76205-19-1Relevant articles and documents
Environment-friendly synthesis process of 1-(4-chlorphenyl)-3-pyrazole alcohol
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Paragraph 0033-0048, (2021/03/13)
;The invention discloses a green synthesis process of 1-(4-chlorphenyl)-3-pyrazole alcohol, and the process comprises the following steps: adding p-chloroaniline, absolute ethyl alcohol and sodium ethoxide serving as raw materials into a four-neck flask with a mechanical stirrer and a reflux condensing tube box thermometer, performing stirring until the raw materials are dissolved, slowly adding p-chlorophenylhydrazine hydrochloride, and slowly dropwise adding ethyl acrylate after the reaction is finished, recovering absolute ethyl alcohol through reduced pressure distillation, adding water into residues, uniformly stirring, adjusting the pH value to 2 with hydrochloric acid, separating out solids, performing washing with water, performing drying to obtain a product, adding water into residues obtained after ethanol is recovered through reduced pressure distillation in synthesis of 1-(4-chlorphenyl)-3-pyrazol, performing heating, slowly dropwise adding hydrogen peroxide, and performingcooling to room temperature after the reaction is finished; and adjusting precipitated solids with hydrochloric acid, performing washing with water and performing drying for 10 minutes to obtain theproduct. According to the present invention, the 1-(4-chlorphenyl)-3-pyrazole alcohol synthesis method is reasonable, and the synthesized 1-(4-chlorphenyl)-3-pyrazole alcohol has high efficiency.
Preparation method of pyraclostrobin intermediate
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Paragraph 0032; 0064-0065, (2021/09/15)
The invention discloses a preparation method of pyraclostrobin intermediate 3 - hydroxyl - 1H - pyrazole and 1 - (4 - chlorophenyl) -3 - pyrazol, which comprises: synthesizing 3 - hydroxyl - 1H - pyrazole -4 - carboxylic acid ethyl ester by cyclization re
Preparation method of 1-(4-chlorphenyl)-3-pyrazolol
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Paragraph 0033-0096, (2020/05/05)
The invention belongs to the field of chemical synthesis of medicines, and in particularly relates to a preparation method of 1-(4-chlorphenyl)-3-pyrazolol. The method comprises the steps: in the presence of a copper catalyst, an alkali and an organic solvent, carrying out Ullmann coupling reaction on 3-hydroxy-1H-pyrazole-4-carboxylic acid ethyl ester and 4-bromochlorobenzene or 4-iodo chlorobenzene, and carrying out acidic hydrolysis decarboxylation on the obtained 1-(4-chlorphenyl)-3-pyrazole-4-carboxylic acid ethyl ester to obtain 1-(4-chlorphenyl)-3-pyrazolol. According to the method disclosed by the invention, the use of a raw material p-chlorophenylhydrazine which is serious in environmental pollution and high in toxicity is avoided, the method is cleaner and more environment-friendly, the synthetic route is shortened, the yield is increased, and the production cost is greatly reduced.