769065-62-5Relevant articles and documents
New synthesis of β-aminoacid derivatives via hydroamination in Dimcarb
Hess,Dunkel,Muller
, p. 591 - 597 (2007/10/02)
A new selective hydro-dimethylamination method for unsaturated carboxylic acid derivatives with the pronucleophilic dimethylamine-precursor Dimcarb is described, which allows effective synthesis of hydro-β-dimethylamino-acid derivatives and unsaturated amides. Simple HMO quantum chemical calculation together with 1H NMR examination permits the prediction of suitable substrates, coupling position for dimethylamine as well as for mechanistical insights and optimal reaction course.