Preparation method of nitrogen unsubstituted pyrazole and indazole boric acid
The invention discloses a method for preparing nitrogen unsubstituted pyrazole and indazole boric acid. Nitrogen unsubstituted halogenated pyrazole and a derivative thereof, or nitrogen unsubstitutedhalogenated indazole and a derivative of the nitrogen unsubstituted halogenated indazole react with triisopropylchlorosilane in an organic solvent to generate a triisopropylsilyl protected halogenatedpyrazole or halogenated indazole compound, then a lithium-bromine exchange reaction is carried out with n-butyl lithium, a borate is added to introduce boron atoms, and the nitrogen unsubstituted pyrazole or indazole boric acid is obtained in high yield after hydrolysis.
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Paragraph 0029-0031; 0034-0036
(2020/01/12)
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