- Tetrahydrocoptisine derivative and applications thereof
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The present invention relates to a compound as shown in a formula (VII), a preparation method and applications thereof in medicines. In particular, the present invention relates to a derivative of the compound as shown in the formula (VII), a preparation method, and the applications of the derivative used as a therapeutic agent in prevention and treatment of hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, hepatic steatosis, II-type diabetes, hyperglycemia, obesity or insulin resistance syndrome and metabolic syndrome. The compound disclosed by the present invention can also reduce total cholesterol, LDL-cholesterol and triglyceride, and increases expression of a liver LDL receptor and decreases expression of PCSK9.
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Paragraph 0422; 0423; 0424
(2016/10/08)
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- Synthesis of aryl sulfonamides via palladium-catalyzed chlorosulfonylation of arylboronic acids
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A palladium-catalyzed method for the preparation of sulfonamides is described. The process exhibits significant functional group tolerance and allows for the preparation of a number of arylsulfonyl chlorides and sulfonamides under mild conditions.
- Debergh, J. Robb,Niljianskul, Nootaree,Buchwald, Stephen L.
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supporting information
p. 10638 - 10641
(2013/08/23)
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- From homogeneous to heterogeneous catalysis of the three-component coupling of oxysulfonyl azides, alkynes, and amines
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A reliable procedure for the synthesis of oxysulfonyl azides has been developed and applied to the three-component coupling reactions of azides, alkynes, and amines catalyzed homogeneously by CuI, which led to the formation of N-oxysulfonyl amidines with
- Yang, Tao,Cui, Hao,Zhang, Changhe,Zhang, Li,Su, Cheng-Yong
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p. 3131 - 3138
(2013/10/21)
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