- An Intramolecular Iodine-Catalyzed C(sp3)?H Oxidation as a Versatile Tool for the Synthesis of Tetrahydrofurans
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The formation of ubiquitous occurring tetrahydrofuran patterns has been extensively investigated in the 1960s as it was one of the first examples of a non-directed remote C?H activation. These approaches suffer from the use of toxic transition metals in overstoichiometric amounts. An attractive metal-free solution for transforming carbon-hydrogen bonds into carbon-oxygen bonds lies in applying economically and ecologically favorable iodine reagents. The presented method involves an intertwined catalytic cycle of a radical chain reaction and an iodine(I/III) redox couple by selectively activating a remote C(sp3)?H bond under visible-light irradiation. The reaction proceeds under mild reaction conditions, is operationally simple and tolerates many functional groups giving fast and easy access to different substituted tetrahydrofurans.
- Br?se, Stefan,Koch, Vanessa
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supporting information
p. 3478 - 3483
(2021/07/22)
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- NITROGENOUS HETEROCYCLIC DERIVATIVES AND THEIR APPLICATION IN DRUGS
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The invention relates to the field of medicine, discloses new nitrogen heterocyclic derivatives, preparation method thereof and as medicament in particular as the treatment and prevention of treating tissue fibrosis of the medicament. The invention also discloses a pharmaceutically acceptable compound of the present invention comprise a pharmaceutical composition and methods for using the composition for the treatment of the human or animal tissue fibrosis of diseases, in particular for treating the human or animal renal interstitial fibrosis, glomerular sclerosis, hepatic fibrosis, pulmonary fibrosis, peritoneal fibrosis, myocardial fibrosis, skin fibrosis, after the operation of adhering, benign prostate hypertrophy, bone-myocardial, scleroderma, multiple sclerosis, pancreas fibrosis, liver cirrhosis, myosarcoma, neurofibromatosis, interstitial pulmonary fibrosis, diabetic nephropathy, Alzheimer's disease or vascular fibrosis disease in use. (by machine translation)
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- Nitrogenous Heterocyclic Derivatives And Their Application In Drugs
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The present invention relates to the field of medicine, provided herein are novel nitrogenous heterocyclic compounds, their preparation methods and their uses as drugs, especially for treatment and prevention of tissue fibrosis. Also provided herein are pharmaceutically acceptable compositions comprising the nitrogenous heterocyclic compounds and the uses of the compositions in the treatment of human or animal tissue fibrosis, especially for human or animal renal interstitial fibrosis, glomerular sclerosis, liver fibrosis, pulmonary fibrosis, peritoneal fibrosis, myocardial fibrosis, dermatofibrosis, postsurgical adhesion, benign prostatic hyperplasia, skeletal muscle fibrosis, scleroderma, multiple sclerosis, pancreatic fibrosis, cirrhosis, myosarcoma, neurofibroma, pulmonary interstitial fibrosis, diabetic nephropathy, alzheimer disease or vascular fibrosis.
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Paragraph 0769
(2015/03/31)
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- NITROGENOUS HETEROCYCLIC DERIVATIVES AND THEIR APPLICATION IN DRUGS
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The present invention relates to the field of medicine, provided herein are novel nitrogenous heterocyclic compounds, their preparation methods and their uses as drugs, especially for treatment and prevention of tissue fibrosis. Also provided herein are pharmaceutically acceptable compositions comprising the nitrogenous heterocyclic compounds and the uses of the compositions in the treatment of human or animal tissue fibrosis, especially for human or animal renal interstitial fibrosis, glomerular sclerosis, liver fibrosis, pulmonary fibrosis, peritoneal fibrosis, myocardial fibrosis, dermatofibrosis, postsurgical adhesion, benign prostatic hyperplasia, skeletal muscle fibrosis, scleroderma, multiple sclerosis, pancreatic fibrosis, cirrhosis, myosarcoma, neurofibroma, pulmonary interstitial fibrosis, diabetic nephropathy, alzheimer disease or vascular fibrosis.
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Paragraph 00444
(2014/02/15)
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- Photochemical functionalization of allyl benzoates by C-H insertion
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The photoreactivity of allyl benzoates, containing an electron-rich double bond, has been explored by irradiation at 305 nm in different solvents. Solvent addition products arising from an insertion of the alpha H-C bonds of THF, dioxane, and i-PrOH to the allylic double bond was realized. The observed reactivity depended on reaction conditions and substitution pattern of the substrate. A DFT study on this unusual reaction was performed allowing the formulation of two mechanistic pathways.
- Pibiri, Ivana,Palumbo Piccionello, Antonio,Pace, Andrea,Barone, Giampaolo,Buscemi, Silvestre
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p. 6065 - 6069
(2013/07/19)
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- NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS
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The present application relates to isothiazolylidene containing compounds of Formula (I) wherein R1, R2, R3, R4, and L are as defined in the specification, compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions.
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Page/Page column 95
(2010/06/11)
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- NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS
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The present application relates to isothiazolylidene containing compounds of Formula (I) wherein R1, R2, R3, R4, and L are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
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Page/Page column 79
(2008/12/08)
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- Stereoselective ring expansion via bicyclooxonium ion. A novel approach to oxocanes
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(equation presented) The stereoselective 1,4-rearrangement-ring expansion of tetrahydrofurans via bicyclo[3.3.0]oxonium ions was developed to synthesize oxocanes. On the basis of this rearrangement, the stereoselective synthesis of 2,8-syn-2,8-dimethyloxo
- Sakamoto, Yasuharu,Tamegai, Kyoko,Nakata, Tadashi
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p. 675 - 678
(2007/10/03)
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- Facile Electroreduction of Methyl Esters and N,N-Dimethylamides of Aliphatic Carboxylic Acids to Primary Alcohols
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In the presence of t-BuOH, methyl esters and N,N-dimethylamides of aliphatic carboxylic acids are electroreduced at a Mg cathode to the corresponding primary alcohols.In the presence of t-BuOD instead of t-BuOH, the electroreduction of the esters gives the corresponding 1,1-dideuterated alcohol.In all cases, the yields are excellent.
- Shono, Tatsuya,Masuda, Haruhisa,Murase, Hiroaki,Shimomura, Masatoshi,Kashimura, Shigenori
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p. 1061 - 1063
(2007/10/02)
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- DEPLACEMENTS HOMOLYTIQUES INTRAMOLECULAIRES . 12 - DECOMPOSITION INDUITE DE PEROXYDES ETHYLENIQUES : INFLUENCE DE LA LONGUEUR DE LA CHAINE
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Products analyses of the thermolyses of the peroxides CH2=CH-(CH2)nOOtBu, 1, (n=1-5) showed that an induced decomposition of 1 occurred for n=1,2,3,4.Free radical additions of THF, carbon tetrachloride, bromotrichloromethane to 1 have been performed at lower temperature; they allowed, through the isolation of an adduct peroxide, at least in one case for each peroxide, to prove that a two-steps mechanism (addition of radical Z. to the double bond, intramolecular homolytic displacement) is involved in the induced decomposition of 1.The order of magnitude of the rate constants of these SHi reactions could be estimated.
- Bourgeois, M. J.,Maillard, B.,Montaudon, E.
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p. 5309 - 5320
(2007/10/02)
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- DEPLACEMENTS HOMOLYTIQUES INTRAMOLECULAIRES III-DECOMPOSITION DU PEROXYDE D'ALLYLE ET DE t-BUTYLE DANS LES ETHERS ET LES CYCLANES: EPOXY-2,3 PROPANATION DE CES SOLVANTS
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Product analysis of the thermolysis of allyl t-butyl peroxide in cyclohexane and tetrahydrofuran shows that an important induced decomposition of the peroxide occurs by the addition of radicals derived from the solvent, to the peroxide double bond, followed by an intramolecular homolytic displacement of the t-butoxyl group.Such a reaction is a 2,3-epoxypropanation of the solvent in which the initiator is decomposed.The reaction is shown to be general, by using other ethers and cycloalkanes as solvents.
- Maillard, B.,Montaudon, E.,Rakotomanana, F.,Bourgeois, M. J.
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p. 5039 - 5044
(2007/10/02)
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