- Synthetic Routes to the Carcinogen IQ and Related 3H-Imidazoquinolines
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2-Amino-3-methyl-3H-imidazoquinoline (IQ, 1a) and four new IQ homologues, viz. its 7-methyl, 8-methyl, 9-methyl and 7,9-dimethyl derivatives 1c-1f, have been conveniently synthesized from the appropriate 6-methoxyquinolines 3 rather than from the p
- Ronne, Erik,Grivas, Spiros,Olsson, Kjell
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p. 823 - 830
(2007/10/02)
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- Syntheses of 2-Amino-3,4-dimethyl-3H-imidazoquinoline and Its Related Compounds
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The strongly mutagenic compound, 2-amino-3,4-dimethyl-3H-imidazoquinoline (Me-IQ), isolated from broiled sardines was synthesized from 6-amino-7-methylquinoline.Several structurally related compounds were also synthesized to clarify the structure-a
- Kasai, Hiroshi,Nishimura, Susumu
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p. 2233 - 2235
(2007/10/02)
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- STRUCTURE AND CHEMICAL SYNTHESIS OF ME-IQ, A POTENT MUTAGEN ISOLATED FROM BROILED FISH
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Structure of a mutagenic compound (Me-IQ) isolated from broiled fish was determined to be 2-amino-3,4-dimethylimidazoquinoline based on the mass-, UV- and 1HNMR-spectra and chemical synthesis.Me-IQ showed strong mutagenic activity towards Salmonella typhimurium TA98 in the presence of S-9 mix.
- Kasai, Hiroshi,Yamaizumi, Ziro,Wakabayashi, Keiji,Nagao, Minako,Sugimura, Takashi,et al.
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p. 1391 - 1394
(2007/10/02)
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