- Preparation method and application of 4-hydroxy-2-oxo-1-pyrrolidine acetic acid
-
The invention provides a preparation method of 4-hydroxy-2-oxo-1-pyrrolidine acetic acid, and the preparation method comprises the following steps: mixing oxiracetam and a lithium compound to react, so as to obtain the 4-hydroxy-2-oxo-1-pyrrolidine acetic acid. The preparation method provided by the invention is simple to operate, high in yield, high in purity and simple and convenient in post-treatment.
- -
-
Paragraph 0034-0057
(2021/05/05)
-
- Process for the production of 4-hydroxy-2-oxopyrrolidin-1-yl-acetamide
-
Process for the production of 4-hydroxy-2-oxoyrrolidin-1-yl-acetamide, a cerebrally active pharmaceutical agent. A 4-halo-3-alkoxy-butenoic acid ester is reacted with glycine to new intermediate products of the formula: STR1 There is further by acid hydrolysis of the alkoxy group, subsequent hydrogenation, esterification of the carboxyl function and finally conversion to the end product by reaction with ammonia.
- -
-
-
- Cyclic GABA-GABOB analogues. IV. Activity on learning and memory.
-
A number of N-substituted 4-hydroxy-, 4-acyloxy- and 4-alkoxy-2-pyrrolidinones were examined by a screening method predictive of their activity on cognitive processes. The 1-aminocarbonylmethyl-substituted compounds showed a favorable effect on learning and memory, and among them the most active was the 4-hydroxy derivative, oxiracetam, which had a potency considerably higher than piracetam, used for comparison purposes.
- Banfi,Fonio,Allievi,Pinza,Dorigotti
-
-