76205-19-1

Usage

Uses

Used in Pharmaceutical Industry:
1-(4-CHLOROPHENYL)-3-HYDROXY-1H-PYRAZOLE is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a key component in the development of new drugs with specific therapeutic properties.
Used in Synthesis of Antifungal Agents:
In the field of antifungal drug development, 1-(4-CHLOROPHENYL)-3-HYDROXY-1H-PYRAZOLE is used as a starting material for the synthesis of oxazolidinon-based strobilurin analogues. These analogues are known for their potent antifungal activity against a wide range of fungal pathogens, making them valuable in the treatment of various fungal infections.
Used in Synthesis of Haptens:
1-(4-CHLOROPHENYL)-3-HYDROXY-1H-PYRAZOLE is also utilized in the preparation of heterologous haptens, which are essential for the synthesis of high-affinity anti-pyraclostrobin antibodies. These antibodies have potential applications in research, diagnostics, and therapeutics, particularly in the detection and treatment of pyraclostrobin-related conditions.

Flammability and Explosibility

Notclassified

Upstream product

• 6119-12-6 1-(4-chlorophenyl)-3-pyrazolidinone 
• 71-48-7 cobalt(II) acetate 
• 106-47-8 4-chloro-aniline 
• 1073-69-4 N-4-chlorophenylhydrazine 
• 623-47-2 propynoic acid ethyl ester 
• 140-88-5 ethyl acrylate 
• 106-39-8 bromochlorobenzene 
• 292638-85-8 acrylic acid methyl ester 
• 137-45-1 3-hydroxy pyrazole 
• 1073-70-7 4-chlorophenylhydrazine hydrochloride 
• 106-46-7 para-dichlorobenzene 
• 383-11-9 4-(trifluoromethylsulfonyl)chlorobenzene 
• 637-87-6 1-Chloro-4-iodobenzene 
• 7251-53-8 3-hydroxypyrazole-4-carboxylic acid ethyl ester 

Downstream Products

• 235441-18-6 methyl [2-(1-(4-chlorophenyl)-3-pyrazolyloxy)pyridin-3-yl]glyoxylate 
• 1257338-98-9 3-(2-((1-(4-chlorophenyl)-2H-pyrazol-3-yloxy)methyl)phenyl)oxazolidin-2-one 
• 1392758-90-5 C₁₅H₁₈ClN₃O₂ 
• 1445342-06-2 1-((1-(4-chlorophenyl)-1H-pyrazol-3-yl)oxy)propan-2-one 
• 1445341-96-7 1-(4-chloro-phenyl)-3-((Z)-3-tributylstannanyl-but-2-enyloxy)-1H-pyrazole 
• 1445333-46-9 (3Z,2E)-5-{[1-(4-chlorophenyl)pyrazol-3-yl]oxy}-2-methoxyimino-N,4-dimethylpent-3-enamide 

Relevant academic research and scientific papers

Preparation method of pyraclostrobin intermediate

The invention discloses a preparation method of pyraclostrobin intermediate 3 - hydroxyl - 1H - pyrazole and 1 - (4 - chlorophenyl) -3 - pyrazol, which comprises: synthesizing 3 - hydroxyl - 1H - pyrazole -4 - carboxylic acid ethyl ester by cyclization re

Environment-friendly synthesis process of 1-(4-chlorphenyl)-3-pyrazole alcohol

;The invention discloses a green synthesis process of 1-(4-chlorphenyl)-3-pyrazole alcohol, and the process comprises the following steps: adding p-chloroaniline, absolute ethyl alcohol and sodium ethoxide serving as raw materials into a four-neck flask with a mechanical stirrer and a reflux condensing tube box thermometer, performing stirring until the raw materials are dissolved, slowly adding p-chlorophenylhydrazine hydrochloride, and slowly dropwise adding ethyl acrylate after the reaction is finished, recovering absolute ethyl alcohol through reduced pressure distillation, adding water into residues, uniformly stirring, adjusting the pH value to 2 with hydrochloric acid, separating out solids, performing washing with water, performing drying to obtain a product, adding water into residues obtained after ethanol is recovered through reduced pressure distillation in synthesis of 1-(4-chlorphenyl)-3-pyrazol, performing heating, slowly dropwise adding hydrogen peroxide, and performingcooling to room temperature after the reaction is finished; and adjusting precipitated solids with hydrochloric acid, performing washing with water and performing drying for 10 minutes to obtain theproduct. According to the present invention, the 1-(4-chlorphenyl)-3-pyrazole alcohol synthesis method is reasonable, and the synthesized 1-(4-chlorphenyl)-3-pyrazole alcohol has high efficiency.

Method for preparing 1-(4-chlorphenyl)-pyrazolidine-3-one

The invention relates to the field of bactericide synthesis, and discloses a method for preparing 1-(4-chlorphenyl)-pyrazolidine-3-one. The method comprises the following steps: 1) reacting parachloroaniline with acrylic acid to obtain an addition reactio

Preparation method of 1-(4-chlorphenyl)-3-pyrazolol

The invention belongs to the field of chemical synthesis of medicines, and in particularly relates to a preparation method of 1-(4-chlorphenyl)-3-pyrazolol. The method comprises the steps: in the presence of a copper catalyst, an alkali and an organic solvent, carrying out Ullmann coupling reaction on 3-hydroxy-1H-pyrazole-4-carboxylic acid ethyl ester and 4-bromochlorobenzene or 4-iodo chlorobenzene, and carrying out acidic hydrolysis decarboxylation on the obtained 1-(4-chlorphenyl)-3-pyrazole-4-carboxylic acid ethyl ester to obtain 1-(4-chlorphenyl)-3-pyrazolol. According to the method disclosed by the invention, the use of a raw material p-chlorophenylhydrazine which is serious in environmental pollution and high in toxicity is avoided, the method is cleaner and more environment-friendly, the synthetic route is shortened, the yield is increased, and the production cost is greatly reduced.

Synthesis method and application of 1-(4-chlorphenyl)-3-pyrazole alcohol

The invention belongs to the field of chemical drug synthesis, and discloses a synthesis method and application of 1-(4-chlorphenyl)-3-pyrazole alcohol. The synthesis method comprises the steps: preparing 2-(chloromethyl)-1,3-dioxolane from ethylene glycol and chloroacetaldehyde in the presence of a catalyst, reacting with cyanide to prepare 3-oxopropionamide, and carrying out cyclization reactionon p-chlorophenylhydrazine hydrochloride and 3-oxopropionamide to obtain the cyclization product 1-(4-chlorphenyl)-3-pyrazol with purity higher than 96%. The synthesized 1-(4-chlorphenyl)-3-pyrazolealcohol can be used as an important intermediate in the synthesis process of the bactericide pyraclostrobin.

Preparation method for high-purity pyraclostrobin

The invention relates to the technical field of compound synthesis, in particular to a preparation method for high-purity pyraclostrobin. The pyraclostrobin is synthesized from p-chloroaniline and o-nitrosotoluene as initial raw materials through the steps of diazotizing, cyclizing, oxidizing, bromizing, condensating, reducing, acylating, methylating and the like. According to the preparation method, the problem that the purity of the pyraclostrobin in the prior art is low is solved; and the preparation method for the pyraclostrobin has the advantages of high yield, high purity and high material utilization rate.

Design, Synthesis, and Structure-Activity Relationship of New Arylpyrazole Pyrimidine Ether Derivatives as Fungicides

To explore a novel fungicide effectively against cucumber downy mildew (CDM), a series of new arylpyrazole containing pyrimidine ether derivatives were designed and synthesized by employing the intermediate derivatization method (IDM). The structures of synthesized compounds were identified by 1H NMR, 13C NMR, elemental analyses, MS, and X-ray diffraction. Bioassays demonstrated that some of the title compounds exhibited excellent fungicidal activities against CDM. Especially, compound 7 (EC50 = 1.22 mg/L) displayed significantly higher bioactivity than that of commercial fungicides diflumetorim and flumorph and nearly equal effect to that of cyazofamid. The relationship between the structure and fungicidal activity of the synthesized compounds was discussed as well. The study showed that compound 7 was a promising fungicide candidate for further development.

A novel one-pot approach to oxidative aromatization and bromination of pyrazolidin-3-one with HBr-H2O2 system

An efficient and green one-pot method for the oxidative aromatization and bromination of pyrazolidin-3-ones under mild conditions with a HBr-H2O2 system was developed. A mechanism was proposed.