- Mechanism-based design, synthesis and biological studies of N 5-substituted tetrahydrofolate analogs as inhibitors of cobalamin-dependent methionine synthase and potential anticancer agents
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A number of 8-deazatetrahydrofolates bearing electrophilic groups on N 5 were designed and synthesized based on the action mechanism of methionine synthase, and their biological activities were investigated as well. Compounds (11b, 12b and 16)
- Zhang, Zhili,Tian, Chao,Zhou, Shouxin,Wang, Wei,Guo, Ying,Xia, Jie,Liu, Zhenming,Wang, Biao,Wang, Xiaowei,Golding, Bernard T.,Griff, Roger J.,Du, Yansheng,Liu, Junyi
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p. 228 - 236
(2013/02/22)
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- Pyridopyrimidines. 12. Synthesis of 8-deaza analogues of aminopterin and folic acid
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A new, general approach to the synthesis of numerous 8-deazafolate and 8-deazaaminopterin analogues is described. The key intermediate, 6-(acetoxymethyl)-2,4-dichloropyrido[3,2-d]pyrimidine, was prepared by chlorination of the 2,4-dioxo derivative which,
- Srinivasan, Ananthachari,Broom, Arthur D.
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p. 1777 - 1781
(2007/10/02)
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