- Synthesis and characterization of dendritic structures incorporating phosphorus, sulfur, and silicon
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Two new families of small phosphorus-containing dendrons, having as core either a phenol protected by a t-butyldimethylsilyl group or a terminal alkyne protected by a trimethylsilyl group have been synthesized. Both families comprise P, S, and Si (and oth
- Padié, Clément,Hameau, Aurélien,Duhayon, Carine,Majoral, Jean-Pierre,Caminade, Anne-Marie
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Read Online
- Two-dimensional graphdiyne analogue Co-coordinated porphyrin covalent organic framework nanosheets as a stable electrocatalyst for the oxygen evolution reaction
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As a rising-star 2D carbon material, graphdiyne (GDY), has received wide attention for its promising applications in many fields due to its unique butadiyne structure. However, owing to a lack of active sites, GDY just serves as a catalyst support in the electrocatalytic process, especially OER. Developing a new monomer with highly active centers for GDY is an effective strategy to overcome this unfavorable factor. Herein, a metalloporphyrin-based GDY analogue (Co-PDY) with a unique π-conjugated structure was innovatively designed and prepared through a Glaser-Hay coupling reaction on copper foam. Cobalt centers of metalloporphyrin moieties can provide numerous electrocatalytic sites for OER; also, the electrons can be transferred rapidly through the butadiyne linkages in the electrocatalytic process. The expanded pore structure (2.34 nm) of Co-PDY also serves as an effective transmission channel for small molecule diffusion to maintain the following catalytic process. These three factors altogether endow Co-PDY with excellent OER catalytic performance, including a small overpotential of 270 mV at 10 mA cm-2, a low Tafel slope of (99 mV dec-1), and promising long-term stability and durability. Meanwhile, the Co-PDY/CF electrode also displayed an acceptable electrocatalytic performance for HER in alkaline media. Profiting from the above characteristics, Co-PDY can be regarded as a promising electrocatalyst for new energy devices.
- Huang, Hao,Li, Fumin,Zhang, Ying,Chen
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Read Online
- A novel RET inhibitor. Pharmaceutical composition and use thereof
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The invention belongs to the field of medicines, and relates to a novel RET inhibitor, a pharmaceutical composition and application thereof. In particular, the invention relates to a compound represented by formula (I), a stereoisomer, a tautomer, an oxynitride, a solvate, a metabolite, a pharmaceutically acceptable salt or prodrug thereof, I said compound and a pharmaceutical composition thereof for the manufacture of a medicament, in particular for the treatment and prophylaxis and RET of diseases and disorders associated with irritable bowel syndrome.
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Paragraph 0332-0335
(2021/11/26)
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- Expanded Cyclotetrabenzoins
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Cyclobenzoins are shape-persistent macrocycles of interest in the preparation of optoelectronic and porous materials. New cyclotetrabenzoins derived from biphenyl, naphthalene, and tolane skeletons were synthesized using N-heterocyclic carbene-catalyzed b
- Eisterhold, Andrew M.,Puangsamlee, Thamon,Otterbach, Steffen,Br?se, Stefan,Weis, Patrick,Wang, Xiqu,Kutonova, Ksenia V.,Miljani?, Ognjen ?.
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supporting information
p. 781 - 785
(2021/01/26)
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- Bimetallic conjugated microporous polymer derived B,N-doped porous carbon wrapped Co3Fe7alloy composite as a bifunctional oxygen electrocatalyst for a breathing Zn-air battery
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The exploration and development of high-performance, durable and economic bifunctional electrocatalysts towards the oxygen reduction reaction (ORR) and the oxygen evolution reaction (OER) is essential but challenging for the development of rechargeable Zn
- Bai, Jingkun,Bian, Weiwei,Dou, Jinli,Guo, Wenxue,Lu, Jingjing,Luan, Xiujuan,Luo, Haotian,Zhang, Chunli,Zhang, Teng,Zhang, Xueli,Zhou, Baolong
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supporting information
p. 21020 - 21030
(2021/12/09)
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- α-Diazo Sulfonium Triflates: Synthesis, Structure, and Application to the Synthesis of 1-(Dialkylamino)-1,2,3-triazoles
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The one-pot synthesis of a series of sulfonium salts containing transferable diazomethyl groups is described, and the structure of these compounds is elucidated by X-ray crystallography. Under photochemical conditions, reaction of these salts with N,N-dialkyl hydrazones affords 1-(dialkylamino)-1,2,3-triazoles via diazomethyl radical addition to the azomethine carbon followed by intramolecular ring closure. The straightforward transformation of the structures thus obtained into mesoionic carbene–metal complexes is also reported and the donor properties of these new ligands characterized.
- Li, Xiangdong,Golz, Christopher,Alcarazo, Manuel
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supporting information
p. 6943 - 6948
(2021/02/26)
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- FLUORESCENT SYSTEMS FOR BIOLOGICAL IMAGING AND USES THEREOF
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The invention relates to compounds of formula I, in which Y, Ar1, Ar2, X, R1 and R2 are defined herein, and to their use in a variety of biological imaging techniques and therapeutic methods. In aspects, the invention relates to conjugates comprising the compounds of formula I and their associated uses and therapeutic uses.
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Page/Page column 26; 28-29
(2021/02/12)
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- γ-Carboline synthesis enabled by Rh(iii)-catalysed regioselective C-H annulation
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A redox-neutral Rh(iii)-catalyzed C-H annulation of indolyl oximes was developed. Relying on the use of various alkynyl silanes as the terminal alkyne surrogates, the reaction exhibited a reverse regioselectivity, thus giving an exclusive and easy way for the synthesis of a wide range of substituent free γ-carbolines at C3 position with high efficiency. Deuterium-labelling experiments and kinetic analysis have preliminarily shed light on the working mode of this catalytic system. This journal is
- Jiang, Bo,Jia, Jingwen,Sun, Yufei,Wang, Yichun,Zeng, Jing,Bu, Xiubin,Shi, Liangliang,Sun, Xiaoying,Yang, Xiaobo
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supporting information
p. 13389 - 13392
(2020/11/10)
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- Cellular localisation of structurally diverse diphenylacetylene fluorophores
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Fluorescent probes are increasingly used as reporter molecules in a wide variety of biophysical experiments, but when designing new compounds it can often be difficult to anticipate the effect that changing chemical structure can have on cellular localisa
- Adams, Candace,Ambler, Carrie A.,Bain, Angus J.,Blacker, Thomas S.,Callaghan, Daniel,Chisholm, David R.,Girkin, John M.,Hughes, Joshua G.,Humann, Rachel,Lembicz, Nicola K.,Pujol, Alba,Whiting, Andrew
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p. 9231 - 9245
(2020/12/03)
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- RET INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
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Provided herein are a RET inhibitor, a pharmaceutical composition thereof and uses thereof. In particular, provided is a compound having Formula (I) or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof. Provided is a pharmaceutical composition comprising the compound, and uses of the compound and pharmaceutical composition thereof for the preparation of a medicament, in particular for treatment and prevention of RET-related diseases and conditions, including cancer, irritable bowel syndrome, and/or pain associated with irritable bowel syndrome.
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Paragraph 00324
(2020/07/06)
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- RET INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
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Provided herein are a RET inhibitor, a pharmaceutical composition thereof and uses thereof. In particular, provided is a compound having Formula (I) or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof. Provided is a pharmaceutical composition comprising the compound, and uses of the compound and pharmaceutical composition thereof for the preparation of a medicament, in particular for treatment and prevention of RET-related diseases and conditions, including cancer, irritable bowel syndrome, and/or pain associated with irritable bowel syndrome.
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Paragraph 00230; 00322; 00559
(2020/07/05)
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- Tuning the Cell Uptake and Subcellular Distribution in BODIPY–Carboranyl Dyads: An Experimental and Theoretical Study
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A set of BODIPY-carboranyl dyads synthesized by a Sonogashira cross-coupling reaction, where different C-substituted ortho- and meta-carboranyl fragments have been linked to a BODIPY fluorophore is described. Chemical, photophysical and physicochemical an
- Labra-Vázquez, Pablo,Flores-Cruz, Ricardo,Galindo-Hernández, Aylin,Cabrera-González, Justo,Guzmán-Cedillo, Cristian,Jiménez-Sánchez, Arturo,Lacroix, Pascal G.,Santillan, Rosa,Farfán, Norberto,Nú?ez, Rosario
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supporting information
p. 16530 - 16540
(2020/10/30)
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- CONJUGATED OLIGOMER-BASED MACROCYCLES FOR LIVE CELL IMAGING
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A phenyleneethynylene macrocycle (PEMC) is constructed that is a cyclic or polycyclic oligo (oligophenyleneethynylene-co-polyamine) where a monodispersed oligophenyleneethynylene is coupled with a polyamine. The PEMC is formed by coupling a monodispersed di-aldehyde end-capped oligophenyleneethynylene with a polyamine to form a macrocyclic imine and reducing the imine to an amine. The PEMC is useful at entering living cells for the fluorescence imaging of the living cells without toxicity to the cells.
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Paragraph 0046-0047
(2020/12/29)
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- Bimodal Heterogeneous Functionality in Redox-Active Conjugated Microporous Polymer toward Electrocatalytic Oxygen Reduction and Photocatalytic Hydrogen Evolution
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The designing and development of heterogeneous catalysts for conversion of renewable energy to chemical energies by electrochemical as well as photochemical processes is at the forefront of energy research. In this work, two new donor–acceptor-based redox-active conjugated microporous polymers (CMPs) (TAPA-OPE-mix and TAPA-OPE-gly) are synthesized through Schiff base condensation reaction using a microwave synthesizer. Notably, the asymmetric and symmetric bola-amphiphilic nature of the OPE struts results in distinct nanostructuring and morphologies in the CMPs. Interestingly, both CMPs show impressive heterogeneous catalytic activity toward electrochemical O2 reduction and photocatalytic H2 evolution reactions, and therefore, act as bimodal electro- and photocatalytic porous organic materials. Furthermore, the redox-active property of the CMPs is exploited for in situ generation and stabilization of platinum nanoparticles (Pt), and these Pt@CMPs exhibit significantly enhanced photocatalytic activity.
- Singh, Ashish,Verma, Parul,Samanta, Debabrata,Singh, Tarandeep,Maji, Tapas Kumar
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p. 3810 - 3817
(2020/03/11)
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- Imidazopyridine-fused [1,3]diazepinones: modulations of positions 2 to 4 and their impacts on the anti-melanoma activity
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A series of 19 novel pyrido-imidazodiazepinones, with modulations of positions 2, 3 and 4 of the diazepine ring were synthesised and screened for their in vitro cytotoxic activities against two melanoma cell lines (A375 and MDA-MB-435) and for their poten
- Ali, Lamiaa M. A.,Baccon-Sollier, Paul Le,Cuq, Pierre,Lichon, Laure,Malki, Yohan,Masurier, Nicolas,Maye, Morgane,Vincent, Laure-Ana?s
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p. 935 - 949
(2020/04/17)
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- Diboron-Assisted Copper-Catalyzed Z-Selective Semihydrogenation of Alkynes Using Ethanol as a Hydrogen Donor
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We herein describe a B2Pin2-assisted copper-catalyzed semihydrogenation of alkynes. A variety of alkenes were obtained in good to excellent yields with Z-selectivity under mild reaction conditions. Mechanistic studies indicated that a transfer hydrogenation process was involved and ethanol acted as both a solvent and a hydrogen donor in this reaction. The present protocol enabled convenient synthesis of deuterium-substituted Z-alkenes such as Z-Combretastain A4-d2 in a high deuteration ratio by using readily available ethanol-d1 as the deuterium source.
- Bao, Hanyang,Zhou, Bingwei,Jin, Hongwei,Liu, Yunkui
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p. 3579 - 3589
(2019/03/11)
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- Star-Shaped Ruthenium Complexes as Prototypes of Molecular Gears
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The design and synthesis of two families of molecular-gear prototypes is reported, with the aim of assembling them into trains of gears on a surface and ultimately achieving controlled intermolecular gearing motion. These piano-stool ruthenium complexes i
- Abid, Seifallah,Andreoni, Leonardo,Erbland, Guillaume,Gisbert, Yohan,Guérin, Théo,Hashimoto, Yuichiro,Kammerer, Claire,Rapenne, Gwéna?l,Saffon-Merceron, Nathalie
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p. 16328 - 16339
(2019/11/28)
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- Intersystem Crossing in Naphthalenediimide–Oxoverdazyl Dyads: Synthesis and Study of the Photophysical Properties
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Oxoverdazyl (Vz) radical units were covalently linked to the naphthalenediimide (NDI) chromophore to study the effect of the radical on the photophysical properties, especially the radical enhanced intersystem crossing (REISC), which is a promising approach to develop heavy-atom-free triplet photosensitizers. Rigid phenyl or ethynylphenyl linkers between the two moieties were used, thus REISC and formation of doublet (D1, total spin quantum number S=1/2) and quartet states (Q1, S=3/2) are anticipated. The photophysical properties of the dyads were studied with steady-state and femtosecond/nanosecond transient absorption (TA) spectroscopies and DFT computations. Femtosecond transient absorption spectra show a fast electron transfer (1→D0 decay, and the slow decay component (2.0 μs; 20 %) to the Q1→D0 ISC. DFT computations indicated ferromagnetic interactions between the radical and chromophore (J=0.07–0.13 eV). Reversible formation of the radical anion of the NDI moiety by photoreduction of the radical-NDI dyads in the presence of sacrificial electron donor triethanolamine (TEOA) is achieved. This work is useful for design of new triplet photosensitizers based on the REISC effect.
- Hussain, Mushraf,Taddei, Maria,Bussotti, Laura,Foggi, Paolo,Zhao, Jianzhang,Liu, Qingyun,Di Donato, Mariangela
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supporting information
p. 15615 - 15627
(2019/11/19)
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- Phenyleneethynylene trimer-based rigid-flexible [2+2] macrocycles for nucleic acid labelling in live cells
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Fluorescent macromolecules were developed for intracellular labeling in live cells. Coupling rigid rod phenyleneethynylene trimers with flexible amphiphilic diamines via the imine-bond formation chemistry yielded rigid-flexible [2+2] macromolecules showing nucleic acid selectivity and nontoxicity in live cells.
- Moon, Joong Ho,Manandhar, Prakash,Torabi, Hooman,Rohman, Md Rumum,Mathivathanan, Logesh,Lee, Ka Hung,Irle, Stephan
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supporting information
p. 5930 - 5933
(2019/05/27)
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- Study on synthesis, characterization, and nonvolatile memory behavior of ferrocene-containing metallopolymers
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In this work, two metallopolymers (P1 and P2)were designed and synthesized through coupling of ferrocene-anchored fluorene derivatives with porphyrin and benzene based diethynyl ligand, respectively. The chemical structure and physical properties of these two metallpolymers were fully characterized, which indicate that these two metallopolymers are thermally stable and semiconducting. Then, sandwich-like organic resistive memory based on P1 and P2 for data storage were explored. The memory device testing results manifest that both P1 and P2 are of the stable electric bistability and show write once read many times memory (WORM)characteristics.
- Cheng, Xiaozhe,Md, Asaduzzaman,Lian, Hong,Zhong, Zheng,Guo, Hongen,Dong, Qingchen,Roy
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- Reticular Synthesis of Multinary Covalent Organic Frameworks
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Hexagonal hexaminophenyl benzene, tetragonal tetrakis(4-aminophenyl) ethane, and trigonal 1,3,5-tris(p-formylphenyl)benzene were all joined together by imine linkages to yield a 2D porous covalent organic framework with unprecedented tth topology, termed
- Zhang, Bing,Mao, Haiyan,Matheu, Roc,Reimer, Jeffrey A.,Alshmimri, Sultan A.,Alshihri, Saeed,Yaghi, Omar M.
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supporting information
p. 11420 - 11424
(2019/08/20)
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- Ionic liquids enhanced alkynyl schiff bases derivatives of fipronil synthesis and their cytotoxicity studies
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To obtain highly selective toxic derivatives of fipronil, a series of Schiff bases with an alkynyl group (3a–3k) were designed and synthesized from 4-ethynylbenzaldehyde (2) and 4-substituted 5-amino-N-arylpyrazole (1a–1k) via a nucleophilic addition elim
- Liu, Xiu,Huang, Linya,Chen, Hongjun,Li, Na,Yan, Chao,Jin, Chenzhong,Xu, Hanhong
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- Boosting hydrogen evolution by using covalent frameworks of fluorinated cobalt porphyrins supported on carbon nanotubes
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A cobalt(ii) tetrakis(2,3,5,6-tetrafluoro-4-ethynylphenyl)porphyrin (FCoP-H) was designed and synthesized. With carbon-nanotube-templated polymerization, covalent porphyrin frameworks using FCoP-H can be synthesized via the Hay-coupling. The resulting FCo
- Xu, Gelun,Lei, Haitao,Zhou, Guojun,Zhang, Chaochao,Xie, Lisi,Zhang, Wei,Cao, Rui
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p. 12647 - 12650
(2019/10/28)
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- Nickel-Catalyzed Selective Reduction of Carboxylic Acids to Aldehydes
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The direct reduction of carboxylic acids to aldehydes is a fundamental transformation in organic synthesis. The combination of an air-stable Ni precatalyst, dimethyl dicarbonate as an activator, and silane reductant effects this reduction for a wide variety of substrates, including pharmaceutically relevant structures, in good yields and with no overreduction to alcohols. Moreover, this methodology is scalable, allows access to deuterated aldehydes, and is also compatible with one-pot utilization of the aldehyde products.
- Iosub, Andrei V.,Morav?ík, ?tefan,Wallentin, Carl-Johan,Bergman, Joakim
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supporting information
p. 7804 - 7808
(2019/10/14)
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- Naphthalene Diimides Prepared by a Straightforward Method and Their Characterization for Organic Electronics
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A new approach for the synthesis of acetylene-substituted naphthalene diimides in polar solvents with PdCl2, Et3N, and electrolytic copper powder was developed. This simplified approach allows for high-throughput synthesis, and the r
- Korzec, Mateusz,Kotowicz, Sonia,?aba, Katarzyna,?apkowski, Mieczys?aw,Ma?ecki, Jan Grzegorz,Smolarek, Karolina,Ma?kowski, Sebastian,Schab-Balcerzak, Ewa
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p. 1756 - 1760
(2018/04/27)
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- Facile preparation and investigation of the properties of single molecular POSS-based white-light-emitting hybrid materials using click chemistry
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Recently, organic white light emitting devices (OWLEDs) have attracted great interest in flexible displays and solid state lighting devices. Here we report a kind of novel POSS-based white-light-emitting single molecular nanohybrid (POSS-WLED), which was
- Zhao, Gang,Zhu, Yakun,Guang, Shanyi,Ke, Fuyou,Xu, Hongyao
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p. 555 - 563
(2017/12/28)
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- Metallophthalocyanine-based redox active metal-organic conjugated microporous polymers for OER catalysis
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We report the design and synthesis of two Co2+ and Zn2+ phthalocyanine (PC)-based redox active metal-organic conjugated microporous polymers (MO-CMP), CoCMP and ZnCMP, respectively, obtained by a Schiff base condensation reaction. CoCMP, where Co2+ is stabilized by N4-coordination of PC, has shown stable and efficient electrocatalytic activity towards the OER with a low overpotential of 340 mV.
- Singh, Ashish,Roy, Syamantak,Das, Chayanika,Samanta, Debabrata,Maji, Tapas Kumar
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p. 4465 - 4468
(2018/05/03)
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- POLYCYCLIC AMINES AS OPIOID RECEPTOR MODULATORS
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The present invention provides a genus of polycyclic amines that are useful as opioid receptor modulators. The compounds of the invention are useful in both therapeutic and diagnostic methods, including for treating pain, neurological disorders, cardiac disorders, bowel disorders, drug and alcohol addiction, drug overdose, urinary disorders, respiratory disorders, sexual dysfunction, psoriasis, graft rejection or cancer.
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Paragraph 0129; 0255
(2018/10/11)
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- Halogen-Bonded Supramolecular Capsules in the Solid State, in Solution, and in the Gas Phase
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Supramolecular capsules were assembled by neutral halogen bonding (XB) and studied in the solid state, in solution, and in the gas phase. The geometry of the highly organized capsules is shown by an X-ray crystal structure which features the assembly of t
- Dumele, Oliver,Schreib, Benedikt,Warzok, Ulrike,Trapp, Nils,Schalley, Christoph A.,Diederich, Fran?ois
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supporting information
p. 1152 - 1157
(2017/01/18)
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- Influence of a D-π-A system through a linked unit of double and triple bonds in a triarylene bridge for dye-sensitised solar cells
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Herein, eight metal-free organic dyes (YH-1-YH-8) containing olefin or acetylene as π-spacer linkages in a triarylene bridge were synthesised. Moreover, two dyes (1N-PPP and 1N-PPS) without olefin and triple bonds as π-spacer linkages were used as references. The photophysical and electrochemical properties of the dyes were characterised, and the dyes were then used to fabricate dye-sensitised solar cells (DSSCs). We demonstrated the use of a D-π-A dipolar system by employing arylamine derivatives as an electron donor, triarylene with iterative olefin or acetylene as a π-bridge, and cyanoacrylic acid as an electron acceptor. YH-1 had olefin as a repeating unit in the triarylene bridge and exhibited broad absorption, favourable short-circuit photocurrent density (Jsc), and favourable open-circuit voltage (Voc) when used in a film morphology with DCA as a coabsorbent. The optimal device exhibited a Jsc of 16.23 mA cm-2, a Voc of 650 mV, and a fill factor of 0.67, corresponding to an overall conversion efficiency of 7.08%. The photophysical properties of the DSSCs were analysed using time-dependent density functional theory with the B3LYP functional.
- Huang, Rui-Yu,Chiu, Yu-Hsiang,Chang, Yu-Hsuang,Chen, Kew-Yu,Huang, Pei-Ting,Chiang, Ting-Hsuan,Chang, Yuan Jay
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supporting information
p. 8016 - 8025
(2017/08/14)
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- Application of polymer microspheres to Raman detection
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The invention discloses application of polymer microspheres to Raman detection. Methacrylate/amide polymer monomers or styrene polymer monomers containing alkynyl, cyano, azido or a carbon-deuterium bond group are prepared into the polymer microspheres with the particle diameter from a nanometer grade to a micron grade through an emulsion polymerization or dispersion polymerization method; the polymer microspheres have a remarkable Raman signal under the condition of no metal sensitization structure; and a Raman characteristic peak signal is located in a Raman quiet zone (1800cm to 2800cm) in a living organism and can be used as a marker for biological imaging.
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Paragraph 0115-0118
(2018/03/13)
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- Synthesis of Phenalenyl-Fused Pyrylium Cations: Divergent C?H Activation/Annulation Reaction Sequence of Naphthalene Aldehydes with Alkynes
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Described herein is the synthesis of stable oxonium-doped polycyclic aromatic hydrocarbons (PAHs) by the rhodium-catalyzed C?H activation/annulations of naphthalene-type aldehydes with internal alkynes. This protocol provides four divergent reaction types, including two unexpected annulations with an oxygen transposition process, which lead to diverse types of phenalenyl-fused pyrylium cations comprising a four-, five-, or six-ring-fused π-conjugated core. The annulations exhibit an exquisite regioselectivity and a high tolerance of sensitive functional groups. These PAHs feature intriguing photophysical properties such as full-color tunable fluorescence emission, high quantum yield, and positively charged core, and can be reduced easily to the phenalenyl radicals.
- Yin, Jiangliang,Tan, Meiling,Wu, Di,Jiang, Ruyong,Li, Chengming,You, Jingsong
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supporting information
p. 13094 - 13098
(2017/09/18)
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- SILICON BASED DRUG CONJUGATES AND METHODS OF USING SAME
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Described herein are silicon based conjugates capable of delivering one or more payload moieties to a target cell or tissue. Contemplated conjugates may include a silicon-heteroatom core, one or more optional catalytic moieties, a targeting moiety that permits accumulation of the conjugate within a target cell or tissue, one or more payload moieties (e.g., a therapeutic agent or imaging agent), and two or more non-interfering moieties covalently bound to the silicon-heteroatom core.
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Paragraph 0728; 0738; 0739
(2017/08/07)
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- Synthesis, characterization and crystal structure of 4′-ethynylflavanone and its chalcone precursor
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The synthesis of (E)-4-ethynyl-2′-hydroxychalcone (7) and the 4′-ethynylflavanone (8), it's spectroscopic and X-ray characterization are described for both compounds. Products were prepared by reacting 4-bromobenzaldehyde (1) under Sonogashira coupling re
- Salinas-Ortega, Ismael,Ocayo, Fernanda,Santos, Juan C.,Trujillo, Alexander,Escobar, Carlos A.
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p. 361 - 367
(2016/09/14)
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- Porphyrin-based Pt/Pd-containing metallopolymers: Synthesis, characterization, optical property and potential application in bioimaging
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In this work, we report two metallopolymers (Pt-P and Pd-P) through coupling of PtII or PdII porphyrin with fluorene derivatives. The structure and photophysical properties of these two metallpolymers were fully characterized, which
- Bian, Wanli,Lian, Hong,Zhang, Yixia,Tai, Feifei,Wang, Hua,Dong, Qingchen,Yu, Baofeng,Wei, Xuehong,Zhao, Qiang
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- Method of rapidly preparing rhodamine dye with a plurality of active functional groups under mild condition
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The invention relates to a method of rapidly preparing a rhodamine dye with a plurality of active functional groups under the mild condition and belongs to the technical field of fine chemicals. The method is used for synthesizing rhodamine with specific
- -
-
Paragraph 0065; 0066; 0067
(2017/09/01)
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- Acetylenic Scaffolding with Subphthalocyanines
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A new boron subphthalocyanine (SubPc) derivative with a terminal alkyne substituent on the central boron atom was prepared by substitution of a triflate at the boron atom with but-3-yn-1-ol. This compound was shown to be a versatile building block for metal-catalyzed coupling reactions, such as modified Glaser-Hay, Cadiot-Chodkiewicz, and Sonogashira reactions as well as the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC). For example, metal-catalyzed reactions provided access to a SubPc dimer containing a butadiyne bridging unit, two different SubPc-fullerene dyads as well as two cross-conjugated SubPc-tetraethynylethene (TEE) scaffolds. These TEEs containing two silyl-protected alkyne units are potential building blocks for further acetylenic scaffolding. The work shows how the axial position is post-functionalized in steps not involving a substitution reaction at the central boron atom, which is otherwise often used as the terminal step in axial functionalization of SubPcs.
- Gotfredsen, Henrik,Jevric, Martyn,Kadziola, Anders,Nielsen, Mogens Brondsted
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supporting information
p. 17 - 21
(2016/01/20)
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- Synthesis, characterization and antimicrobial evaluation of novel (E)-N′-(4-(1-((3,4-dimethoxypyridin-2-yl)methyl)-1H-1,2,3-triazol-4-yl)benzylidene)benzohydrazide derivatives
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The synthesis of novel 1,2,3-triazole-hydrazone derivatives embedded with 3,4-dimethoxy pyridine ring nucleus is described. These derivatives were prepared utilizing, 2-(chloromethyl)-3,4-dimethoxypyridine 1, 4-ethynylbenzaldehye 5 and various benzohydrazides7a-7j. The structures of the newly synthesized 1,2,3-triazole-hydrazones 8a-j was established on the basis of the spectroscopic techniques like 1H NMR, mass and IR data. They were evaluated against a panel of bacterial and fungal pathogens such as Staphylococcus. pyogens, Staphylococcus. Aureus (Gram positive bacteria), Escherichia.coli, Pseudomonas. aeruginosa (Gram negative bacteria) and Aspergillus niger and Candida albicans (Fungal stains). Compounds 8b, 8c, 8d, 8e and 8f with R = 4-OH, 4-OMe, 4-SO2Me, 3,45,-OMe and 3-NO2 respectively showed moderate antibacterial activity while compounds 8b, 8d, 8i and 8j with R = 4-OH, 4-SO2Me, 3,5-dichloro and 2,5-difluoro substitution exhibited very good fungal activity.
- Saidugari, Swamy,Vadali, Lakshmana Rao,Vidya,Ram
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p. 2155 - 2161
(2016/10/24)
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- Synchronized Offset Stacking: A Concept for Growing Large-Domain and Highly Crystalline 2D Covalent Organic Frameworks
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Covalent organic frameworks (COFs), formed by reversible condensation of rigid organic building blocks, are crystalline and porous materials of great potential for catalysis and organic electronics. Particularly with a view of organic electronics, achievi
- Auras, Florian,Ascherl, Laura,Hakimioun, Amir H.,Margraf, Johannes T.,Hanusch, Fabian C.,Reuter, Stephan,Bessinger, Derya,D?blinger, Markus,Hettstedt, Christina,Karaghiosoff, Konstantin,Herbert, Simon,Knochel, Paul,Clark, Timothy,Bein, Thomas
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supporting information
p. 16703 - 16710
(2017/01/10)
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- An azine-linked hexaphenylbenzene based covalent organic framework
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In this communication, we report an azine linked covalent organic framework based on a six-fold symmetric hexphenylbenzene (HEX) monomer functionalized with aldehyde groups. HEX-COF 1 has an average pore size of 1 nm, a surface area in excess of 1200 msu
- Alahakoon, Sampath B.,Thompson, Christina M.,Nguyen, Amy X.,Occhialini, Gino,McCandless, Gregory T.,Smaldone, Ronald A.
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supporting information
p. 2843 - 2845
(2016/02/19)
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- A Bis-Manganese(II)–DOTA Complex for Pulsed Dipolar Spectroscopy
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High-spin gadolinium(III) and manganese(II) complexes have emerged as alternatives to standard nitroxide radical spin labels for measuring nanometric distances by using pulsed electron–electron double resonance (PELDOR or DEER) at high fields/frequencies.
- Demay-Drouhard, Paul,Bertrand, Hélène C.,Policar, Clotilde,Ching, H. Y. Vincent,Tabares, Leandro C.,Akhmetzyanov, Dmitry,Guillot, Régis
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p. 2066 - 2078
(2016/08/27)
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- Porphyrin-based metallopolymers: Synthesis, characterization and pyrolytic study for the generation of magnetic metal nanoparticles
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Metallopolymers with different metal centers, pendant groups and linkages exhibit diverse structures and properties, thus giving rise to versatile applications, e.g., as emissive and photovoltaic materials, optical limiters, materials for nano-electronics
- Dong, Qingchen,Qu, Wenshan,Liang, Wenqing,Tai, Feifei,Guo, Kunpeng,Leung, Chi-Wah,Lo, Yih Hsing,Wong, Wai-Yeung
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p. 5010 - 5018
(2016/06/15)
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- Preparation of Bodipy-ferrocene dyads and modulation of the singlet/triplet excited state of bodipy: Via electron transfer and triplet energy transfer
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Modulation of the singlet/triplet excited state of a fluorophore is becoming more important for molecular switches, molecular memory devices, chemical or biological sensors and controllable photodynamic therapy (PDT) etc. Boron-dipyrromethene (Bodipy)-ferrocene (Fc) dyads were prepared for reversible electrochemical switching of the singlet excited state (fluorescence), as well as the triplet excited states of Bodipy. The photophysical properties of the dyads were studied using steady-state UV-vis absorption spectroscopy, fluorescence, electrochemical characterization, time-resolved fluorescence and nanosecond transient absorption spectroscopies. The fluorescence of the Bodipy moieties in the dyads was quenched significantly, due to the photo-induced electron transfer (PET). This conclusion was supported by electrochemical characterization and calculation of the Gibbs free energy changes of PET. We demonstrated that the fluorescence of the Bodipy moiety can be reversibly switched ON and OFF by electrochemical oxidation of the Fc moiety (Fc/Fc+). Furthermore, we proved that the Fc moiety is efficient for quenching of the triplet excited states of Bodipy. Two quenching mechanisms, PET and triplet-triplet-energy transfer (TTET), are responsible for the intramolecular and intermolecular quenching of the triplet excited states of the diiodoBodipy unit.
- Wu, Xueyan,Wu, Wenting,Cui, Xiaoneng,Zhao, Jianzhang,Wu, Mingbo
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supporting information
p. 2843 - 2853
(2016/04/26)
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- Synthesis and Characterization of New Conjugated Fluorenyl-Porphyrin Dendrimers for Optics
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A new family of conjugated meso-tetraphenylporphyrin-based dendrimers with four (TPP1, TPP2), eight (TPP3, TPP4, TPP5) and up to sixteen (TPP6) fluorenyl groups has been synthesized and fully characterized. These tetraphenylporphyrin-cored dendrimers pres
- Yao, Dandan,Zhang, Xu,Mongin, Olivier,Paul, Frédéric,Paul-Roth, Christine O.
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p. 5583 - 5597
(2016/04/20)
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- Porphyrin two-dimension covalent organic framework conjugated polymer, and preparation method and application thereof
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The invention belongs to the fields of a metal ion battery and a super capacitor, and concretely relates to a porphyrin two-dimension covalent organic framework conjugated polymer, and a preparation method and an application thereof. A structural formula
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Paragraph 0029; 0054
(2016/10/07)
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- Synthesis of 3-substituted isoindolin-1-ones via a tandem desilylation, cross-coupling, hydroamidation sequence under aqueous phase-transfer conditions
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A simple and expedient method for the synthesis of 3-methylene-isoindolin-1-ones 4 under aqueous phase-transfer conditions has been developed. Starting from 2-iodobenzamides 1 and (silyl)alkynes, the products are obtained in high yields and short reaction times (30 min) with the use of inexpensive CuCl/PPh3 catalyst system in the presence of n-Bu4NBr (TBAB) as a phase-transfer agent. Terminal alkynes are conveniently "unmasked" upon in situ desilylation under the reaction conditions. Alkynes possessing heterocyclic moieties were also found as amenable substrates. Furthermore, a one-pot process starting from 2-iodobenzamides 1, aryl halides (bromides or iodides) and trimethylsilylacetylene (TMSA) as a convenient acetylene surrogate was also shown to be feasible under Pd/Cu catalysis.
- Munoz, Socrates B.,Aloia, Alexandra N.,Moore, Alexander K.,Papp, Attila,Mathew, Thomas,Fustero, Santos,Olah, George A.,Surya Prakash
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supporting information
p. 85 - 92
(2015/12/30)
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- Synthesis of new styrylquinoline cellular dyes, fluorescent properties, cellular localization and cytotoxic behavior
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New styrylquinoline derivatives with their photophysical constants are described. The synthesis was achieved via Sonogashira coupling using the newly developed heterogeneous nano-Pd/Cu catalyst system, which provides an efficient synthesis of high purity
- Rams-Baron, Marzena,Dulski, Mateusz,Mrozek-Wilczkiewicz, Anna,Korzec, Mateusz,Cieslik, Wioleta,Spaczyńska, Ewelina,Bartczak, Piotr,Ratuszna, Alicja,Polanski, Jaroslaw,Musiol, Robert
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- A double bond-conjugated dimethylnitrobenzene-type photolabile nitric oxide donor with improved two-photon cross section
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Abstract Photocontrollable NO donors enable precise spatiotemporal release of NO under physiological conditions. We designed and synthesized a novel dimethylnitrobenzene-type NO donor, Flu-DNB-DB, which contains a carbon-carbon double bond in place of the
- Ieda, Naoya,Hishikawa, Kazuhiro,Eto, Kei,Kitamura, Kai,Kawaguchi, Mitsuyasu,Suzuki, Takayoshi,Fukuhara, Kiyoshi,Miyata, Naoki,Furuta, Toshiaki,Nabekura, Junichi,Nakagawa, Hidehiko
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supporting information
p. 3172 - 3175
(2015/07/08)
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- Palladium end-capped polyynes via oxidative addition of 1-haloalkynes to Pd(PPh3)4
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Reported here is the use of 1-haloacetylenes and 1-halopolyynes as synthons for the preparation of new palladium(II) end-capped polyynes. The 1-haloalkynes were obtained in a series of transformations from para-substituted bromoarenes that included Sonogashira coupling followed by halogenation and chain elongation via Cadiot-Chodkiewicz protocol. The key step for the synthesis of metal complexes was oxidative addition of 1-haloalkynes to Pd(PPh3)4, which allowed obtaining a series of metal compounds 1-5-CnX with carbon chains up to hexatriyne in 75-100% yield. All the compounds were characterized by NMR and HRMS or elemental analysis. The 13C spectra of the 1-haloalkynes showed interesting, although expected, shifts of the carbon chain atoms close to the halogen termini. X-ray crystal structures were obtained for three polyynes-two butadiynes (2-C4[Pd]Br and 3-C4[Pd]Br) and one hexatriyne (1-C6[Pd]Br)-and the latter is the first reported X-ray crystal structure of palladium end-capped hexatriyne.
- Gulia, Nurbey,Pigulski, Bartlomiej,Szafert, Slawomir
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supporting information
p. 673 - 682
(2015/05/12)
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- Systematic variation of cyanobuta-1,3-dienes and expanded tetracyanoquinodimethane analogues as electron acceptors in photoactive, rigid porphyrin conjugates
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We report on a homologous series of nine electron donor-acceptor systems featuring push-pull chromophores as electron acceptors, which are accessible by a cycloaddition-retroelectrocyclization (CA-RE) reaction. The conjugates comprise a ZnII porphyrin as electron donor, which is connected through either a rigid phenylene-ethynylene-phenylene (PEP)-bicyclo[2.2.2]octane or a PEP-trans-decahydroquinoline spacer to different anilino-substituted multicyanobutadienes or extended tetracyanoquinodimethane analogues with first reduction potentials ranging from-1.78 to-0.58 V vs. Fc+/Fc. Characterization of the conjugates includes X-ray crystallography, electrochemistry, DFT calculations, and fluorescence spectroscopy. The extent of ZnII porphyrin fluorescence quenching correlates with the strength of the electron acceptor. Overall, we demonstrate the synthetic feasibility of rationally modulating the acceptor strength by means of the CA-RE reaction in geometrically well-defined electron donor-acceptor conjugates.
- Urner, Lorenz M.,Sekita, Michael,Trapp, Nils,Schweizer, W. Bernd,W?rle, Michael,Gisselbrecht, Jean-Paul,Boudon, Corinne,Guldi, Dirk M.,Diederich, Franois
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supporting information
p. 91 - 108
(2015/02/19)
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