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76041-71-9

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76041-71-9 Usage

Uses

3-Chloro-5-(trifluoromethyl)pyridin-2(3H)-one is a useful research chemical.

Chemical Properties

White to light yellow solid

Check Digit Verification of cas no

The CAS Registry Mumber 76041-71-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,6,0,4 and 1 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 76041-71:
(7*7)+(6*6)+(5*0)+(4*4)+(3*1)+(2*7)+(1*1)=119
119 % 10 = 9
So 76041-71-9 is a valid CAS Registry Number.
InChI:InChI=1/C6H4F3NS/c7-6(8,9)4-1-2-5(11)10-3-4/h1-3H,(H,10,11)

76041-71-9 Well-known Company Product Price

  • Brand
  • (Code)Product description
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  • Alfa Aesar

  • (H66286)  3-Chloro-2-hydroxy-5-(trifluoromethyl)pyridine, 95%   

  • 76041-71-9

  • 1g

  • 269.0CNY

  • Detail
  • Alfa Aesar

  • (H66286)  3-Chloro-2-hydroxy-5-(trifluoromethyl)pyridine, 95%   

  • 76041-71-9

  • 5g

  • 1075.0CNY

  • Detail
  • Aldrich

  • (390534)  3-Chloro-5-(trifluoromethyl)-2-pyridinol  98%

  • 76041-71-9

  • 390534-5G

  • 1,057.68CNY

  • Detail

76041-71-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-Chloro-2-Hydroxy-5-(Trifluoromethyl)Pyridine

1.2 Other means of identification

Product number -
Other names 3-chloro-5-(trifluoromethyl)-1H-pyridin-2-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:76041-71-9 SDS

76041-71-9Synthetic route

2-hydroxy-5-(trifluoromethyl)pyridine
33252-63-0

2-hydroxy-5-(trifluoromethyl)pyridine

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With N-chloro-succinimide In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide at 20℃; for 8h; Solvent;92%
2,3-dichloro-5-trifluoromethylpyridine
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With potassium hydroxide In tert-butyl alcohol for 1h; Heating;75.2%
2,3-dichloro-5-(trichloromethyl)pyridine
69045-83-6

2,3-dichloro-5-(trichloromethyl)pyridine

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 80.4 percent / antimony trifluoride / 0.17 h / Heating; Irradiation
2: 75.2 percent / potassium hydroxide / 2-methyl-propan-2-ol / 1 h / Heating
View Scheme
6-hydroxy-3-pyridinecarboxylic acid
5006-66-6

6-hydroxy-3-pyridinecarboxylic acid

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogen fluoride; sulfur tetrafluoride / 12 h / 100 °C / 1125.11 Torr / Autoclave
2: N-chloro-succinimide / N,N-dimethyl-formamide; 1-methyl-pyrrolidin-2-one / 8 h / 20 °C
View Scheme
chloroacetic acid ethyl ester
105-39-5

chloroacetic acid ethyl ester

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

ethyl 2-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)acetate

ethyl 2-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)acetate

Conditions
ConditionsYield
With potassium carbonate In acetonitrile Reflux;94%
tris(3-(diethoxymethyl)phenyl)bismuthine

tris(3-(diethoxymethyl)phenyl)bismuthine

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

3-chloro-1-(3-(diethoxymethyl)phenyl)-5-(trifluoromethyl)-2(1H)-pyridinone
1613033-18-3

3-chloro-1-(3-(diethoxymethyl)phenyl)-5-(trifluoromethyl)-2(1H)-pyridinone

Conditions
ConditionsYield
With pyridine; copper diacetate In dichloromethane at 50℃; for 16h;89%
3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

3-chloro-5-(trifluoromethyl)-2-pyridinyl tosylate
1174281-15-2

3-chloro-5-(trifluoromethyl)-2-pyridinyl tosylate

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 20℃; for 1h;84%
2-(chloromethyl)-5-(4-nitrophenyl)-1,3,4-oxadiazole
50677-30-0

2-(chloromethyl)-5-(4-nitrophenyl)-1,3,4-oxadiazole

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

2-(5-(trifluoromethyl)pyridiloxymethyl)-5-(4-nitrophenyl)-1,3,4-oxadiazole

2-(5-(trifluoromethyl)pyridiloxymethyl)-5-(4-nitrophenyl)-1,3,4-oxadiazole

Conditions
ConditionsYield
With tetrabutylammomium bromide; potassium carbonate In N,N-dimethyl-formamide at 90℃;78%
3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

2-(chloromethyl)-5-(4-fluorophenyl)-1,3,4-oxadiazole
350672-14-9

2-(chloromethyl)-5-(4-fluorophenyl)-1,3,4-oxadiazole

2-(5-(trifluoromethyl)pyridiloxymethyl)-5-(4-fluorophenyl)-1,3,4-oxadiazole

2-(5-(trifluoromethyl)pyridiloxymethyl)-5-(4-fluorophenyl)-1,3,4-oxadiazole

Conditions
ConditionsYield
With tetrabutylammomium bromide; potassium carbonate In N,N-dimethyl-formamide at 90℃;77%
3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

5-(2,4-dichloro-5-fluorophenyl)-2-(chloromethyl)-1,3,4-oxadiazole
497182-11-3

5-(2,4-dichloro-5-fluorophenyl)-2-(chloromethyl)-1,3,4-oxadiazole

2-(5-(trifluoromethyl)pyridiloxymethyl)-5-(2,4-dichloro-5-fluorophenyl)-1,3,4-oxadiazole

2-(5-(trifluoromethyl)pyridiloxymethyl)-5-(2,4-dichloro-5-fluorophenyl)-1,3,4-oxadiazole

Conditions
ConditionsYield
With tetrabutylammomium bromide; potassium carbonate In N,N-dimethyl-formamide at 90℃;75%
methyl (E)-3-methoxy-2-(2-chloromethylphenyl)acrylate
117428-51-0

methyl (E)-3-methoxy-2-(2-chloromethylphenyl)acrylate

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

methyl (E)-2-(2-(((3-chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)methyl)phenyl)-3-methoxyacrylate

methyl (E)-2-(2-(((3-chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)methyl)phenyl)-3-methoxyacrylate

Conditions
ConditionsYield
Stage #1: 3-chloro-5-(trifluoromethyl)-2-hydroxypyridine With potassium carbonate In N,N-dimethyl-formamide for 0.5h;
Stage #2: methyl (E)-3-methoxy-2-(2-chloromethylphenyl)acrylate In N,N-dimethyl-formamide at 80℃; for 3h;
74.8%
3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

2-chloromethyl-5-(4-ethyl-phenyl)-[1,3,4]oxadiazole
350672-18-3

2-chloromethyl-5-(4-ethyl-phenyl)-[1,3,4]oxadiazole

2-(5-(trifluoromethyl)pyridiloxymethyl)-5-(4-ethylphenyl)-1,3,4-oxadiazole

2-(5-(trifluoromethyl)pyridiloxymethyl)-5-(4-ethylphenyl)-1,3,4-oxadiazole

Conditions
ConditionsYield
With tetrabutylammomium bromide; potassium carbonate In N,N-dimethyl-formamide at 90℃;74%
{[2-(trifluoromethyl)benzoyl]amino}methyl acetate
895525-72-1

{[2-(trifluoromethyl)benzoyl]amino}methyl acetate

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

N-({[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}methyl)-2-(trifluoromethyl)benzamide

N-({[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}methyl)-2-(trifluoromethyl)benzamide

Conditions
ConditionsYield
With sodium hydroxide In tetrahydrofuran; water at 20℃; for 14h;74%
3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

methyl (E)-2-[2-(bromomethyl)phenyl]-2-(methoxyimino)acetate
133409-72-0

methyl (E)-2-[2-(bromomethyl)phenyl]-2-(methoxyimino)acetate

methyl (E)-2-(2-(((3-chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)methyl)phenyl)-2-(methoxyimino)acetate

methyl (E)-2-(2-(((3-chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)methyl)phenyl)-2-(methoxyimino)acetate

Conditions
ConditionsYield
Stage #1: 3-chloro-5-(trifluoromethyl)-2-hydroxypyridine With potassium carbonate In butanone for 0.5h;
Stage #2: methyl (E)-2-[2-(bromomethyl)phenyl]-2-(methoxyimino)acetate In butanone at 80℃; for 5h;
73.5%
2-(chloromethyl)-5-(4-methoxyphenyl)-1,3,4-oxadiazole
24023-71-0

2-(chloromethyl)-5-(4-methoxyphenyl)-1,3,4-oxadiazole

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

2-(5-(trifluoromethyl)pyridiloxymethyl)-5-(4-methoxyphenyl)-1,3,4-oxadiazole

2-(5-(trifluoromethyl)pyridiloxymethyl)-5-(4-methoxyphenyl)-1,3,4-oxadiazole

Conditions
ConditionsYield
With tetrabutylammomium bromide; potassium carbonate In N,N-dimethyl-formamide at 90℃;73%
3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

2-(chloromethyl)-5-phenyl-1,3,4-oxadiazole
33575-83-6

2-(chloromethyl)-5-phenyl-1,3,4-oxadiazole

2-(5-(trifluoromethyl)pyridiloxymethyl)-5-phenyl-1,3,4-oxadiazole

2-(5-(trifluoromethyl)pyridiloxymethyl)-5-phenyl-1,3,4-oxadiazole

Conditions
ConditionsYield
With tetrabutylammomium bromide; potassium carbonate In N,N-dimethyl-formamide at 90℃;71%
3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

2-chloromethyl-5-(2-fluoro-phenyl)-[1,3,4]oxadiazole
350672-17-2

2-chloromethyl-5-(2-fluoro-phenyl)-[1,3,4]oxadiazole

2-(5-(trifluoromethyl)pyridiloxymethyl)-5-(2-fluorophenyl)-1,3,4-oxadiazole

2-(5-(trifluoromethyl)pyridiloxymethyl)-5-(2-fluorophenyl)-1,3,4-oxadiazole

Conditions
ConditionsYield
With tetrabutylammomium bromide; potassium carbonate In N,N-dimethyl-formamide at 90℃;70%
2-(chloromethyl)-5-(4-chlorophenyl)-1,3,4-oxadiazole
24068-15-3

2-(chloromethyl)-5-(4-chlorophenyl)-1,3,4-oxadiazole

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

2-(5-(trifluoromethyl)pyridiloxymethyl)-5-(4-chlorophenyl)-1,3,4-oxadiazole

2-(5-(trifluoromethyl)pyridiloxymethyl)-5-(4-chlorophenyl)-1,3,4-oxadiazole

Conditions
ConditionsYield
With tetrabutylammomium bromide; potassium carbonate In N,N-dimethyl-formamide at 90℃;69%
3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

2-bromo-3-chloro-5-(trifluoromethyl)pyridine
75806-84-7

2-bromo-3-chloro-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With phosphorus(V) oxybromide at 150℃; for 6h; Temperature;58%
8-chloro-2,2-dimethyl-4-[1,2,4]triazol-1-yloctan-3-one
1217539-63-3

8-chloro-2,2-dimethyl-4-[1,2,4]triazol-1-yloctan-3-one

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

8-(3-chloro-5-trifluoromethylpyridin-2-yloxy)-2,2-dimethyl-4-[1,2,4]triazol-1-yloctan-3-one
1217539-65-5

8-(3-chloro-5-trifluoromethylpyridin-2-yloxy)-2,2-dimethyl-4-[1,2,4]triazol-1-yloctan-3-one

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 180℃; for 0.5h; microwave irradiation;33%
3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

3-methyl-1-{[methyl(phenyl)amino]carbonyl}-1H-imidazol-3-ium iodide

3-methyl-1-{[methyl(phenyl)amino]carbonyl}-1H-imidazol-3-ium iodide

methyl-phenyl-carbamic acid 3-chloro-5-trifluoromethyl-pyridin-2-yl ester
548766-54-7

methyl-phenyl-carbamic acid 3-chloro-5-trifluoromethyl-pyridin-2-yl ester

Conditions
ConditionsYield
With triethylamine In acetonitrile15%
2-[2-(5-fluoro-2-methoxyphenyl)-2-methylpropyl]-2-(trifluoromethyl)oxirane
271587-47-4

2-[2-(5-fluoro-2-methoxyphenyl)-2-methylpropyl]-2-(trifluoromethyl)oxirane

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

3-chloro-1-[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]-5-trifluoromethyl-1H-pyridin-2-one
727375-79-3

3-chloro-1-[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]-5-trifluoromethyl-1H-pyridin-2-one

Conditions
ConditionsYield
With sodium ethanolate In ethanol at 85℃;
3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

cyanomethyl bromide
590-17-0

cyanomethyl bromide

N-cyanomethyl-3-chloro-5-(trifluoromethyl)-2-pyridinone

N-cyanomethyl-3-chloro-5-(trifluoromethyl)-2-pyridinone

Conditions
ConditionsYield
With potassium carbonate In water; dimethyl sulfoxide
1-[3-chloro-5-(3,3-dichloroallyloxy)-2-methoxyphenyl]ethanone O-(2-hydroxyethyl)-oxime
918311-09-8

1-[3-chloro-5-(3,3-dichloroallyloxy)-2-methoxyphenyl]ethanone O-(2-hydroxyethyl)-oxime

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

1-[3-chloro-5-(3,3-dichloroallyloxy)-2-methoxyphenyl]ethanone O-[2-(3-chloro-5-trifluoromethylpyridin-2-yloxy)ethyl]oxime
918311-11-2

1-[3-chloro-5-(3,3-dichloroallyloxy)-2-methoxyphenyl]ethanone O-[2-(3-chloro-5-trifluoromethylpyridin-2-yloxy)ethyl]oxime

Conditions
ConditionsYield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20℃; Mitsunobu reaction;
3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

(RS,SR)-8-(3-chloro-5-trifluoromethylpyridin-2-yloxy)-2,2-dimethyl-4-[1,2,4]triazol-1-yloctan-3-ol

(RS,SR)-8-(3-chloro-5-trifluoromethylpyridin-2-yloxy)-2,2-dimethyl-4-[1,2,4]triazol-1-yloctan-3-ol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium carbonate / potassium iodide / N,N-dimethyl-formamide / 0.5 h / 180 °C / microwave irradiation
2.1: titanium tetrachloride / dichloromethane / 0.5 h / -30 °C
2.2: 14 h / -30 - 20 °C
View Scheme
3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

(RR,SS)-8-(3-chloro-5-trifluoromethylpyridin-2-yloxy)-2,2-dimethyl-4-[1,2,4]triazol-1-yloctan-3-ol

(RR,SS)-8-(3-chloro-5-trifluoromethylpyridin-2-yloxy)-2,2-dimethyl-4-[1,2,4]triazol-1-yloctan-3-ol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / potassium iodide / N,N-dimethyl-formamide / 0.5 h / 180 °C / microwave irradiation
2: sodium tetrahydroborate; methanol / 14 h / 0 - 20 °C
View Scheme
3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

methyl (E)-2-[2-(bromomethyl)phenyl]-2-(methoxyimino)acetate
133409-72-0

methyl (E)-2-[2-(bromomethyl)phenyl]-2-(methoxyimino)acetate

(E)-2-(2-(((3-chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)methyl)phenyl)-2-(methoxyimino)-N-methylacetamide

(E)-2-(2-(((3-chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)methyl)phenyl)-2-(methoxyimino)-N-methylacetamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium carbonate / butanone / 0.5 h
1.2: 5 h / 80 °C
2.1: methanol / 3 h / 20 °C
View Scheme
methyl (1s,4s)-4-hydroxy-2'-oxo-1',2'-dihydrospiro[cyclohexane-1,3'-indole]-5'-carboxylate

methyl (1s,4s)-4-hydroxy-2'-oxo-1',2'-dihydrospiro[cyclohexane-1,3'-indole]-5'-carboxylate

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

(1r,4r)-4-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)-2'-oxo-1',2'-dihydrospiro[cyclohexane-1,3'-indole]-5'-carboxylic acid

(1r,4r)-4-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)-2'-oxo-1',2'-dihydrospiro[cyclohexane-1,3'-indole]-5'-carboxylic acid

Conditions
ConditionsYield
Stage #1: methyl (1s,4s)-4-hydroxy-2'-oxo-1',2'-dihydrospiro[cyclohexane-1,3'-indole]-5'-carboxylate; 3-chloro-5-(trifluoromethyl)-2-hydroxypyridine With di-isopropyl azodicarboxylate In toluene at 80℃; for 3h;
Stage #2: With water; sodium hydroxide In tetrahydrofuran; methanol at 50℃; for 3h;
12.1 mg
methyl (1r,4r)-4-hydroxy-2'-oxo-1',2'-dihydrospiro[cyclohexane-1,3'-pyrrolo[3,2-b]pyridine]-5'-carboxylate

methyl (1r,4r)-4-hydroxy-2'-oxo-1',2'-dihydrospiro[cyclohexane-1,3'-pyrrolo[3,2-b]pyridine]-5'-carboxylate

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

C20H17ClF3N3O4

C20H17ClF3N3O4

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In toluene at 10 - 35℃; for 16h;
3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

3-chloro-4-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)aniline
76471-06-2

3-chloro-4-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)aniline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C
2: ammonium chloride; iron / ethanol; water / 6 h / Reflux
View Scheme

76041-71-9Relevant articles and documents

A for the synthesis of anti-cancer auxiliary drug pyridine medical process for the preparation of intermediates

-

Paragraph 0025, (2017/01/26)

The invention relates to the field of medical chemistry and discloses a method for synthesizing a pyridine medical intermediate, namely 2-bromo-3-chloro-5-trifluoromethyl pyridine, for synthesizing anti-cancer auxiliary medicines. The method comprises the following steps of: (1) reacting 6-hydroxynicotinic acid, hydrofluoric acid and sulfur tetrafluoride at the temperature of between 100 and 120DEG C and under the pressure of 0.1-0.3MPa, and adding water to obtain 2-hydroxy-5-trifluoromethyl pyridine; (2) reacting with N-chlorosuccinimide, and performing water precipitation to obtain 3-chloro-5-trifluoromethyl-2-hydroxypyridine; and (3) adding excessive phosphorus oxybromide, reacting at the temperature of between 145 and 160DEG C for 5 to 8 hours, cooling, violently stirring at the temperature of between -5 and 0DEG C, extracting, combining organic phases, drying, filtering, performing spin drying, and purifying by using a silica gel column. According to the method, raw materials are readily available, the cost is low, the method is suitable for industrial production and the yield exceeds 38 percent.

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