- Transition Metal-Diene Complexes in Organic Synthesis - 13. Highly Chemo- and Stereoselective Oxidations of Tricarbonyliron-Cyclohexadiene Complexes: Synthesis of 4-Deoxycarbazomycin B
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Chemo- and stereoselectivity in oxidations of tricarbonyl4-cyclohexa-1,3-diene>iron complexes is achieved by the choice of the oxidizing reagent.This procedure provides iron-complexed 4a,9a-dihydro-9H-carbazoles, 4b,8a-dihydrocarbazol-
- Knoelker, Hans-Joachim,Bauermeister, Michael,Pannek, Joern-Bernd,Blaeser, Dieter,Boese, Roland
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- BICYCLIC HETEROARYL SUBSTITUTED COMPOUNDS
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Disclosed are compounds of Formula (I) to (VIII): (I) (II) (III) (IV) (V) (VI) (VII) (VIII); or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof, wherein R3 is a bicyclic heteroaryl group substituted with zero to 3 R3a; and R1, R2, R3a, R4, and n are defined herein. Also disclosed are methods of using such compounds as PAR4 inhibitors, and pharmaceutical compositions comprising such compounds. These compounds are useful in inhibiting or preventing platelet aggregation, and are useful for the treatment of a thromboembolic disorder or the primary prophylaxis of a thromboembolic disorder.
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Page/Page column 184; 185
(2018/03/25)
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- A normal pressure catalytic synthesis of aniline compounds and the use of catalyst (by machine translation)
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A normal pressure catalytic synthesis of aniline compounds is the nitrobenzene compound and solvent after mixing, adding catalyst to form suspension, then transfer to the with a quartz window in the high-pressure reactor, reactor for sealing and hydrogen purge after washing, maintaining a hydrogen under normal pressure conditions, under stirring condition, heating the reaction system to10-50oC, in strength is0.01-5W/cm2under the illumination of the reaction, the reaction time is 5 - 180min. This invention has mild condition, environmental protection, low cost, simple operation, reaction period is short, high product yield, selectivity is good. (by machine translation)
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Paragraph 0079-0082
(2017/04/14)
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- A direct palladium-catalyzed route to selectively substituted carbazoles through sequential C-C and C-N bond formation: Synthesis of carbazomycin A
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The present paper offers a synthetically simple one-pot procedure for the catalytic preparation of the biologically interesting class of carbazoles. The new procedure is based on the combined catalysis of palladium and norbornene starting from o-substituted iodoarenes and N-sulfonylated or N-acetylated o-bromoanilines. A well-known member of this class, carbazomycin A, has been successfully prepared.
- Della Ca', Nicola,Sassi, Giovanni,Catellani, Marta
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supporting information; experimental part
p. 2179 - 2182
(2009/10/02)
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- Spiro derivatives as lipoxygenase inhibitors
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The present invention is concerned with certain novel spiro substituted heterocylic ring derivatives. These compounds may be useful in the manufacture of pharmaceutical compositions for treating disorders mediated by lipoxygenases. They may also be useful
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Page/Page column 95
(2008/06/13)
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- DIHYDROBENZOFURAN DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS
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A compound represented by the formula (I): or a salt thereof exhibits excellent inhibitory activity of lipid peroxidation and is useful as an agent for inhibiting lipoperoxide production, wherein A ring denotes a non-aromatic 5- to 7-membered nitrogen-con
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