Synthesis of isoquinoline alkaloid, (±)-salsolidine, using thiazolino[2,3-a]isoquinolinone S-oxide as intermediate
Thiazolino[2,3-a]isoquinolinones have been oxidized to the corresponding S-oxides and their 10b-methyl derivatives desulfurized with Raney nickel to give (±) N-acyl salsolidine. Base-catalyzed hydrolysis of the N-acetyl derivative afforded (±)-salsolidine. C-Methylation reactions of the title heterocyclic system have been investigated throughly. Stereochemistry of the synthesized compounds has been established.
Rozwadowska,Sulima
p. 1847 - 1852
(2007/10/03)
INFLUENCE OF TYPE OF CHEMICAL BOND BETWEEN MACROMOLECULE AND MEDICINAL PREPARATION ON THE PROPERTIES OF PHYSIOLOGICALLY ACTIVE COMPOUNDS
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Nadzhimutdinov, Sh.,Uzakov, I.,Turaev, A. S.,Usmanov, Kh. U.,Kamilov, I. K.
p. 112 - 116
(2007/10/02)
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