76471-06-2

Basic information

• Product Name: 3-CHLORO-4-([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]OXY)ANILINE
• Synonyms: 3-CHLORO-4-([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]OXY)ANILINE;3-CHLORO-4-{[3-CHLORO-5-(TRIFLUOROMETHYL
• CAS NO: 76471-06-2
• Molecular Formula: C₁₂H₇Cl₂F₃N₂O
• Molecular Weight: 323.1
• Mol File: 76471-06-2.mol

Chemical Properties

• Melting Point: 90-92°C
• Boiling Point: 353.6 °C at 760 mmHg
• Flash Point: 167.7 °C
• Appearance: /
• Density: 1.517 g/cm³
• Vapor Pressure: 3.55E-05mmHg at 25°C
• Refractive Index: 1.569
• PKA: 2.87±0.10(Predicted)
• CAS DataBase Reference: 3-CHLORO-4-([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]OXY)ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-4-([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]OXY)ANILINE(76471-06-2)
• EPA Substance Registry System: 3-CHLORO-4-([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]OXY)ANILINE(76471-06-2)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 76471-06-2(Hazardous Substances Data)

Usage

Uses

Used in Residential Applications:
Bifenthrin is used as a residential insecticide for controlling and eliminating various household pests such as ants, spiders, and beetles. Its effectiveness in disrupting the insects' nervous systems ensures a rapid and efficient pest control solution.
Used in Industrial Applications:
In industrial settings, Bifenthrin serves as a crucial insecticide to protect facilities from pest infestations. It is particularly useful in areas where food is processed or stored, as it helps maintain cleanliness and prevent contamination by insects.
Used in Agricultural Applications:
Bifenthrin is employed in agriculture as a crop protectant, safeguarding plants from destructive insect pests. Its application helps to ensure healthy crop growth and yield, contributing to increased agricultural productivity.
Used in Aquatic Ecosystems Management:
Although Bifenthrin is toxic to fish and other aquatic organisms, it can be used with caution in aquatic ecosystems management to control specific pests that may threaten the balance of the ecosystem. Proper application and adherence to safety guidelines are imperative to minimize harm to non-target species.
Used in Bee and Beneficial Insect Protection:
Bifenthrin can be applied in a manner that minimizes harm to bees and other beneficial insects. By following label instructions and safety precautions, it is possible to protect these important pollinators while still effectively controlling pest populations.

InChI:InChI=1/C12H7Cl2F3N2O/c13-8-4-7(18)1-2-10(8)20-11-9(14)3-6(5-19-11)12(15,16)17/h1-5H,18H2

Upstream product

• 3964-52-1 2-chloro 4-aminophenol 
• 69045-84-7 2,3-dichloro-5-trifluoromethylpyridine 
• 76041-71-9 3-chloro-5-(trifluoromethyl)-2-hydroxypyridine 
• 350-30-1 3-chloro-4-fluoronitrobenzene 

Downstream Products

• 71422-62-3 1-(2-Chloro-benzoyl)-3-[3-chloro-4-(3-chloro-5-trifluoromethyl-pyridin-2-yloxy)-phenyl]-urea 

Relevant articles and documents

Synthesis, biochemical evaluation and computational simulations of new cytochrome bc1 complex inhibitors based on N-(4-aryloxyphenyl) phthalimides

The cytochrome bc1 complex (the bc1 complex or complex III) is an attractive target for the discovery of numerous pharmaceuticals and pesticides. In order to identify new lead structures for this target, a new series of molecules, N-(4-aryloxyphenyl)phthalimides, were designed and synthesized in a straightforward manner. Our design strategy was to introduce a 4-aryloxyphenyl group, a fragment which exhibited promising bc1 complex-inhibiting properties, into the aryl group of the valuable N-arylphthalimide backbone. Afterward, the biochemical evaluation of the newly synthesized compounds was carried out, and the results implied that several compounds demonstrated good activities against succinate-cytochrome reductase (SCR, a mixture of mitochondrial complex II and the bc1 complex). Further studies confirmed that 3e′ a representative compound in this paper, was identified as an inhibitor of the bc1 complex. Furthermore, computational simulations were also performed to better understand binding of 3e′ to the enzyme complex, which indicated that 3e′ should bind to the Qo site of the bc1 complex. Consequently, we harbor the idea that this paper can provide a solid platform for synthesis and discovery of other bc1 complex inhibitors.

Synthesis and antitumor activities of novel benzoylphenylurea derivatives

Seventy novel benzoylphenylurea compounds were synthesized and their antitumor activities were examined in vivo against P388 leukemia. N-(2-Nitrobenzoyl)-N'-[4-(2-pyrimidinyloxy)phenyl]ureas showed the highest antitumor activities when dosed intraperitoneally or orally. Their structure-activity relationships were examined with particular focus on the position and the variety of substituent on each aryl ring.