- Aqueous hydrofluoric acid catalyzed facile synthesis of 2,3,6-substituted quinoxalines
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A versatile synthetic route for the preparation of 2,3,6-trisubstituted quinoxalines in excellent yield is developed from θ-diamines and 1,2-dicarbonyl compounds in which aqueous hydrofluoric acid was employed as the medium and catalyst. Other salient features of this protocol include milder conditions, absence of coupling agents, and easy workup procedures.
- Chandra Shekhar,Ravi Kumar,Sathaiah,Raju,Srinivas,Shanthan Rao,Narsaiah
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p. 1504 - 1508
(2015/04/27)
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- TRIAZOLOPYRAZINE DERIVATIVES AND THEIR USE FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS
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The present invention is directed to triazolopyrazine compounds of Formula (I). Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds as therapeutic agents treating neurological and psychiatric disorders.
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Page/Page column 19
(2013/03/26)
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- TRIAZOLO COMPOUNDS AS PDE10 INHIBITORS
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The present invention provides compounds of formula (Ia) and (Ib) wherein R1, R2, R3 and R4 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit PDE10A and can be used as medicaments.
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Page/Page column 161
(2014/01/07)
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- NON-PEPTIDE GLP-1 AGONISTS
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Novel non-peptide GLP-1 agonists, pharmaceutical compositions comprising them, use of the non-peptide GLP-1 agonists for the preparation of pharmaceutical compositions and methods for the treatment and/or prevention of disorders and diseases wherein an ac
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Page/Page column 48-49
(2010/02/13)
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- The facile one pot synthesis of 6-substituted 2(1H)-quinoxalinones
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Facile one pot synthesis of 6-substituted 2(1H)-quinoxalinones and these reaction mechanisms are described.The intramolecular cyclization reaction of 4'-substituted 2'-nitroacetoacetanilides in aqueous basic medium and the reduction of 6-substituted 2(1H)-quinoxalinone-4-oxide wit sodium borohydride or sodium hydrogensulfite were studied in detail
- Sakata, Gozyo,Makino, Kenzi,Morimoto, Katsushi
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p. 143 - 151
(2007/10/02)
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