773122-52-4

Basic information

• Product Name: 3-AMINO-3-(2,5-DIFLUORO-PHENYL)-PROPIONIC ACID
• Synonyms: RARECHEM AL BL 0211;3-AMINO-3-(2,5-DIFLUORO-PHENYL)-PROPIONIC ACID
• CAS NO: 773122-52-4
• Molecular Formula: C₉H₉F₂NO₂
• Molecular Weight: 201.17
• EINECS: 604-604-1
• Mol File: 773122-52-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-AMINO-3-(2,5-DIFLUORO-PHENYL)-PROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-3-(2,5-DIFLUORO-PHENYL)-PROPIONIC ACID(773122-52-4)
• EPA Substance Registry System: 3-AMINO-3-(2,5-DIFLUORO-PHENYL)-PROPIONIC ACID(773122-52-4)

Safety Data

• Hazardous Substances Data: 773122-52-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-AMINO-3-(2,5-DIFLUORO-PHENYL)-PROPIONIC ACID is used as an intermediate in the synthesis of non-steroidal anti-inflammatory drugs (NSAIDs) and other pharmaceuticals. Its unique structure and reactivity make it a key component in the development of new medications.
Used in Agrochemical Industry:
3-AMINO-3-(2,5-DIFLUORO-PHENYL)-PROPIONIC ACID is used as a building block in the creation of agrochemicals, contributing to the development of effective and innovative products for agricultural applications.
Used in Organic Chemistry:
3-AMINO-3-(2,5-DIFLUORO-PHENYL)-PROPIONIC ACID is utilized in organic chemistry for its unique chemical properties, enabling the synthesis of a variety of organic compounds with potential applications in various fields.
Used in Materials Science:
3-AMINO-3-(2,5-DIFLUORO-PHENYL)-PROPIONIC ACID is employed in materials science to explore its potential in creating new materials with specific properties, such as enhanced reactivity or stability.

Upstream product

• 141-82-2 malonic acid 
• 2646-90-4 2,5-difluorobenzaldehyde 

Downstream Products

• 1228571-37-6 (S)-3-amino-3-(2',5'-difluorophenyl)propanoic acid 
• 1228561-26-9 (R)-3-amino-3-(2,5-difluorophenyl)propionic acid 
• 1292457-09-0 3-amino-3-(2,5-difluorophenyl)propionic acid ethyl ester 
• 1096828-54-4 3-amino-3-(2,5-difluorophenyl)propionic acid ethyl ester 

Relevant articles and documents

1-PHENYLPYRROLIDIN-2-ONE DERIVATIVES AS PERK INHIBITORS

The invention is directed to substituted pyrrolidinone and imidazolidinone derivatives. Specifically, the invention is directed to compounds according to Formula I: (I) wherein R1, R2, R3, R4, R5, R6, R7, X and Y are as defined herein. The compounds of the invention are inhibitors of PERK and can be useful in the treatment of cancer, pre-cancerous syndromes and diseases/injuries associated with activated unfolded protein response pathways, such as Alzheimer's disease, neuropathic pain, spinal cord injury, traumatic brain injury, ischemic stroke, stroke, Parkinson's disease, diabetes, metabolic syndrome, metabolic disorders, Huntington's disease, Creutzfeldt- Jakob Disease, fatal familial insomnia, Gerstmann-Str?ussler-Scheinker syndrome, and related prion diseases, amyotrophic lateral sclerosis, progressive supranuclear palsy, myocardial infarction, cardiovascular disease, inflammation, organ fibrosis, chronic and acute diseases of the liver, fatty liver disease, liver steatosis, liver fibrosis, chronic and acute diseases of the lung, lung fibrosis, chronic and acute diseases of the kidney, kidney fibrosis, chronic traumatic encephalopathy (CTE), neurodegeneration, dementias, frontotemporal dementias, tauopathies, Pick's disease, Neimann-Pick's disease, amyloidosis, cognitive impairment, atherosclerosis, ocular diseases, arrhythmias, in organ transplantation and in the transportation of organs for transplantation. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting PERK activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

OXATHIAZINE DERIVATIVES WHICH ARE SUBSTITUTED WITH BENZYL OR HETEROMETHYLENE GROUPS, METHOD FOR PRODUCING THEM, THEIR USE AS MEDICINE AND DRUG CONTAINING SAID DERIVATIVES AND THE USE THEREOF

The invention relates to the compounds of formula (I) and to the physiologically acceptable salts thereof. Said compounds are suitable e.g. for the treatment of hyperglycemia.

NOVEL SUBSTITUTED PHENYL-OXATHIAZINE DERIVATIVES, METHOD FOR PRODUCING THEM, DRUGS CONTAINING SAID COMPOUNDS AND THE USE THEREOF

The invention relates to the compounds of formula (I) and to the physiologically acceptable salts thereof. Said compounds are suitable e.g. for the treatment of hyperglycemia.