77191-37-8

Usage

Uses

Used in Pharmaceutical Industry:
4-Hydroxy-2-oxo-1-pyrrolidineacetic acid is used as a nootropic agent for enhancing cognitive functions and memory. Its psychostimulant activity makes it a promising candidate for the development of drugs aimed at improving brain performance and treating cognitive disorders.
Used in Cognitive Enhancement:
4-Hydroxy-2-oxo-1-pyrrolidineacetic acid is used as a cognitive enhancer to improve memory, learning, and focus. Its psychostimulant properties may help in increasing alertness and attention, making it a potential candidate for the treatment of attention deficit disorders and other cognitive impairments.
Used in Research and Development:
In the field of neuroscience and pharmaceutical research, 4-Hydroxy-2-oxo-1-pyrrolidineacetic acid serves as a valuable compound for studying the mechanisms underlying cognitive enhancement and the development of novel therapeutic strategies for neurological and psychiatric conditions.

InChI:InChI=1/C6H9NO4/c8-4-1-5(9)7(2-4)3-6(10)11/h4,8H,1-3H2,(H,10,11)

Upstream product

• 62613-80-3 1-ethoxycarbonylmethylpyrrolidine-2,4-dione 
• 62613-81-4 ethyl (4-hydroxy-2-oxopyrrolidin-1-yl)acetate 
• 68252-28-8 oxiracetam 
• 142274-08-6 (4-ethoxy-1,5-dihydro-2-oxo-2H-pyrrol-1-yl)acetic acid 
• 114012-62-3 (1,5-dihydro-4-methoxy-2-oxo-2H-pyrrol-1-yl)acetamide 
• 142274-11-1 2,4-dioxopyrrolidin-1-yl-acetic acid 
• 142352-10-1 (2,4-dioxopyrrolidin-1-yl)acetamide hydrochloride 
• 110104-61-5 ethyl (2,5-dihydro-4-methoxy-2-oxo-1H-pyrrol-1-yl)acetate 

Downstream Products

• 99437-11-3 ((S)-4-hydroxy-2-oxopyrrolidin-1-yl)acetic acid 
• 62613-81-4 ethyl (4-hydroxy-2-oxopyrrolidin-1-yl)acetate 

Relevant academic research and scientific papers

Preparation method and application of 4-hydroxy-2-oxo-1-pyrrolidine acetic acid

The invention provides a preparation method of 4-hydroxy-2-oxo-1-pyrrolidine acetic acid, and the preparation method comprises the following steps: mixing oxiracetam and a lithium compound to react, so as to obtain the 4-hydroxy-2-oxo-1-pyrrolidine acetic acid. The preparation method provided by the invention is simple to operate, high in yield, high in purity and simple and convenient in post-treatment.

Process for the production of 4-hydroxy-2-oxopyrrolidin-1-yl-acetamide

Process for the production of 4-hydroxy-2-oxoyrrolidin-1-yl-acetamide, a cerebrally active pharmaceutical agent. A 4-halo-3-alkoxy-butenoic acid ester is reacted with glycine to new intermediate products of the formula: STR1 There is further by acid hydrolysis of the alkoxy group, subsequent hydrogenation, esterification of the carboxyl function and finally conversion to the end product by reaction with ammonia.

Cyclic GABA-GABOB analogues. IV. Activity on learning and memory.

A number of N-substituted 4-hydroxy-, 4-acyloxy- and 4-alkoxy-2-pyrrolidinones were examined by a screening method predictive of their activity on cognitive processes. The 1-aminocarbonylmethyl-substituted compounds showed a favorable effect on learning and memory, and among them the most active was the 4-hydroxy derivative, oxiracetam, which had a potency considerably higher than piracetam, used for comparison purposes.