes, Rosa,Berrocal, Joana,Contijoch, Montserrat,Christmann, Ute,Fernandez, Ariadna,Port, Adriana,Holenz, Joerg,Buschmann, Helmut,Serafini, Maria Teresa,Burgueno, Javier,Zamanillo, Daniel,Merlos, Manuel,Vela, Jose Miguel,Almansa, Carmen,Laggner, Christian
p. 8211 - 8224,14
(2020/09/15)

Synthesis of site-heterologous haptens for high-affinity anti-pyraclostrobin antibody generation
The design and synthesis of functional chemical derivatives of small organic molecules is usually a key step for the intricate production of a variety of bioconjugates. In this respect, the derivatization site at which the spacer arm is introduced in immunizing conjugates constitutes a highly critical parameter for the generation of high-affinity and selective antibodies. However, due to the usual complexity of the required synthetic procedures, the appropriate comparison of alternative tethering positions has often been neglected. In the present study, meticulous strategies were followed to prepare synthetic derivatives of pyraclostrobin with the same linkers located at diverse rationally-chosen sites. Activity appraisal of antibodies and bioconjugates was carried out by bidimensional competitive direct and indirect immunoassays, and a superior performance of two of the three synthesized haptens was found. Finally, a detailed analysis of the conformations of the target molecule and the synthesized haptens in aqueous solution was done using computer assisted molecular modeling techniques. This study suggested that the lower titers and affinities of one set of antibodies are most probably due to conformational effects of the spacer arm in the immunizing bioconjugate. The Royal Society of Chemistry 2011.
Mercader, Josep V.,Agullo, Consuelo,Abad-Somovilla, Antonio,Abad-Fuentes, Antonio
p. 1443 - 1453
(2011/04/22)

DMF-catalyzed direct and regioselective C-H functionalization: Electrophilic/nucleophilic 4-halogenation of 3-oxypyrazoles
A novel, straightforward, and highly regioselective 4-chlorination of 3-oxypyrazole derivatives in boiling thionyl chloride (SOCl2) in the presence of catalytic N,N-dimethylformamide (DMF) has been developed. This reaction likely proceeds through a DMF-catalyzed electrophilic/nucleophilic chlorination mechanism and involves electrophilic attack by SOCl2 and nucleophilic substitution by Cl- as the key steps. Based on this mechanism, the corresponding 4-bromination and 4-iodination of 3-oxypyrazoles have also been achieved in good yield by adding Br- and I -, respectively, to the reaction system. This halogenation method enables quick access to many original 4-halo-3-oxypyrazole series. A novel DMF-catalyzed electrophilic/nucleophilic 4-halogenation of 3-oxypyrazole derivatives has been developed. This halogenation procedure provides quick access to many novel 4-halo-3-oxypyrazole series.
Liu, Yuanyuan,He, Guangke,Chen, Kai,Jin, Yin,Li, Yufeng,Zhu, Hongjun
p. 5323 - 5330
(2011/11/13)

Synthesis, crystal structure and fungicidal activities of new type oxazolidinone-based strobilurin analogues
A series of oxazolidinone-based strobilurin analogues were efficiently synthesized by the reaction of 3-(2-bromomethylphenyl) oxazolidin-2-one with 1-substituted phenyl-2H-pyrazolin-3-one. Their structures were confirmed and characterized by 1H-NMR, 13C-NMR, elemental analysis, and mass spectroscopy. In addition, the crystal structure of the target compound 3-(2-((1-phenyl-2H-pyrazol-3-yloxy)methyl)phenyl) oxazolidin-2-one was determined by single crystal X-ray diffraction. The bioassay results of these compounds indicated that some of the oxazolidin-2-one derivatives containing N-substituted phenyl 2H-pyrazol ring exhibited potential in vivo fungicidal activities against M. grisea at the dosage of 1 g L-1.
Li, Yuhao,Liu, Rui,Yan, Zhangwei,Zhang, Xiangning,Zhu, Hongjun
p. 3341 - 3347
(2012/05/05)

Method for producing N-substituted 3-hydroxypyrazoles
PCT No. PCT/EP97/06780 Sec. 371 Date Jun. 14, 1999 Sec. 102(e) Date Jun. 14, 1999 PCT Filed Dec. 4, 1997 PCT Pub. No. WO98/27062 PCT Pub. Date Jun. 25, 1998A process is described for preparing N-substituted 3-hydroxypyrazoles of the formula I where R1 is unsubstituted or substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl or heteroaryl and R2, R3 are hydrogen, cyano, halogen and unsubstituted or substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl or heteroaryl, by oxidizing a corresponding pyrazolidin-3-one.
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(2008/06/13)

Methyl α-phenylbutenoates
Methyl α-phenylbutenoates of the formula I STR1 where -- is a single or double bond and the index and the substituents have the following meanings: n is 0, 1, 2, 3 or 4; R1 is nitro, cyano, halogen, alkyl, haloalkyl or alkoxy; R2 is
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(2008/06/13)