- Continuous preparation method of flutriafol
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The invention relates to a continuous preparation method of flutriafol. 1,2,4-triazole and 1-(2-fluorophenyl)-1-(4-fluorophenyl) ethylene oxide react in a microchannel continuous flow reactor in the presence of an organic solvent and a soluble alkali to obtain the flutriafol. The method is short in reaction time and high in automatic production level, promotes the competitiveness of an enterprise,is small in safety hazard in the process of synthesizing the target product, reduces the risk coefficient, is high in yield of the target product, simple in post treatment and little in solid waste,and realizes a cleaner and environment-friendly production process.
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Paragraph 0009; 0040-0048
(2019/02/26)
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- A synthesis method of flutriafol (by machine translation)
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The invention relates to a synthesis method of flutriafol, the halogenated methane and dimethyl sulfoxide in the 0 - 120 °C reaction under 1 - 48 H-; adding solid alkali and 2, 4' - difluoro benzophenone, temperature control in the 0 - 80 °C, reaction 1 - 25 the H; adding triazole, temperature control in the 50 - 200 °C, reaction 1 - 20 the H, after the reaction, filtered, to remove solvent, washing, crystallization get said teflubenzuron. In the present invention dimethyl sulfoxide is used as the reaction raw material, but also as the solvent, avoiding mixed solvent separation difficulties, and, dimethyl sulfoxide and halogenated methane to replace the existing technology to the environment in the pressure of the dimethyl sulfide and highly toxic chemicals dimethyl sulfate, so that the present invention is friendly to the environment, in addition, the invention mild reaction conditions, the reaction time is short, high yield, high product quality, three waste emissions low, produces only a sole inorganic salt, of the present invention thereby the productivity is high, economic efficiency is good. (by machine translation)
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Paragraph 0034; 0037; 0039-0054
(2019/01/08)
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- FUNGICIDAL MIXTURES
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The present invention relates to fungicidal mixtures comprising, as active components, 1) azolylmethyloxiranes of the general formula I wherein the variables have the meanings described in the application, 2) a fungicidal compound II, and 3) optionally a further fungicidal compound II, where the compounds II of components 2 and 3 independently of one another are selected from the group consisting of the compounds described in the application, with the proviso that components 2 and 3 are not identical, and to the use of the fungicidal mixtures for controlling phytopathogenic fungi and to the compositions comprising them.
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- FUNGICIDAL MIXTURES
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The present invention relates to fungicidal mixtures comprising, as active components, 1) azolylmethyloxiranes of the general formula I in which the variables have the meanings described in the application, and 2) a fungicidal compound II, where the compounds II of component 2 are selected from among the compounds described in the application, and to the use of the fungicidal mixtures for controlling phytopathogenic fungi and to the compositions comprising them.
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- Fungicide compositions
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Compositions of azole fungicides exhibiting reduced eye irritation are prepared by replacing a significant portion of the hydrocarbon solvent with a combination of propylene glycol and a long chain fatty alcohol.
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- Isomerization process
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Transformation of specified 4H-substituted-1,2,4-triazoles into their 1H-substituted isomers by heating at a temperature of 150° C. to 300° C. in the presence of a base and, essentially, in the absence of a polar aprotic solvent.
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- Fungicide compositions
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A fungicide composition having reduced eye irritation comprising in percent by weight based on the weight of the composition 5-50% of an azole fungicide which irritates the eye in combination with an aromatic hydrocarbon, 20-40% propylene glycol, 1-20% fatty alcohol having at least 10 carbon atoms, 10-40% surfactant and less than about 20% aromatic hydrocarbon.
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