275386-60-2

Usage

Uses

Used in Organic Synthesis:
4-(TRIMETHYLSILYLETHYNYL)BENZYL ALCOHOL is used as a building block for introducing the ethynyl group into larger molecules, facilitating the synthesis of complex organic compounds.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, 4-(TRIMETHYLSILYLETHYNYL)BENZYL ALCOHOL is used as a key intermediate for the development of new drugs, contributing to the creation of novel therapeutic agents.
Used in Agrochemical Synthesis:
4-(TRIMETHYLSILYLETHYNYL)BENZYL ALCOHOL is utilized as a precursor in the synthesis of agrochemicals, aiding in the development of new pesticides and other agricultural chemicals.
Used in Fine Chemicals Synthesis:
In the production of fine chemicals, 4-(TRIMETHYLSILYLETHYNYL)BENZYL ALCOHOL is used as a versatile intermediate, enabling the synthesis of high-quality specialty chemicals for various applications.
Used in Material Science:
4-(TRIMETHYLSILYLETHYNYL)BENZYL ALCOHOL is employed as a reagent in material science for the development of new materials, playing a crucial role in advancing the field of material chemistry.
Used in Organic Reactions:
In the realm of organic reactions, 4-(TRIMETHYLSILYLETHYNYL)BENZYL ALCOHOL is used as a reactant in processes such as Suzuki-Miyaura coupling and Sonogashira coupling, which are essential for the formation of carbon-carbon bonds in organic molecules.

InChI:InChI=1/C12H16OSi/c1-14(2,3)9-8-11-4-6-12(10-13)7-5-11/h4-7,13H,10H2,1-3H3

Upstream product

• 150969-54-3 ethyl 4-(trimethylsilylethynyl)benzoate 
• 75867-41-3 4-trimethylsilanylethynyl-benzoic acid methyl ester 
• 873-75-6 4-bromobenzenemethanol 
• 1066-54-2 trimethylsilylacetylene 
• 77123-58-1 2-[2-(trimethylsilyl)ethynyl]benzaldehyde 
• 77123-57-0 4-[(trimethylsilyl)ethynyl]bezaldehyde 
• 51934-41-9 4-iodobenzoic acid ethyl ester 
• 1041297-60-2 acetic acid 4-trimetylsilanylethynyl-benzyl ester 
• 1122-91-4 4-bromo-benzaldehyde 
• 18282-51-4 4-iodo-benzyl alcohol 
• 109-89-7 diethylamine 
• 619-42-1 4-methoxycarbonylphenyl bromide 

Downstream Products

• 870719-33-8 4-ethynylbenzyl 3,5-bis[3',4'-di(octan-1-yloxy)benzyloxy]benzoate 
• 870719-39-4 4-ethynylbenzyl 3,5-bis[3',4'-di((S)-3,7-dimethyloctan-1-yloxy)benzyloxy]benzoate 
• 870719-35-0 4-ethynylbenzyl 3,5-bis[3',4'-di(decan-1-yloxy)benzyloxy]benzoate 
• 474297-38-6 4-ethynylbenzyl 3,5-bis(3',4'-bis(dodecan-1-yloxy)benzyloxy)benzoate 
• 870719-59-8 4-ethynylbenzyl 3,5-bis[3',4'-di(tetradecan-1-yloxy)benzyloxy]benzoate 
• 1360803-52-6 3-(4-(prop-1-yn-1-yl)phenyl)propionic acid ethyl ester 
• 1360803-56-0 methyl 2-(N-(4-(prop-1-yn-1-yl)benzyl)-3-(4-(prop-1-yn-1-yl)phenyl)propanamido)acetate-d₅ 
• 1360803-57-1 2-(N-(4-(prop-1-yn-1-yl)benzyl)-3-(4-(prop-1-yn-1-yl)phenyl)propanamido)acetic acid-d5 
• 1093190-17-0 tert-butyl[(4-ethynylphenyl)methoxy]dimethylsilane 
• 82657-70-3 4-n-propylbenzyl alcohol 
• 1360803-33-3 1-(iodomethyl)-4-propylbenzene 
• 1360803-34-4 methyl 2-((4-propylbenzyl)amino)acetate 
• 1360803-48-0 1-(iodomethyl)-4-(prop-1-yn-1-yl)benzene 
• 1360803-46-8 (4-(prop-1-yn-1-yl) phenyl)methanol 

Relevant academic research and scientific papers

Thermoresponsive helical poly(phenylacetylene)s

Poly(phenylacetylene) (PPA) bearing dendritic oligo(ethylene glycol) (OEG) as pendants was synthesized, and its thermoresponsiveness and helical conformation were investigated. Despite the steric hindrance of the bulky pendants in the homopolymer PPA-OEG,

Electrochemical Single-Molecule Transistors with Optimized Gate Coupling

Electrochemical gating at the single molecule level of viologen molecular bridges in ionic liquids is examined. Contrary to previous data recorded in aqueous electrolytes, a clear and sharp peak in the single molecule conductance versus electrochemical potential data is obtained in ionic liquids. These data are rationalized in terms of a two-step electrochemical model for charge transport across the redox bridge. In this model the gate coupling in the ionic liquid is found to be fully effective with a modeled gate coupling parameter, ξ, of unity. This compares to a much lower gate coupling parameter of 0.2 for the equivalent aqueous gating system. This study shows that ionic liquids are far more effective media for gating the conductance of single molecules than either solid-state three-terminal platforms created using nanolithography, or aqueous media.

Iron-Catalyzed Tertiary Alkylation of Terminal Alkynes with 1,3-Diesters via a Functionalized Alkyl Radical

Direct oxidative C(sp)?H/C(sp3)?H cross-coupling offers an ideal and environmentally benign protocol for C(sp)?C(sp3) bond formations. As such, reactivity and site-selectivity with respect to C(sp3)?H bond cleavage have remained a persistent challenge. Herein is reported a simple method for iron-catalyzed/silver-mediated tertiary alkylation of terminal alkynes with readily available and versatile 1,3-dicarbonyl compounds. The reaction is suitable for an array of substrates and proceeds in a highly selective manner even employing alkanes containing other tertiary, benzylic, and C(sp3)?H bonds alpha to heteroatoms. Elaboration of the products enables the synthesis of a series of versatile building blocks. Control experiments implicate the in situ generation of a tertiary carbon-centered radical species.

Synthesis of siRNAs incorporated with cationic peptides R8G7 and R8A7 and the effect of the modifications on siRNA properties

Small interfering RNA (siRNA) can be used as an innovative next-generation drug. However, there are several challenges in the therapeutic application of siRNAs, including their low cell membrane permeability. In this study, we designed and synthesized siR

Regio- A nd chemoselective deprotection of primary acetates by zirconium hydrides

A combination of DIBAL-H and Cp2ZrCl2 is shown to promote the regioselective cleavage of primary acetates on a broad scope of substrates, ranging from carbohydrates to terpene derivatives, with a high tolerance toward protecting groups and numerous functionalities found in natural products and bioactive compounds. Apart from providing highly valuable building blocks in only two steps from biosourced raw materials, this selective de-O-acetylation should also be strongly helpful to solve selectivity issues in organic synthesis.

Triplet–Triplet Annihilation Upconversion for Photocatalytic Hydrogen Evolution

The solar generation of hydrogen by water splitting provides a promising path for renewable hydrogen production and solar energy storage. Upconversion of low-energy photons into high-energy photons constitutes a promising strategy to enhance the light harvesting efficiency of artificial hydrogen production systems. In the present study, upconversion micelles are integrated with Cd0.5Zn0.5S to construct solar energy conversion systems. The upconversion micelle is employed to upconvert red photons to cyan photons. Cd0.5Zn0.5S is sensitized by upconverted cyan light to produce hydrogen, but not by incident red light without triplet–triplet annihilation upconversion (TTA-UC). The performance of the upconversion photocatalytic system was dramatically affected by the concentration of Cd0.5Zn0.5S and the irradiation intensity. This novel system was able to produce about 2.3 μL hydrogen after 5 h of red light (629 nm) irradiation (2.4 mW cm?2). The present study provides a candidate for applications using low-energy photons for solar hydrogen generation.

Synthesis and biological evaluation of PF-543 derivative

PF-543 has been known as a substance that strongly inhibits SK1. However, it also exhibits antineoplastic activity that is lower than other inhibitors of SK1. In this study, we compared PF-543 and synthesized a newly designed derivative of PF-543 (compoun

APOPTOSIS INHIBITORS

The invention provides compounds that are inhibitors or covalent modifiers of succinate dehydrogenase subunit B (SDHB) and/or inhibitors of apoptosis, and pharmaceutically acceptable salts, hydrides and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition.

INDOLINONE DERIVATIVES AS INHIBITORS OF MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE

The present disclosure relates to indolinone compounds, compositions, and methods for the inhibition of maternal embryonic leucine zipper kinase (MELK). The present disclosure further relates to indolinone compounds, compositions, and methods for the treatment or prevention of a cancer (for example, triple negative breast cancer).

Twisting of Alkynes towards a Carbon Double Helix

The carbon allotrope exhibiting only one-dimensional sp-hybridized carbon atoms is called carbyne. However, its existence is very controversial. Studies on model compounds for carbyne revealed that many oligoalkynes show not a straight, but a bent structu