- On the Nature of 'Haematoporphyrin Derivative'
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The components of haematoporphyrin derivative ( a preparation used as a photosensitiser in clinical applications, and made by treating haematoporphyrin with sulphuric acid-acetic acid) have been separated by preparative h.p.l.c. and identified by comparison with authentic porphyrincarboxylic acids.The composition of the mixture is somewhat variable but the main components are O,O'-diacetylhaematoporphyrin (6) and O-acetylhaematoporphyrin (2)/(3) with smaller amounts of the 8(3)-(1-acetoxyethyl)-3(8)-vinyldeuteroporphyrin isomers (7) and (8) and the corresponding alcohols (4) and (5).
- Bonnett, Raymond,Ridge, Richard J.,Scourides, Panayiotis A.,Berenbaum, Morris C.
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p. 3135 - 3140
(2007/10/02)
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- Haematoporphyrin Derivative
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Components of 'haematoporphyrin derivative,' a photosensitiser employed in clinical studies, have been separated as the free acids by reverse-phase high pressure liquid chromatography, and identified, the major components being O,O'-diacetylhaematoporphyrin and O-acetylhaematoporphyrin.
- Bonnett, Raymond,Ridge, Richard J.,Scourides, Panayiotis A.,Berenbaum, Morris C.
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p. 1198 - 1199
(2007/10/02)
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