2646-90-4

Basic information

• Product Name: 2,5-Difluorobenzaldehyde
• Synonyms: TIMTEC-BB SBB006570;2,5-DIFLUOROBENZALDEHYDE;2,5-Difluorobenzaldehyde 98%;2,5-Difluorobenzaldehyde98%;2,5-DIFLUOROBENZALDEHYDE 99+%;2,5-Difluorobenzalde;2,5-fluorobenzaldehyde;Difluorobenzaldehyde
• CAS NO: 2646-90-4
• Molecular Formula: C₇H₄F₂O
• Molecular Weight: 142.1
• EINECS: -0
• Product Categories: Fluorin-contained benzaldehyde series;Aromatic Aldehydes & Derivatives (substituted);Benzaldehyde;Fluorobenzene;Miscellaneous;Adehydes, Acetals & Ketones;Fluorine Compounds;Fluorobenzaldehyde Series;Aldehydes;C7;Carbonyl Compounds;Benzaldehyde series;Fluorine series
• Mol File: 2646-90-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 67-69 °C
• Boiling Point: 67-69 °C17 mm Hg(lit.)
• Flash Point: 138 °F
• Appearance: Clear colorless to yellow/Liquid
• Density: 1.308 g/mL at 25 °C(lit.)
• Vapor Pressure: 1.16mmHg at 25°C
• Refractive Index: n20/D 1.498(lit.)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive: Air Sensitive
• BRN: 2573664
• CAS DataBase Reference: 2,5-Difluorobenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Difluorobenzaldehyde(2646-90-4)
• EPA Substance Registry System: 2,5-Difluorobenzaldehyde(2646-90-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39-36/37
• RIDADR: UN 1989 3/PG 3
• WGK Germany: 3
• HazardClass: 3.2
• PackingGroup: III
• Hazardous Substances Data: 2646-90-4(Hazardous Substances Data)

Usage

Chemical Properties

clear light yellow liquid

Uses

2,5-Difluorobenzaldehyde was used in the synthesis of fluorinated analog by Henry condensation with nitroethane.

General Description

The emission and absorption spectra of 2,5-difluorobenzaldehyde were studied.

InChI:InChI=1/C7H4F2O/c8-6-1-2-7(9)5(3-6)4-10/h1-4H

Upstream product

• 540-36-3 para-difluorobenzene 
• 68-12-2 N,N-dimethyl-formamide 
• 1360804-81-4 acetoxy-2,5-difluorophenylacetonitrile 
• 93-61-8 N-methyl-N-phenylformamide 
• 452-67-5 1,4-difluoro-2-methylbenzene 

Downstream Products

• 844476-74-0 (2S,4R)-2-[(2,5-difluorobenzylamino)methyl]-4-tritylsulfanylpyrrolidine-1-carboxylic acid isopropyl ester 
• 391889-57-9 (2S,4R)-(2,5-difluorobenzyl)-[1-(5-propylpyrimidin-2-yl)-4-tritylsulfanylpyrrolidin-2-ylmethyl]amine 
• 247092-13-3 2,5-difluorobenzaldehyde oxime 
• 908292-39-7 1-(2,4-difluorophenyl)pentane-1,4-dione 
• 680230-00-6 methyl (2Z)-2-{[(benzyloxy)carbonyl]amino}-3-(2,5-difluorophenyl)prop-2-enoate 
• 717895-15-3 (4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-[3-(2,5-difluoro-benzylamino)-phenyl]-methanone 
• 699016-26-7 tert-butyl [(2R)-2-(3-chlorophenyl)-2-hydroxyethyl][(1R)-2-[4-[(4-fluoro-2-formylphenyl)thio]-phenyl]-1-methylethyl]carbamate 
• 699016-28-9 2,2,2-trifluoro-N-[(1R)-2-[4-[(4-fluoro-2-formylphenyl)thio]phenyl]-1-methylethyl]acetamide 
• 198633-77-1 3,6-difluoro-2-methylbenzonitrile 
• 1028090-05-2 5-fluoro-2-pyrrolidin-1-ylbenzaldehyde 
• 883535-68-0 5-fluoro-2-morpholin-4-ylbenzaldehyde 
• 923601-71-2 2-tert-butoxycarbonylamino-3-(2,5-difluorophenyl)-acrylic acid methyl ester 
• 1252643-91-6 C₁₀H₉FOS 
• 1354381-94-4 N-(4-nitrophenyl)-3-amino-3-(2,5-difluorophenyl)-1-phenylprop-1-yne 

Relevant articles and documents

Synthesis method for improving yield of 2, 5-difluorobenzaldehyde by adopting negative ion stabilizer

The invention provides a synthesis method for increasing the yield of 2, 5-difluorobenzaldehyde by adopting a negative ion stabilizer, which comprises the following steps: S1, dissolving a raw material p-difluorobenzene in a solvent, adding the negative ion stabilizer into the mixed solution, and controlling the temperature at -70 to -40 DEG C, S2, adding n-butyllithium into the reaction solutionobtained in the step S1, carrying out heat preservation and stirring for 30 minutes, and controlling the temperature to be -70 to -40 DEG C, S3, dropwise adding N, N-dimethylformamide into the reaction solution of the element in S2, and determining the HPLC content of the raw materials in the reaction solution, and S4, carrying out aftertreatment quenching, extraction, acid regulation, concentration and rectification on the reaction solution obtained in the step S3 to obtain the product.Wherein the negative ion stabilizer in S1 is any one of pentamethyldiethylenetriamine, tetramethylethylenediamine and hexamethylphosphoramide, and the negative ion stabilizer is 0.7-1.4 molar equivalents of p-difluorobenzene. The complexing agent and the organic lithium reagent are subjected to complexing reaction, so that the stability of the lithium reagent is improved, the reaction yield is greatly improved, and industrial production is easy to realize.

Ethanobenzazepines

Novel ethanobenzazepines, processes for the preparation thereof, and a method of alleviating pain utilizing compounds or compositions thereof are disclosed.